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Vp Technical Operations Jobs (NOW HIRING)

Scorpion Therapeutics

VP, Technical Operations

Waltham, MA · On-site

$291 - $360/hr

Summary The Vice President, Technical Operations will lead end-to-end CMC Technical Operations strategy across Drug Substance, Drug Product, and CMC Program Management, advancing small-molecule ...

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Stackinfra

Vice President, Technical Operations

Denver, CO · On-site +1

$216K - $249K/yr

STACK is looking for a Vice President of Technical Operations to support all data centers across the Americas portfolio. As a leader within STACK's Operations team, the Vice President of Technical ...

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How much do vp technical operations jobs pay per year?

As of Aug 30, 2026, the average yearly pay for vp technical operations in the United States is $155,780.00, according to ZipRecruiter salary data. Most workers in this role earn between $115,500.00 and $185,000.00 per year, depending on experience, location, and employer.

What does a VP of Technical Operations do?

A VP of Technical Operations oversees the technical aspects of an organization’s operations, ensuring that technology infrastructure and processes support business goals. They manage teams responsible for IT, systems administration, network operations, and sometimes software deployment or technical support. Their role includes developing strategies to improve efficiency, implementing best practices, and coordinating with other departments to align technical initiatives with company objectives. They also play a key role in budgeting, vendor management, and maintaining system security and compliance.

What are some common challenges faced by a VP of Technical Operations, and how can one effectively address them?

A VP of Technical Operations often encounters challenges such as aligning technical teams with business objectives, managing cross-departmental communication, and ensuring operational efficiency during periods of rapid growth. Effectively addressing these challenges requires strong leadership, strategic planning, and a focus on building collaborative relationships across engineering, IT, and product teams. Regularly reviewing processes, investing in staff development, and leveraging data-driven decision-making can help ensure that operations remain streamlined and adaptive to changing business needs.

What are the key skills and qualifications needed to thrive as a VP of Technical Operations, and why are they important?

To thrive as a VP of Technical Operations, you need deep expertise in operations management, technical infrastructure, and strategic planning, often backed by a degree in engineering or a related field and significant leadership experience. Familiarity with systems like ITIL, Six Sigma, cloud platforms, and enterprise resource planning (ERP) tools, as well as relevant certifications, is highly valuable. Exceptional leadership, communication, and problem-solving skills help drive cross-functional teams and align technology with business goals. These abilities are crucial for ensuring operational excellence, innovation, and scalable growth within an organization.
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Vp Technical Operations jobs near you
Infographic showing various Vp Technical Operations job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 11% Part Time, and 1% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $155,780 per year, or $74.9 per hour.

VP, Technical Operations

Waltham, MA • On-site

Scorpion Therapeutics
51 - 200 employees
Learn more about Scorpion Therapeuticsexternal

$291 - $360/hr

Other

Medical, Dental, Vision, Retirement, PTO

Posted yesterday

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Job description

Summary

The Vice President, Technical Operations will lead end-to-end CMC Technical Operations strategy across Drug Substance, Drug Product, and CMC Program Management, advancing small-molecule products from candidate selection and IND-enabling development through clinical development, registration, validation, commercial launch, ongoing manufacturing, and lifecycle management.

Responsibilities
  • Lead and develop Technical Operations and CMC Program Management; integrate/prioritize/execute Drug Substance, Drug Product, and cross-functional CMC activities across the product lifecycle.
  • Develop and execute phase-appropriate CMC strategies (Drug Substance, Drug Product, analytical development, manufacturing, controls, stability, validation, regulatory CMC, supply) from IND-enabling through registration, commercialization, and post-approval lifecycle management.
  • Provide technical leadership for small-molecule Drug Product development (formulation/process development, scale-up, technology transfer, characterization, control strategy, validation/PPQ, commercial readiness).
  • Provide oversight for Drug Substance development/manufacturing (scale-up, technology transfer, validation, control strategy, commercial readiness, lifecycle support).
  • Ensure CMC Program Management across the portfolio (deliverables, dependencies, critical paths, risks, resources, budgets, governance, decisions).
  • Oversee CDMOs/external manufacturing partners for development, validation, and clinical/commercial manufacturing.
  • Lead commercial manufacturing and lifecycle management (investigations, CAPAs, change controls, improvements, site transfers, continued process verification, supply continuity).
  • Partner with Supply Chain, Regulatory Affairs, Quality, and Program leadership to meet FDA/ICH/global regulatory and cGMP expectations.
  • Represent Technical Operations in cross-functional teams, executive governance, due diligence, portfolio planning, and risk management.
  • Manage resources, operating plans, budgets, and portfolio priorities.
Qualifications
  • MS/Ph.D. in Pharmaceutics/Pharmaceutical Sciences/Chemical Engineering/Chemistry (or related) with progressive pharmaceutical industry experience for a VP-level role.
  • Extensive small-molecule development/manufacturing experience; deep Drug Product expertise (formulation/process development, scale-up, technology transfer, characterization, control strategy, validation/PPQ, regulatory approval, commercial launch, ongoing manufacturing), including leading PPQ/commercial validation at external sites.
  • Broad Drug Substance technical knowledge to lead and challenge an experienced organization.
  • Demonstrated end-to-end CMC strategy development and integration across Drug Substance, Drug Product, analytical, regulatory, quality, manufacturing, and supply.
  • Strong CMC program/portfolio management (risks, dependencies, resources, budgets, timelines, governance, executive decision support).
  • Significant CDMO/external manufacturing partner management experience.
  • Strong cGMP and FDA/ICH/global regulatory knowledge; experience supporting INDs, NDAs, and post-approval submissions.
  • Ability to lead multidisciplinary technical teams and influence senior stakeholders.
  • Small-molecule Drug Product development across multiple dosage forms (oral solids and liquids).
  • Commercial lifecycle management and global manufacturing network experience (post-approval changes, site transfers, optimization, supply risk, international submissions).
  • Technical due diligence experience for licensing/acquisitions/partnerships.
Compensation and Benefits
  • Targeted Base Salary: $291,349 USD - $359,902 USD.
  • Additional benefits include health care, vision, dental, retirement, PTO, etc.
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