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Director Clinical Operations Jobs (NOW HIRING)

Clinovo

Dir, Clinical Operations

Cambridge, MA · On-site

... Clinical Operations leader who thrives in lean, fast-moving environments and is energized by the opportunity to help build infrastructure, teams (direct and/or external relationships), and ...

Doist

Director, Clinical Operations

Boston, MA · On-site

$215 - $240/hr

Role Overview The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders ...

Doist

Director, Clinical Operations

Seattle, WA · On-site

$215 - $240/hr

Role Overview The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders ...

Doist

Director, Clinical Operations

San Francisco, CA · On-site

$215 - $240/hr

Role Overview The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders ...

Alira Health

Summary The Senior Director, Clinical Operations, is a key member of the Executive Leadership Team responsible for the strategic and operational leadership of the Company's clinical development ...

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Director Clinical Operations information

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$146K

$282.5K

How much do director clinical operations jobs pay per year?

As of Aug 9, 2026, the average yearly pay for director clinical operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What does a director of clinical operations do?

A director of clinical operations manages the daily operations of a healthcare facility or a specific department within a clinic or hospital. As a director of clinical operations, your responsibilities include scheduling staff to ensure proper coverage of patients and overseeing the productivity of your team to meet the organization's expectations. You define policies and procedures, facilitating further training when necessary. The director of clinical operations must also assess the performance of the medical team under your supervision regularly and mainstream processes when possible. Medical device manufacturers and pharmaceutical companies often hire a director of clinical operations to oversee research, lab, and testing operations.

What are the key skills and qualifications needed to thrive as a director of clinical operations?

To thrive as a Director of Clinical Operations, you need a robust background in clinical management, regulatory compliance, and healthcare administration, often supported by a relevant degree and substantial leadership experience. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications like PMP or CCRA are commonly required. Exceptional leadership, strategic thinking, and communication skills help drive teams, manage stakeholders, and oversee complex projects. These skills are critical for ensuring clinical programs run efficiently, meet regulatory standards, and deliver high-quality patient outcomes.

What is the difference between Director Clinical Operations vs Clinical Project Manager?

AspectDirector Clinical OperationsClinical Project Manager
CredentialsTypically requires advanced degrees (e.g., MS, PhD) and extensive industry experienceUsually holds a bachelor's or master's degree in a related field, with relevant project management certifications
Work EnvironmentOversees multiple projects and teams across departments, strategic planningManages individual clinical trials, coordinates project activities, and timelines
Employer & Industry UsageUsed in pharmaceutical, biotech, and healthcare companies for senior leadership rolesCommonly employed in clinical research organizations and pharmaceutical companies for trial management

The main difference is that the Director Clinical Operations focuses on strategic oversight and leadership across multiple clinical trials, while the Clinical Project Manager handles the day-to-day management of specific clinical studies. Both roles require strong industry knowledge, but the director position involves broader responsibilities and higher-level decision-making.

What does a director of clinical operations do?

A Director of Clinical Operations is responsible for overseeing the day-to-day management and strategic direction of clinical trials and research activities within healthcare organizations or pharmaceutical companies. They ensure that clinical studies are conducted efficiently, ethically, and in compliance with regulatory requirements. This role involves supervising teams, managing budgets, developing protocols, and liaising with stakeholders to ensure successful trial outcomes. Directors of Clinical Operations play a crucial role in bringing new medical treatments to market by ensuring studies run smoothly from start to finish.

How does a director of clinical operations typically collaborate with cross-functional teams to ensure successful clinical trial execution?

A Director of Clinical Operations regularly collaborates with cross-functional teams such as regulatory affairs, data management, medical affairs, and biostatistics to ensure clinical trials are executed on time, within budget, and in compliance with regulations. This role involves leading team meetings, aligning project timelines, and facilitating communication between internal stakeholders and external partners like CROs and vendors. Strong coordination skills are essential, as the Director must balance diverse priorities and resolve any operational issues that arise, ensuring all teams work toward shared objectives.
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Director Clinical Operations jobs near you
Infographic showing various Director Clinical Operations job openings in the United States as of August 2026, with employment types broken down into 85% Full Time, 12% Part Time, 1% Temporary, and 2% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.

