Scientist I, Computational Biology

Company Overview

Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Bayer and Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.

Position Summary

We are seeking a talented and motivated Computational Biology Scientist with strong collaboration and communication skills to join the Genomics and Computational Biology team at CRISPR therapeutics. A scientist in this role will tackle challenging bioinformatics and computational biology problems and work collaboratively on genomics activities that support the development of transformative CRISPR/Cas9-based gene editing therapies.

Responsibilities

• Perform or lead genomics activities to support gene-editing therapeutic programs, from research through clinical trial applications, while clearly communicating and meeting timeline goals
• Conduct investigations into and develop deep understanding of performance of NGS-based assays and computational tools for CRISPR on- and off-target editing
• Perform computational analyses in a cross-functional drug development setting; collaborate with cell/molecular biologists to design gene-editing experiments and answer biological questions
• Author scientifically rigorous research reports to support IND and other regulatory filings
• Present scientific findings to a broad audience, including leadership, to help inform decision-making for therapeutic programs

Minimum Qualifications

• Ph.D. in computational biology, bioinformatics, genomics, computer science or a related field
• Demonstrated record of developing computational pipelines to analyze DNA high-throughput sequencing data and usage of common bioinformatics tools (e.g. bwa, BEDtools, GATK, IGV)
• Proficiency with Python is essential; familiarity with other languages such as C++, R, and MATLAB is also helpful
• Ability to work independently and successfully in a matrix environment, prioritize and manage multiple tasks simultaneously, integrate cross-functional issues and balance competing priorities effectively
• A high degree of energy, accuracy and attention to detail, and a passion for creating transformative gene-based medicines for patients with serious diseases

Preferred Qualifications

• At least 2 years of industry experience developing bioinformatics tools for gene editing
• Proficiency with application of NGS tools to characterize on-target, off-target, and translocation profiles of a gene editing process
• Demonstrated record of authoring research reports to support regulatory filings
• Familiarity with sequencing platforms (Illumina, 10x Genomics) and NGS library preparation methods
• Proficiency with statistical and/or machine learning methods
• Proficiency with handling large-scale genomic data in a Linux and/or cloud environment (e.g. AWS, DNAnexus)

Competencies

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.

CRISPR Therapeutics believes in fostering a dynamic workplace that balances remote work flexibility with the benefits of in-person interactions. Our employees work at least three days on-site, creating a collaborative work environment, where we cultivate mentorship opportunities, increase cross-functional communication and offer opportunities for our employees to connect.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

To view our Privacy Statement, please click the following link: http://www.crisprtx.com/about-us/privacy-policy

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