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Director Clinical Operations Jobs (NOW HIRING)

Gilead

Director, Clinical Operations

Foster City, CA

$210K - $272K/yr

Experience managing cross-functional teams or work groups as well as direct reports. * Demonstrated understanding of pharmaceutical regulatory requirements and impact on development of clinical ...

Gilead

Director, Clinical Operations

Parsippany, NJ

$210K - $272K/yr

Experience managing cross-functional teams or work groups as well as direct reports. * Demonstrated understanding of pharmaceutical regulatory requirements and impact on development of clinical ...

Gilead

Director, Clinical Operations

Foster City, CA · On-site

$210K - $272K/yr

Experience managing cross-functional teams or work groups as well as direct reports. * Demonstrated understanding of pharmaceutical regulatory requirements and impact on development of clinical ...

Immatics NV

Director, Clinical Operations Lead

Houston, TX · On-site

$215K - $260K/yr

The Director, Clinical Operations Lead will be responsible for the oversight, execution, and operational management of global clinical trials in support of our clinical development programs. Schedule ...

Immatics

Director, Clinical Operations Lead

Houston, TX

$215K - $260K/yr

The Director, Clinical Operations Lead will be responsible for the oversight, execution, and operational management of global clinical trials in support of our clinical development programs.   ...

taiho

Sr. Director, Clinical Operations

Pleasanton, CA · Hybrid

Finally, the Senior Director, Clinical Operations will oversee implementation of all clinical trial activities utilizing both internal and external resources. Performance Objectives: * Develops the ...

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Director Clinical Operations information

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How much do director clinical operations jobs pay per year?

As of Jun 28, 2026, the average yearly pay for director clinical operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What Does a Director of Clinical Operations Do?

A director of clinical operations manages the daily operations of a healthcare facility or a specific department within a clinic or hospital. As a director of clinical operations, your responsibilities include scheduling staff to ensure proper coverage of patients and overseeing the productivity of your team to meet the organization's expectations. You define policies and procedures, facilitating further training when necessary. The director of clinical operations must also assess the performance of the medical team under your supervision regularly and mainstream processes when possible. Medical device manufacturers and pharmaceutical companies often hire a director of clinical operations to oversee research, lab, and testing operations.

What are the key skills and qualifications needed to thrive as a Director of Clinical Operations, and why are they important?

To thrive as a Director of Clinical Operations, you need a robust background in clinical management, regulatory compliance, and healthcare administration, often supported by a relevant degree and substantial leadership experience. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications like PMP or CCRA are commonly required. Exceptional leadership, strategic thinking, and communication skills help drive teams, manage stakeholders, and oversee complex projects. These skills are critical for ensuring clinical programs run efficiently, meet regulatory standards, and deliver high-quality patient outcomes.

What is the difference between Director Clinical Operations vs Clinical Project Manager?

AspectDirector Clinical OperationsClinical Project Manager
CredentialsTypically requires advanced degrees (e.g., MS, PhD) and extensive industry experienceUsually holds a bachelor's or master's degree in a related field, with relevant project management certifications
Work EnvironmentOversees multiple projects and teams across departments, strategic planningManages individual clinical trials, coordinates project activities, and timelines
Employer & Industry UsageUsed in pharmaceutical, biotech, and healthcare companies for senior leadership rolesCommonly employed in clinical research organizations and pharmaceutical companies for trial management

The main difference is that the Director Clinical Operations focuses on strategic oversight and leadership across multiple clinical trials, while the Clinical Project Manager handles the day-to-day management of specific clinical studies. Both roles require strong industry knowledge, but the director position involves broader responsibilities and higher-level decision-making.

What does a Director of Clinical Operations do?

A Director of Clinical Operations is responsible for overseeing the day-to-day management and strategic direction of clinical trials and research activities within healthcare organizations or pharmaceutical companies. They ensure that clinical studies are conducted efficiently, ethically, and in compliance with regulatory requirements. This role involves supervising teams, managing budgets, developing protocols, and liaising with stakeholders to ensure successful trial outcomes. Directors of Clinical Operations play a crucial role in bringing new medical treatments to market by ensuring studies run smoothly from start to finish.

How does a Director of Clinical Operations typically collaborate with cross-functional teams to ensure successful clinical trial execution?

