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Director Clinical Operations Jobs (NOW HIRING)

Jade Biosciences

$215K - $240K/yr

Role Overview The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders ...

Doist

Director, Clinical Operations

Boston, MA · On-site

$215 - $240/hr

Role Overview The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders ...

Doist

Director, Clinical Operations

San Francisco, CA · On-site

$215 - $240/hr

Role Overview The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders ...

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Director Clinical Operations information

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How much do director clinical operations jobs pay per year?

As of Aug 30, 2026, the average yearly pay for director clinical operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What does a director of clinical operations do?

A director of clinical operations manages the daily operations of a healthcare facility or a specific department within a clinic or hospital. As a director of clinical operations, your responsibilities include scheduling staff to ensure proper coverage of patients and overseeing the productivity of your team to meet the organization's expectations. You define policies and procedures, facilitating further training when necessary. The director of clinical operations must also assess the performance of the medical team under your supervision regularly and mainstream processes when possible. Medical device manufacturers and pharmaceutical companies often hire a director of clinical operations to oversee research, lab, and testing operations.

What does a director of clinical operations do?

A Director of Clinical Operations is responsible for overseeing the day-to-day management and strategic direction of clinical trials and research activities within healthcare organizations or pharmaceutical companies. They ensure that clinical studies are conducted efficiently, ethically, and in compliance with regulatory requirements. This role involves supervising teams, managing budgets, developing protocols, and liaising with stakeholders to ensure successful trial outcomes. Directors of Clinical Operations play a crucial role in bringing new medical treatments to market by ensuring studies run smoothly from start to finish.

What are the key skills and qualifications needed to thrive as a director of clinical operations?

To thrive as a Director of Clinical Operations, you need a robust background in clinical management, regulatory compliance, and healthcare administration, often supported by a relevant degree and substantial leadership experience. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) tools, and certifications like PMP or CCRA are commonly required. Exceptional leadership, strategic thinking, and communication skills help drive teams, manage stakeholders, and oversee complex projects. These skills are critical for ensuring clinical programs run efficiently, meet regulatory standards, and deliver high-quality patient outcomes.

How does a director of clinical operations typically collaborate with cross-functional teams to ensure successful clinical trial execution?

A Director of Clinical Operations regularly collaborates with cross-functional teams such as regulatory affairs, data management, medical affairs, and biostatistics to ensure clinical trials are executed on time, within budget, and in compliance with regulations. This role involves leading team meetings, aligning project timelines, and facilitating communication between internal stakeholders and external partners like CROs and vendors. Strong coordination skills are essential, as the Director must balance diverse priorities and resolve any operational issues that arise, ensuring all teams work toward shared objectives.

What is the difference between Director Clinical Operations vs Clinical Project Manager?

AspectDirector Clinical OperationsClinical Project Manager
CredentialsTypically requires advanced degrees (e.g., MS, PhD) and extensive industry experienceUsually holds a bachelor's or master's degree in a related field, with relevant project management certifications
Work EnvironmentOversees multiple projects and teams across departments, strategic planningManages individual clinical trials, coordinates project activities, and timelines
Employer & Industry UsageUsed in pharmaceutical, biotech, and healthcare companies for senior leadership rolesCommonly employed in clinical research organizations and pharmaceutical companies for trial management

The main difference is that the Director Clinical Operations focuses on strategic oversight and leadership across multiple clinical trials, while the Clinical Project Manager handles the day-to-day management of specific clinical studies. Both roles require strong industry knowledge, but the director position involves broader responsibilities and higher-level decision-making.

Is a director of clinical operations a high position?

A director of clinical operations is a senior leadership role responsible for overseeing clinical trial activities, managing teams, and ensuring regulatory compliance. It is considered a high-level position within the healthcare and pharmaceutical industries, often requiring extensive experience and strategic skills.
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Director Clinical Operations jobs near you
Infographic showing various Director Clinical Operations job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 11% Part Time, and 1% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.

Director, Clinical Operations

Jade Biosciences

On-site, Remote

$215K - $240K/yr

Full-time

Re-posted 2 days ago

Job description

About Jade Biosciences
Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade's lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade's pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development. Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. For more information, visit JadeBiosciences.com and follow the Company on LinkedIn.
Role Overview
The Director, Clinical Operations will oversee the strategic and operational execution of clinical trials, leading cross-functional teams and collaborating with internal stakeholders and external vendors. This individual will manage trial budgets, vendor selection, and risk mitigation while contributing technical input to key clinical documents. This individual will also mentor staff, foster strong team and cross-functional relationships, and nimbly adapt in our dynamic organization. With proven leadership, financial acumen, and problem-solving skills, this individual will thrive in Jade's dynamic environment and evolve to support broader corporate initiatives. This is an exciting opportunity to make significant contributions to Jade's immunology pipeline, leading trials from first in human single site to global (APAC, LATAM, etc.) phase 3, as assigned.
Key Responsibilities
  • Performs role of Clinical Operations trial lead for assigned trials and leads cross-functional Study Execution Teams
  • Develops and executes trial operational strategies and partners cross-functionally to drive trial execution forward; provides strategic and technical recommendations to senior leadership
  • Directs the selection of CROs and other vendors (IxRS, Central Lab, ancillary/tech vendors), directs development of vendor Scopes of Work (SOW), scope changes, budgets, and vendor payments and partners with CROs and other vendors to deliver on study execution
  • Creates and tracks clinical trial budgets
  • Directs risk mitigation, escalation, and resolution activities both internally and with sites and vendors
  • Directs technical and strategic input into the development of clinical documents (protocols, monitoring plans, informed consent forms, investigator brochures, clinical study reports)
  • Builds relationships with clinical sites, vendors, and key stakeholders and maintains an understanding of the external landscape and adjusts plans accordingly
  • Represents Clinical Operations in cross-functional activities and supports development and management of the Clinical Operations function
  • Mentors more junior team members such as Clinical Trial Associates
  • Effectively builds strong internal teams and cross-functional relationships and demonstrates leadership and team building skills, along with success in proactive risk mitigation and problem solving
  • Flexible and creative in meeting the needs and challenges of a growing, dynamic company and demonstrates excellent problem-solving abilities
  • Strong financial acumen with outstanding track record of building budgets and managing expenses to budget
  • Contributes to corporate activities, including preparation of materials for Executive Team and Board of Director meeting materials

Qualifications
  • Bachelors + 15 years of related experience, or Masters + 12 years of related experience
  • 10+ years of clinical research experience, including 7+ years of trial management within a biopharmaceutical company; 5+ years within a small/startup company is a plus
  • Exceptional clinical trial management skills with a focus on strategic oversight of trial execution on time and on budget, study coordinator and/or site monitoring experience a plus
  • Extensive phase 1 through phase 3, global trial management experience
  • Immunology and/or rare disease trial management experience
  • Extensive experience selecting and managing vendors, including CROs, labs, IxRS, EDC, and ancillary technology/applications (e.g. eDiaries, eConsent, apps, etc)
  • Thorough knowledge and understanding of FDA and ICH Guidelines, GCP, medical terminology, and clinical trials
  • Detailed understanding of all aspects of clinical protocol design, implementation, IND/BLA/NDA submissions, and overall drug development
  • Experience managing, coaching, and mentoring personnel
  • Excellent communication, organizational, negotiation, and interpersonal skills with a strong reputation for collaboration

Position Location
This is a remote role; periodic travel to team and company events is required.
The anticipated salary range for candidates for this role is $215,000 - $240,000 The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography.
As part of the I-9 verification of authorization to work in the United States, Jade Bioscience participates in E-Verify. To learn more about E-Verify please review this poster.
Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

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