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Sr Manager Clinical Operations information

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$98K

$186.5K

How much do sr manager clinical operations jobs pay per year?

As of Jul 6, 2026, the average yearly pay for sr manager clinical operations in the United States is $98,039.00, according to ZipRecruiter salary data. Most workers in this role earn between $72,500.00 and $113,500.00 per year, depending on experience, location, and employer.

What are some common challenges faced by a Sr Manager Clinical Operations, and how can they be addressed?

A Sr Manager Clinical Operations often encounters challenges such as coordinating cross-functional teams, ensuring regulatory compliance, and managing multiple clinical trial timelines simultaneously. Balancing the needs of various stakeholders—such as sponsors, investigators, and regulatory bodies—requires strong communication and leadership skills. Staying organized with robust project management tools and fostering transparent communication within the team can help address these challenges effectively. Additionally, proactively identifying potential risks and implementing mitigation strategies is key to maintaining smooth clinical trial operations.

What is the difference between Sr Manager Clinical Operations vs Clinical Project Manager?

AspectSr Manager Clinical OperationsClinical Project Manager
CredentialsTypically requires a Bachelor's or Master's in Life Sciences, with experience in clinical operationsRequires similar educational background, often with certifications like PMP
Work EnvironmentOversees multiple projects, manages teams, and ensures compliance across clinical trialsFocuses on managing individual clinical projects, timelines, and deliverables
Employer & Industry UsageCommon in pharmaceutical, biotech, and CRO companies for operational leadershipUsed in similar settings, often as a project-focused role within clinical research teams

The Sr Manager Clinical Operations typically has broader responsibilities overseeing multiple projects and teams, while the Clinical Project Manager concentrates on managing specific clinical trials. Both roles require similar credentials and are vital in clinical research, but differ in scope and focus.

What are the key skills and qualifications needed to thrive as a Sr Manager Clinical Operations, and why are they important?

To thrive as a Sr Manager Clinical Operations, you need a strong background in clinical research, project management, and regulatory compliance, typically supported by a degree in life sciences or a related field and extensive experience in clinical trials. Familiarity with electronic data capture (EDC) systems, clinical trial management systems (CTMS), and GCP guidelines is essential, and certifications such as PMP or ACRP are often preferred. Exceptional leadership, strategic thinking, and communication skills help you effectively lead teams and manage complex projects. These capabilities are crucial for ensuring efficient trial execution, regulatory adherence, and the delivery of high-quality clinical outcomes.

What are Sr Manager Clinical Operations?

A Sr Manager Clinical Operations is a senior professional responsible for overseeing the planning, execution, and management of clinical trials and studies within a healthcare or pharmaceutical organization. They ensure that clinical projects are conducted efficiently, comply with regulatory standards, and meet organizational goals. This role involves leading clinical operations teams, managing budgets and timelines, and collaborating with cross-functional departments. Sr Managers also play a key role in process improvement and maintaining high standards of data quality and patient safety.
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Sr Manager Clinical Operations jobs near you
Infographic showing various Sr Manager Clinical Operations job openings in the United States as of June 2026, with employment types broken down into 83% Full Time, 12% Part Time, and 5% Contract. Highlights an 86% Physical, 5% Hybrid, and 9% Remote job distribution, with an average salary of $98,039 per year, or $47.1 per hour.
Senior Manager, Clinical Operations

Senior Manager, Clinical Operations

Adams Clinical

Boston, MA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 4 days ago

Job description

Join Us in Shaping the Future of Clinical Research
Adams Clinical is a leading clinical trial site network committed to accelerating the development of life-changing medicines. Our mission is simple: deliver uncompromising data quality, safety, and diverse enrollment to advance healthcare. Our vision is to set the gold standard for clinical trial excellence. We believe our people make the difference. Guided by our core values-Scientific Rigor, Operational Excellence, Commitment to Sponsors and Participants, and Authentic Collaboration-we create an environment where meaningful work drives meaningful change.
At Adams Clinical, you'll find:
  • A culture of respect, transparency, and continuous improvement
  • Opportunities for professional growth and learning
  • A team dedicated to improving lives through innovation and integrity