A Director of Clinical Operations regularly collaborates with cross-functional teams such as regulatory affairs, data management, medical affairs, and biostatistics to ensure clinical trials are executed on time, within budget, and in compliance with regulations. This role involves leading team meetings, aligning project timelines, and facilitating communication between internal stakeholders and external partners like CROs and vendors. Strong coordination skills are essential, as the Director must balance diverse priorities and resolve any operational issues that arise, ensuring all teams work toward shared objectives.
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Director Clinical Operations jobs near you
Infographic showing various Director Clinical Operations job openings in the United States as of June 2026, with employment types broken down into 96% Full Time, 3% Part Time, and 1% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.
Associate Director, Clinical Operations

Associate Director, Clinical Operations

Transcend Therapeutics

New York, NY • On-site, Remote

$180K - $210K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 18 days ago

Job description

Position Details
  • Title: Associate Director, Clinical Operations
  • Location: New York City preferred (we're open to remote arrangements for exceptional candidates)

Company Overview
Founded in 2021, Transcend Therapeutics is a late-clinical-stage neuroscience company developing rapid-acting treatments for neuropsychiatric diseases. Our lead asset TSND-201, a rapid-acting neuroplastogen, is the first and only product to demonstrate rapid, robust, and durable therapeutic effects in PTSD. TSND-201 was granted Breakthrough Therapy designation by the FDA based on Phase 2 results, and we have aligned on a Phase 3 program for TSND-201 in PTSD. Transcend is backed by leading life sciences investors and driven by a mission to create treatments for the millions of people for whom current psychiatric medicines have not worked.
About the Role
The Associate Director (AD), Clinical Operations is a key member of the Clinical Operations team, with responsibility for overseeing the execution of Transcend's clinical trials. The AD will help drive trial operational strategy. The AD will manage essential duties and responsibilities as independently as possible, with guidance and oversight provided by a Senior Director, Clinical Operations when needed.
This position is highly visible in a small, growing organization which may provide for the opportunity for rapid advancement. A successful AD is forward thinking, takes initiative, and leads with the end in mind. This position will report to the Senior Director, Clinical Operations.
Key responsibilities will include:
  • Support the Clinical Trial Manager with planning and strategy for implementation and execution of assigned clinical trials from study startup through close-out
  • Oversee day-to-day operations of assigned clinical trials including team interactions with study sites and vendors and act as an escalation point for key issues
  • Identify, prepare, and implement departmental process improvement initiatives to improve operational efficiencies
  • Provide expertise for drafting, finalization and implementation of clinical documents (ie, Protocol, Clinical Monitoring Plan)
  • Oversee various activities and cross-functional collaboration of assigned clinical trials (e.g., monitoring, data management, drug supply logistics, labs, recruitment)
  • Manage direct report(s) by providing leadership, vision and mentoring
  • Proactively identify clinical data trends and escalate as needed
  • Ensure Trial Master File (TMF) maintains regulatory compliance
  • Support creation, review, and revision of clinical SOPs
  • Ensure that the clinical trials are conducted in a timely fashion and in compliance with SOPs, GCP, regulatory guidelines, company goals, and budget
  • All other duties as required

This is a great opportunity to step into a high-impact, high-visibility role on the early team of Transcend Therapeutics. We offer competitive cash and equity compensation; medical, dental, and vision insurance; 401k; unlimited vacation and sick time; and more.
The salary range for this role is $180,000 to $210,000, plus equity and benefits.
Experience Requirements
  • Bachelor's degree, preferably in a life science
  • At least 7 years of clinical trial experience within a pharmaceutical company or CRO and at least 4 years in a managerial position
  • Experience managing direct reports
  • Proficient knowledge of GCP/ICH, drug development process, clinical operations
  • Experience executing clinical trials in a small team or at a small pharmaceutical company is preferred
  • Experience conducting studies in psychiatry-related indications is preferred
  • Previous clinical monitoring experience is preferred

Key Competency Requirements
  • Excellent verbal, written, communication and interpersonal skills
  • Detail-oriented, with a desire to 'get in the weeds' and understand the nuances
  • Flexible, able to pivot when needed in a fast-paced environment
  • Able to align with company goals and focus on the big picture
  • Able to effectively communicate and collaborate across functions and job levels
  • Internally motivated, with a passion for mental health
  • Routinely takes initiative

Travel Required
  • Domestic and international travel may be required (approximately 10-25%)

We are committed to building a diverse, inclusive and talented team, free from discrimination. If you're excited about our mission but don't meet 100% of the qualifications above, we encourage you to apply.
Transcend Values
Operate with good intent. Above all, we aim to reduce suffering. We must remain selfless in pursuit of that noble goal, acting with good intent and assuming the same in our partners and peers.
Proceed with Passion. We're working to usher in an era where people with mental illness have safe and easy access to the treatments they need. Fulfilling that mission demands creative ideas, camaraderie among collaborators, and an understanding that we are all responsible for our individual and team success.
Be willing to work-and learn-together. The problems we're working to solve are complex, and no one person has every solution. Making the best decision as a team is more important than being individually "right." The diversity of our backgrounds and experiences is a strength; when all of those views are synthesized, we can develop new solutions and make better decisions.
Stay focused and flexible. Resourcefulness plays a major part in our success; we can't let unexpected set-backs derail our progress. Think creatively, act ethically, and find a way to get it done.

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