Dir, Clinical Operations

Clinovo

Cambridge, MA • On-site

Other

Medical, Dental, Vision, Retirement, PTO

Re-posted 15 days ago

Job description

Position Overview
A growth-stage biotechnology company focused on innovative therapeutic development is seeking a highly motivated and detail-oriented Clinical Operations leader who thrives in lean, fast-moving environments and is energized by the opportunity to help build infrastructure, teams (direct and/or external relationships), and operational strategy around novel science.
The successful candidate will lead clinical operations for an autoimmune and immunology-focused development portfolio, with a particular emphasis on early-phase and operationally complex studies. Working closely with Clinical Development and broader cross-functional teams, this individual will drive operational strategy, study execution, and CRO/vendor oversight as programs launch across APAC and subsequently expand into the United States and Europe.
This role requires a leader who operates both strategically and tactically-developing scalable operational frameworks while remaining close enough to execution to resolve issues in real time.
The individual will serve as a key operational leader and cross-functional connector, partnering closely with Clinical Development, Clinical Operations, Translational Science, Medical Affairs, Regulatory Affairs, Biometrics, and Quality to ensure aligned and efficient global trial execution.
This opportunity is best suited for a sponsor-side clinical operations leader who takes strong ownership of study strategy, execution, and CRO accountability while fostering collaborative, high-performing partnerships with external vendors and service providers.
Key Responsibilities
  • Drive clinical operations strategy and execution for an autoimmune/immunology-focused clinical portfolio, beginning within APAC and expanding into the United States and Europe
  • Provide operational leadership across all stages of study execution, including feasibility, site selection, study start-up, enrollment strategy, monitoring oversight, vendor management, data quality, and study closeout
  • Build and maintain strategic relationships with investigators, institutions, early-phase units, and clinical trial networks across APAC, and establish equivalent partnerships as programs expand globally
  • Drive operational excellence and accountability across CROs, vendors, and study partners through proactive governance frameworks, performance metrics, and escalation processes
  • Oversee study timelines, budgets, enrollment forecasting, resource planning, and operational risk management to support delivery against program milestones
  • Partner cross-functionally with Clinical Development, Translational Science, Medical Affairs, Regulatory Affairs, Biometrics, and Quality to align scientific and operational priorities
  • Provide strategic oversight of site engagement and enrollment initiatives, particularly in immunology, autoimmune disease, and advanced therapeutic clinical settings
  • Ensure inspection readiness and compliance with ICH-GCP, regional and global regulatory requirements, and applicable clinical trial standards across multiple jurisdictions
  • Support development and scaling of internal clinical operations infrastructure, SOPs, processes, and operational best practices appropriate for a growing biotechnology organization
  • Directly manage, mentor, and develop clinical operations personnel while supporting growth and expansion of the broader clinical operations function across regions
  • Foster a collaborative, accountable, and execution-focused team culture
  • Contribute to strategic planning for future clinical programs, including operational scalability across additional indications and geographies
Required Qualifications
  • Bachelor's degree in life sciences, health sciences, or a related discipline; advanced degree preferred
  • 10+ years of progressive clinical operations experience within sponsor biotechnology and/or pharmaceutical organizations
  • Demonstrated experience within sponsor organizations where ownership of study strategy, vendor oversight, timelines, budgets, and overall trial execution accountability were core responsibilities
  • Significant experience leading global and/or multi-regional clinical trials, including early-phase (Phase I/II) studies, with demonstrated success operating across multiple regulatory jurisdictions
  • Strong operational leadership experience in immunology, autoimmune disease, cell therapy, gene therapy, or other advanced therapeutic modalities
  • Demonstrated sponsor-side experience overseeing CROs and external vendors, including governance, performance management, escalation management, and operational accountability
  • Strong understanding of APAC clinical trial regulations and operational frameworks, with working knowledge of-or demonstrated ability to support-US and European clinical trial requirements and global regulatory standards
  • Proven ability to build strategic relationships with investigators, institutions, and site networks across global regions
  • Experience operating successfully within lean or emerging biotech environments where flexibility, autonomy, and hands-on leadership are essential
  • Excellent leadership, communication, and stakeholder management skills with the ability to influence across organizational levels
  • Ability to travel domestically and internationally as required
Preferred Qualifications
  • Prior experience supporting cell therapy, CAR-T, gene therapy, mRNA, or other advanced therapy medicinal product (ATMP) studies
  • Experience supporting autoimmune disease or immunology clinical programs
  • Established relationships with investigative sites, clinical networks, and key opinion leaders within APAC and/or globally
  • Experience building or scaling clinical operations infrastructure within an emerging biotechnology company
  • Familiarity with translational-heavy or biomarker-driven clinical trial designs
  • Experience supporting global inspections or regulatory authority interactions
Benefits May Include
  • Equity participation and long-term incentive opportunities
  • Comprehensive medical, dental, and vision coverage for employees and eligible dependents
  • Retirement savings program with company contribution or matching opportunities
  • Generous paid time off, company holidays, and sick leave
  • Paid parental leave and family support benefits
  • Flexible or hybrid work arrangements to support work-life balance
  • Transportation and commuter assistance programs, where applicable

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