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Sr Manager Clinical Operations Jobs (NOW HIRING)

IQVIA

Sr. Manager, Clinical Operations

Washington, DC · On-site

$86K - $216K/yr

Support senior leadership on resourcing strategies and with local clients relationship. Essential ... clinical operations management. May collaborate with other clinical teams and other functional ...

ICON

Manager, Clinical Operations

Blue Bell, PA · On-site

Manager, Clinical Operations ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster. As a values ...

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$186.5K

How much do sr manager clinical operations jobs pay per year?

As of Jun 14, 2026, the average yearly pay for sr manager clinical operations in the United States is $98,039.00, according to ZipRecruiter salary data. Most workers in this role earn between $72,500.00 and $113,500.00 per year, depending on experience, location, and employer.

What are some common challenges faced by a Sr Manager Clinical Operations, and how can they be addressed?

A Sr Manager Clinical Operations often encounters challenges such as coordinating cross-functional teams, ensuring regulatory compliance, and managing multiple clinical trial timelines simultaneously. Balancing the needs of various stakeholders—such as sponsors, investigators, and regulatory bodies—requires strong communication and leadership skills. Staying organized with robust project management tools and fostering transparent communication within the team can help address these challenges effectively. Additionally, proactively identifying potential risks and implementing mitigation strategies is key to maintaining smooth clinical trial operations.

What is the difference between Sr Manager Clinical Operations vs Clinical Project Manager?

AspectSr Manager Clinical OperationsClinical Project Manager
CredentialsTypically requires a Bachelor's or Master's in Life Sciences, with experience in clinical operationsRequires similar educational background, often with certifications like PMP
Work EnvironmentOversees multiple projects, manages teams, and ensures compliance across clinical trialsFocuses on managing individual clinical projects, timelines, and deliverables
Employer & Industry UsageCommon in pharmaceutical, biotech, and CRO companies for operational leadershipUsed in similar settings, often as a project-focused role within clinical research teams

The Sr Manager Clinical Operations typically has broader responsibilities overseeing multiple projects and teams, while the Clinical Project Manager concentrates on managing specific clinical trials. Both roles require similar credentials and are vital in clinical research, but differ in scope and focus.

What are the key skills and qualifications needed to thrive as a Sr Manager Clinical Operations, and why are they important?

To thrive as a Sr Manager Clinical Operations, you need a strong background in clinical research, project management, and regulatory compliance, typically supported by a degree in life sciences or a related field and extensive experience in clinical trials. Familiarity with electronic data capture (EDC) systems, clinical trial management systems (CTMS), and GCP guidelines is essential, and certifications such as PMP or ACRP are often preferred. Exceptional leadership, strategic thinking, and communication skills help you effectively lead teams and manage complex projects. These capabilities are crucial for ensuring efficient trial execution, regulatory adherence, and the delivery of high-quality clinical outcomes.

What are Sr Manager Clinical Operations?

A Sr Manager Clinical Operations is a senior professional responsible for overseeing the planning, execution, and management of clinical trials and studies within a healthcare or pharmaceutical organization. They ensure that clinical projects are conducted efficiently, comply with regulatory standards, and meet organizational goals. This role involves leading clinical operations teams, managing budgets and timelines, and collaborating with cross-functional departments. Sr Managers also play a key role in process improvement and maintaining high standards of data quality and patient safety.
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Sr Manager Clinical Operations jobs near you
Infographic showing various Sr Manager Clinical Operations job openings in the United States as of June 2026, with employment types broken down into 16% As Needed, 39% Full Time, 42% Contract, and 3% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $98,039 per year, or $47.1 per hour.
Senior Manager, Clinical Operations

Senior Manager, Clinical Operations

Nuvalent, Inc.

Cambridge, MA • On-site, Remote

Other

Posted 19 days ago

Job description

The Role:

Reporting to the Associate Director, Clinical Operations, the Sr. Manager, Clinical Operations will ensure excellence in clinical trial planning, execution, and data collection, in accordance with regulatory guidelines. You will be working on a clinical study with responsibilities including site selection, contract negotiation, budget management, study start-up, conduct and close-out.  This role will collaborate with cross-functional study team as well as demonstrate excellent management of and partnership with CROs and vendors. The ideal candidate has a track record of executing complex, on-time clinical trials at a biotech/pharmaceutical company and delivering high quality clinical trial results.  

Responsibilities:

  • Contribute to one or multiple clinical studies and demonstrate thorough knowledge of clinical operations project management. Collaborate with cross-functional clinical study team to support clinical study delivery.
  • Evaluates, and ensures appropriate oversight of CROs and other external vendors.
  • Ensure clinical trials are executed according to scope of work, budget, timelines, KPIs, and corporate goals.
  • Establish and maintain effective communication and collaboration with functional area peers to meet clinical study objectives and support goals.
  • Identify risks and propose solutions to facilitate clinical studies.
  • Responsible for review and oversight of the study-level budget(s) and demonstrates accountability for the management of the budgets through managing the review and approval of contracts and/or work order changes; contribute to budget forecasting and accruals in collaboration with finance.
  • Oversee and manage the creation, maintenance, QC and close out of TMF activities.
  • Ensure appropriate oversight of enrollment, site activation and data collection milestones.
  • Contribute to and support team to ensure the completeness of study documents including, study protocol, investigator brochure, informed consent forms, clinical study reports and case report forms.
  • Collaborate with Data Management to ensure timely and efficient database lock. Participate in data review and reconciliation efforts.
  • Lead or co-lead department initiatives to support an expanding organization.
  • Travel may be required (10% - 15%).

Competencies Include:

  • Detail and process orientated, with excellent project management skills, including risk assessment and contingency planning.
  • Excellent problem solving, communication and organization skills.
  • Flexibility with changing priorities, ability to think critically, strong attention to detail, and ability to work well under pressure.
  • Ability to work in a collaborative environment and build effective working relationships across the organization.
  • Demonstrated leadership and ability to strategically plan, organize and manage multiple projects simultaneously.

 Qualifications:

  • At least 5 - 7 years of Clinical Operations experience.
  • Bachelor's degree or higher in a scientific or healthcare discipline preferred and relevant experience within the biotech, pharmaceutical, or CRO industry.
  • Extensive knowledge of current ICH-GCP guidelines.
  • Relevant experience managing early through late Phase clinical trials.
  • Demonstrated cross-functional leadership fostering team spirit and team motivation.
  • Capability to challenge status-quo using risk management approach.
  • Able to thrive in a remote/virtual environment.

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