If you're passionate about making an impact in clinical research and want to be part of a collaborative, mission-driven organization, we'd love to have you on our team.
Job Role
We are seeking a Senior Manager, Clinical Operations for a full-time role at our Boston location. The Senior Manager, Clinical Operations will oversee day-to-day site-level operations and provide leadership across study teams. This individual will be responsible for staff management, operational oversight, regulatory compliance, and ensuring high-quality trial execution that meets both sponsor expectations and business objectives.
Key Responsibilities:
Study Operations and Site Performance
  • Serve as primary point of contact for day-to-day site issues; monitor study activities, enrollment, visit schedules, and site performance metrics for both inpatient and outpatient studies.
  • Support subject recruitment, eligibility assessments, randomization, and oversee study processes including ALCOA-compliant documentation, study trackers, investigational product handling, and ensure proper handling of participant safety events and adverse events (SAE/AESI reporting).
  • Identify operational, regulatory, or safety risks, implement mitigation strategies with senior leadership, and escalate critical issues.
  • Work closely with the Inpatient Unit Manager and the Associate Director of Inpatient Clinical Operations to support and oversee the conduct and quality of all inpatient studies at the Watertown inpatient facility. Ensure alignment on workflows, study execution, and safety practices within the inpatient unit.
  • Collaborate with Finance to review Clinical Trial Agreement (CTA) invoicing, oversee participant reimbursement processes, and support site-level budget monitoring and forecasting to ensure financial compliance and operational efficiency.

Team Management and Development
  • Lead, train, and develop the Clinical Research Coordinators (CRCs), Research Assistants (RAs), and Laboratory Technicians; assign responsibilities and track staff involvement across studies.
  • Oversee the recruitment, hiring, and onboarding of key site personnel (PIs, clinicians, nurses, DSMs, CRCs, RAs) and conduct regular team huddles to review study progress.
  • Collaborate with leadership across departments and sites to coordinate resources, streamline processes, and drive operational excellence.
  • Work closely with the Director and Vice President of Clinical Operations along with leaders of other departments and sites to coordinate resources, streamline processes, and drive operational excellence. This position reports directly to the Director of Clinical Operations.

Facilities Oversight
  • Oversee facility and building maintenance, including office services, safety inspections, drug room security, and pest control, while ensuring efficient use of site space and adequate workspaces for staff.
  • Coordinate calibration of research equipment and support renovation, expansion, and relocation projects.
  • Manage local vendor contracts for study-related services, including laboratories and imaging.

Study Regulatory and Quality Oversight
  • Represent the site at PSSVs, SIVs, and serve as an expert on site resources and SOPs.
  • Collaborate with regulatory teams to build and amend study source documents.
  • Monitor site activities for protocol and regulatory compliance, implement corrective actions, and support internal quality assurance checks.
  • Assist with DEA communications and audit response preparation.

Sponsor Relations and Study Communication
  • Facilitate communication and collaboration between site teams, medical monitors, and senior leadership to address operational issues, share updates, and ensure alignment with study objectives.
  • Serve as a primary point of contact for sponsors, monitors, and other external stakeholders regarding operational and regulatory matters.
  • Generate and review site performance reports for leadership and sponsors.

Qualifications
  • Bachelor's degree required.
  • Minimum 2 years of people management experience in clinical research.
  • 5+ years of clinical research experience preferred; hands-on experience as a Clinical Research Coordinator is a plus.
  • Prior research site management experience is a plus
  • Knowledge of GCP, FDA regulations, and clinical trial protocols
  • Excellent communication, collaboration, and organizational skills
  • Strong decision-making and problem-solving skills
  • Ability to prioritize competing responsibilities in a fast-paced environment.

Pay: $120,000 - $140,000 per year
Benefits:
  • 401(k) matching
  • Medical, Dental &Vision insurance
  • Employee assistance program
  • Flexible spending account
  • Health insurance
  • Health savings account
  • Life insurance
  • Paid time off
  • Parental leave
  • Professional development assistance

Adams Clinical is committed to being an equal opportunity and affirmative action employer. We focus on hiring and nurturing top talent. All employment decisions, including recruitment, hiring, promotion, compensation, transfer, training, discipline, and termination, are made based on the candidate's or employee's qualifications relevant to the position. These decisions are made without regard to age, sex, sexual orientation, gender identity or expression, genetic information, race, color, creed, religion, ethnicity, national origin, citizenship, disability, marital status, military status, pregnancy, or any other legally protected status.
In compliance with federal law, all individuals hired must, as a condition of employment, provide documentation verifying their identity and authorization to work in the United States and complete Form I-9 within the required timeframe. Adams Clinical participates in E-Verify to confirm employment eligibility.

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