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Senior Director Clinical Operations Jobs (NOW HIRING)

taiho

Sr. Director, Clinical Operations

Pleasanton, CA · Hybrid

Finally, the Senior Director, Clinical Operations will oversee implementation of all clinical trial activities utilizing both internal and external resources. Performance Objectives: * Develops the ...

Noom US

Senior Director, Clinical Operations

New York, NY · On-site +1

$225K - $265K/yr

About the Role As we continue to grow, we're seeking a Senior Director, Clinical Operations to lead and scale our clinical operations function. Reporting to the SVP of Health Operations and Customer ...

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How much do senior director clinical operations jobs pay per year?

As of Jun 14, 2026, the average yearly pay for senior director clinical operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What are the primary responsibilities of a Senior Director Clinical Operations on a daily basis?

A Senior Director Clinical Operations typically oversees multiple clinical trial programs, ensuring they run efficiently, meet quality and compliance standards, and stay within budget. They provide leadership and direction to clinical operations teams, collaborate closely with cross-functional departments like regulatory affairs, data management, and medical affairs, and engage with external vendors or partners as needed. Regular responsibilities also include monitoring project progress, addressing operational challenges, managing timelines, and developing process improvements. This role is highly collaborative and requires the ability to make strategic decisions that impact the success of trial outcomes and organizational goals.

What is a Senior Director Clinical Operations job?

A Senior Director of Clinical Operations oversees the planning, execution, and management of clinical trials to ensure compliance with regulatory guidelines and company objectives. They lead cross-functional teams, manage budgets, and develop strategies to optimize trial efficiency. This role requires strong leadership, strategic planning, and operational expertise to drive successful trial outcomes. They also collaborate with stakeholders, monitor trial progress, and implement process improvements.

What are the key skills and qualifications needed to thrive in the Senior Director Clinical Operations position, and why are they important?

To thrive as a Senior Director Clinical Operations, you need extensive experience in clinical research or healthcare management, a strong understanding of regulatory requirements (such as GCP and ICH), and typically hold an advanced degree in life sciences or a related field. Familiarity with clinical trial management systems (CTMS), project management software, and regulatory submission tools is essential, and a certification such as PMP or ACRP can be advantageous. Outstanding leadership, strategic thinking, and communication skills help you effectively manage teams and build relationships with stakeholders. These competencies ensure operational excellence, compliant trial execution, and the ability to lead large, complex projects to successful outcomes.

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Senior Director Clinical Operations jobs near you
Infographic showing various Senior Director Clinical Operations job openings in the United States as of June 2026, with employment types broken down into 8% As Needed, 76% Full Time, 12% Part Time, and 4% Contract. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.
Sr. Director Clinical Operations

Sr. Director Clinical Operations

Scientific Search

Boston, MA • Remote

$250K/yr

Other

Posted yesterday

Job description

Senior Director, Clinical Operations – GI
Location: Remote
Reports to: Vice President Clinical Operations
Salary: $210-250k base plus bonus and equity
Join a well-funded, clinical-stage biotechnology company advancing innovative therapies for patients with serious immunology and inflammatory diseases. Backed by significant long-term investment and led by an experienced team with a track record of successfully developing and commercializing medicines, this organization combines the scientific rigor of large pharma with the agility and speed of a biotech startup. With multiple programs advancing across respiratory and gastrointestinal indications, this is a unique opportunity to play a highly visible leadership role and directly impact the development of potentially transformative therapies.
Position Summary
The Senior Director, Clinical Operations will provide strategic and operational leadership across gastrointestinal clinical development programs, overseeing the execution of Phase 1–3 clinical trials. This individual will partner closely with executive leadership and cross-functional teams to drive study execution, vendor oversight, and operational excellence while helping build scalable processes to support future growth.
Key Responsibilities
  • Lead operational strategy and execution for Phase 1–3 GI clinical trials.
  • Oversee study timelines, budgets, enrollment plans, and key milestones to ensure successful delivery.
  • Manage CROs and external vendors, establishing clear expectations, KPIs, and accountability.
  • Identify and mitigate operational risks while maintaining compliance with ICH-GCP and regulatory requirements.
  • Partner cross-functionally with Clinical Development, Biometrics, Regulatory, Medical Writing, Clinical Supply, and Quality to ensure seamless trial execution.
  • Contribute operational expertise to protocol development, study feasibility, and development planning.
  • Drive inspection readiness and maintain high-quality standards throughout study conduct.
  • Support the continued evolution of Clinical Operations infrastructure, processes, and best practices within a growing biotech environment.
  • Mentor team members and help foster a collaborative, high-performance culture.
  • Present program updates, milestones, risks, and operational strategies to senior leadership.
Requirements
  • Bachelor’s degree required; advanced scientific or healthcare degree preferred.
  • 8+ years of clinical operations experience within biotech, pharmaceutical, or CRO environments.
  • Experience leading Phase 1–3 clinical trials.
  • GI, immunology, inflammation, or related therapeutic area experience strongly preferred.
  • Proven CRO and vendor management experience.
  • Strong understanding of ICH-GCP, FDA regulations, and global clinical trial execution.
  • Demonstrated success operating within fast-paced biotech environments.
  • Excellent leadership, communication, and cross-functional collaboration skills.
  • 5+ years of people management experience preferred.
  • Ability to travel up to 20%.
Why This Opportunity?
  • High visibility role with direct interaction with executive leadership.
  • Opportunity to shape and build clinical operations infrastructure in a rapidly growing organization.
  • Strong financial backing and commitment to advancing innovative therapies.
  • Expanding pipeline focused on areas of significant unmet medical need.
  • Fully remote work environment with meaningful influence on corporate and clinical strategy.
How To Apply
We’d love to see your resume, but we don’t need it to have a conversation.
Email tom@scientificsearch.com or message me directly if you’d like to learn more.

Apply