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Full Time Director Clinical Operations Jobs (NOW HIRING)

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Director, Clinical Operations

Boston, MA · On-site

As the Director, Clinical Operations, you will lead the clinical operations function responsible ... The U.S. base salary range for this full-time position is $210,000-$230,000 Salary ranges are ...

Jade Biosciences

$215K - $240K/yr

Role Overview The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders ...

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How much do full time director clinical operations jobs pay per year?

As of Aug 13, 2026, the average yearly pay for full time director clinical operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What is the difference between Full Time Director Clinical Operations vs Clinical Project Manager?

AspectFull Time Director Clinical OperationsClinical Project Manager
CredentialsAdvanced degrees (e.g., MD, PhD, or related), extensive industry experienceBachelor's or Master's degree in life sciences or related field, relevant project management certifications
Work EnvironmentOversees multiple projects, manages teams, strategic planningManages individual clinical trials, coordinates project activities
Employer & Industry UsagePharmaceutical, biotech companies, CROsPharmaceutical, biotech companies, CROs

The Full Time Director Clinical Operations focuses on strategic oversight and leadership of clinical operations across multiple projects, requiring higher-level credentials and experience. In contrast, the Clinical Project Manager handles the day-to-day management of specific clinical trials, with a more tactical role. Both roles are essential in the clinical research industry but differ in scope and responsibilities.

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Full Time Director Clinical Operations jobs near you
Infographic showing various Full Time Director Clinical Operations job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 90% In-person, and 10% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.

Director, Clinical Operations

Incyte Corporation

Wilmington, DE • On-site

Full-time

This job post has expired 2 days ago. Applications are no longer accepted.

Job description

Overview
A global biopharmaceutical company on a mission to Solve On, Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery, development, and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology, Oncology and Inflammation and Autoimmunity
Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.
Job Summary (Primary function)
The Director, Clinical Operations provides strategic, operational, and people leadership for global Phase I-III clinical trials, including first-in-human and pivotal studies. This role oversees end-to-end clinical trial execution, ensures compliance with FDA/EMEA regulations and ICH-GCP, manages CROs and vendors, and partners cross-functionally to deliver high-quality clinical programs aligned with corporate objectives. The Director also leads Clinical Operations staff, drives operational excellence, and contributes to program-level planning across Incyte's Hematology, Oncology, and Inflammation/Autoimmunity portfolio.
Essential Functions of the Job (Key responsibilities)
  • Provide strategic operational leadership for assigned clinical programs, including feasibility, resource forecasting, and long-range planning.
  • Contribute to program-level strategy, timelines, budgets, and operational deliverables in alignment with corporate goals.
  • Ensure harmonized operational plans and high-quality data across global trials.
  • Lead end-to-end planning, implementation, and management of global Phase I-III trials, including first-in-human studies.
  • Oversee day-to-day clinical operations to ensure adherence to timelines, budgets, SOPs, ICH-GCP, and country-specific regulations.
  • Manage investigational product accountability and reconciliation processes.
  • Support preparation of safety updates, interim analyses, and final clinical study reports; resolve data discrepancies.
  • Partner closely with Clinical Development, Regulatory, Biometrics, Supply Chain, and other internal teams to achieve study objectives.
  • Lead and/or participate in cross-functional study team meetings, ensuring alignment and timely decision-making.
  • Collaborate with senior management to determine clinical supply requirements and operational strategy.
  • Select, negotiate, and manage CROs and external vendors (central labs, EDC providers, patient recruitment partners, etc.).
  • Develop RFPs, conduct cost analyses, and ensure vendor performance meets quality, timeline, and budget expectations.
  • Provide strategic oversight of CRO governance and issue resolution.
  • Contribute to the development and review of protocols, amendments, ICFs, CRFs, study guides, operational plans, and charters.
  • Participate in preparation of INDs, Investigator Brochures, regulatory briefing documents, and other clinical submissions.
  • Ensure operational feasibility and high-quality clinical data across studies.
  • Build and maintain strong relationships with investigator sites, KOLs, patient advocacy groups, and referral networks.
  • Support site engagement strategies to ensure enrollment targets and study goals are met.
  • Recruit, manage, and mentor Clinical Trial Managers, Clinical Trial Specialists, and other direct reports.
  • Provide clear objectives, ongoing coaching, and performance evaluations.
  • Foster a culture of engagement, accountability, and collaboration.
  • Provide regular updates and status reports to senior leadership.

Qualifications (Minimal acceptable level of education, work experience, and competency)
  • Bachelor's degree in Life Sciences or related field required.
  • 10+ years of clinical operations experience in biopharma or biotech.
  • Minimum 5 years of direct clinical study management experience.
  • Extensive experience managing global Phase I-III trials; first-in-human experience strongly preferred.
  • Oncology experience preferred; rare disease experience desirable.
  • Global clinical development experience preferred.
  • Strong knowledge of FDA/EMEA regulations, ICH-GCP, and clinical trial methodology.
  • Proven ability to manage CROs and external vendors.
  • Experience with clinical systems (EDC, CTMS, eTMF) and operational documentation.
  • Demonstrated ability to manage budgets, timelines, and complex operational plans.
  • Proven ability to lead and develop high-performing teams.
  • Strong organizational, time-management, and problem-solving skills.
  • Excellent written and verbal communication skills.
  • Thrives in a collaborative, fast-paced, high-energy environment.
  • Ability to travel domestically and internationally (up to 30%).

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.
We Respect Your Privacy
Learn more at: http://www.incyte.com/privacy-policy
The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate.
During the process, you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process here.
You may have the right to access, delete, restrict, edit, move, or object to the use of your personal data. You may also have a right to report concerns to the authority responsible for data privacy in the country where the position is based or where you live or work.
You can learn more about Incyte's data protection practices here. By accessing this link you can learn about the types of personal data we collect, how we use it, whether collection and processing is optional, sources of the personal data we process, how it is shared, where it is stored or transferred to, how long we keep it, and contact information for Incyte, Incyte's data protection officer, and your supervisory authority (if applicable).
Please contact privacy@incyte.com if you have any questions or concerns or would like to exercise your rights.
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