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Vp Clinical Operations Jobs (NOW HIRING)

Covenant Health

VP CLINICAL INFORMATICS

Knoxville, TN · On-site

Overview Vice President, Clinical Informatics, Ambulatory and Diagnostic Services Full Time, 80 ... operational needs of the organization. * Establishes the deliverables and projected milestones for ...

Covenant Health

VP CLINICAL INFORMATICS

Knoxville, TN · On-site

Vice President, Clinical Informatics, Ambulatory and Diagnostic Services Full Time, 80 Hours Per ... operational needs of the organization. * Establishes the deliverables and projected milestones for ...

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Vp Clinical Operations information

See salary details

$68.5K

$155.8K

$264K

How much do vp clinical operations jobs pay per year?

As of Sep 2, 2026, the average yearly pay for vp clinical operations in the United States is $155,780.00, according to ZipRecruiter salary data. Most workers in this role earn between $115,500.00 and $185,000.00 per year, depending on experience, location, and employer.

What does a VP of Clinical Operations do?

A Vice President (VP) of Clinical Operations oversees the planning, execution, and management of clinical trials and research activities within a healthcare or pharmaceutical organization. They are responsible for ensuring clinical operations are compliant with regulatory standards, meet organizational goals, and are completed on time and within budget. This role involves leading clinical teams, developing operational strategies, and collaborating with other departments to ensure the success of clinical programs. The VP of Clinical Operations also plays a key role in optimizing processes, managing resources, and maintaining quality in all phases of clinical research.

What are some of the key challenges a VP of Clinical Operations typically faces in scaling clinical trials across multiple sites?

A VP of Clinical Operations often encounters challenges such as maintaining consistent trial quality and regulatory compliance across diverse sites, managing communication among cross-functional teams, and ensuring that patient recruitment targets are met. Balancing operational efficiency with the need for rigorous data integrity is critical, as is adapting to rapidly evolving regulatory requirements. Successful leaders in this role proactively implement standardized processes, foster strong relationships with site staff, and leverage technology to streamline operations and enhance visibility across all trial locations.

What are the key skills and qualifications needed to thrive as a VP of Clinical Operations, and why are they important?

To thrive as a VP of Clinical Operations, you need extensive experience in healthcare management, clinical operations oversight, and a relevant advanced degree such as an MBA, MHA, or MSN. Familiarity with healthcare compliance systems, EMRs/EHRs, and quality improvement frameworks is crucial, and certifications like Lean Six Sigma or PMP are often valued. Exceptional leadership, strategic thinking, and communication skills are vital for driving organizational change and building effective cross-functional teams. These skills are essential for ensuring operational excellence, regulatory compliance, and high-quality patient care across clinical settings.

What is the difference between Vp Clinical Operations vs Clinical Operations Manager?

AspectVp Clinical OperationsClinical Operations Manager
ResponsibilitiesOversees multiple clinical departments, strategic planning, and high-level decision-makingManages daily clinical trial activities, team supervision, and project execution
Required CredentialsTypically requires advanced degrees (e.g., MD, PhD, or equivalent), extensive experience in clinical researchBachelor’s or Master’s degree in life sciences or related field, relevant experience in clinical trials
Work EnvironmentExecutive-level setting, collaborating with senior leadership and external partnersOperational setting, working closely with clinical teams and project staff

The Vp Clinical Operations focuses on strategic leadership and oversight of clinical programs, while the Clinical Operations Manager handles day-to-day trial management. Both roles require relevant experience, but the Vp role involves broader organizational responsibilities and higher-level decision-making.

More about Vp Clinical Operations jobs

What cities are hiring for Vp Clinical Operations jobs?

Cities with the most Vp Clinical Operations job openings:

What are the most commonly searched types of Clinical Operations jobs?

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Vp Clinical Operations jobs near you
Infographic showing various Vp Clinical Operations job openings in the United States as of August 2026, with employment types broken down into 84% Full Time, 13% Part Time, 1% Temporary, 1% Contract, and 1% Nights. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $155,780 per year, or $74.9 per hour.

Vice President, Clinical Development

Spyre Therapeutics

Remote

Full-time

Medical, Retirement, PTO

Re-posted 11 days ago

Job description

Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23, and IL-17A/F as well as rational combination programs.
Role Summary:
The Vice President, Clinical Development (Immunology & Inflammation), reporting to the SVP of IBD Clinical Development, will provide strategic and operational leadership across Spyre's clinical portfolio of antibody therapeutics for IBD. This role is uniquely designed for a physician leader who thrives in a high-growth biotechnology environment and enjoys balancing long-term clinical development strategy with hands-on execution. The successful candidate will personally lead the ongoing Phase 2 platform study while helping to shape the future registrational program.
Key Responsibilities:
  • Clinical Leadership:
    • Provide strategic leadership and medical expertise for the clinical development of our cutting-edge antibody portfolio in IBD.
    • Develop and continuously refine integrated clinical development plans aligned with corporate objectives, competitive landscape, and evolving scientific insights.
    • Serve as a hands-on study lead for the current platform trial as well as contribute to planning pivotal studies.
    • Personally contribute to protocol development, medical review, safety assessment, data interpretation, and study-level decision making for ongoing and future IBD clinical trials.
    • Support the efforts of the medical monitoring team which ensures timely responses to investigative sites, provides medical safety oversight, and supports the collection of high-quality, clinically robust data.
  • Program Strategy & Trial Execution:
    • Provide medical and scientific leadership for the design, conduct, analysis, and interpretation of clinical studies across all phases of development.
    • Lead protocol development, study conduct, data review, and interpretation for ongoing clinical trials, partnering closely with clinical operations, regulatory, biometrics, etc., to ensure successful execution.
    • Drive key development decisions through analysis of emerging clinical, translational, safety, and competitive data.
    • Chair or contribute to governance committees and cross-functional program teams.
  • Cross-functional Collaboration:
    • Partner closely with Regulatory Affairs, Biostatistics, Clinical Operations, Translational Sciences, Medical Affairs, CMC, Commercial, and Corporate Development teams to ensure coordinated execution of development strategies.
    • Promote a culture of scientific excellence, accountability, and collaboration.
  • Regulatory Interface:
    • Lead clinical and medical strategy for regulatory interactions globally.
    • Serve as a primary medical representative for regulatory submissions, including INDs, CTAs, briefing packages, BLAs, NDAs, and related responses.
    • Ensure development programs are conducted in compliance with global regulatory requirements and industry best practices.
  • Safety Oversight:
    • Provide ongoing medical oversight of participant safety and benefit-risk assessments across assigned programs.
    • Review and interpret emerging safety data and contribute to safety governance activities, including Data Monitoring Committees and internal safety review forums.
    • Support signal detection, risk management planning, and clinical risk mitigation strategies.
  • Leadership & Mentorship:
    • Lead and mentor a high-performing clinical development team as the company grows.
    • Contribute broadly to corporate strategy, organizational planning, and leadership initiatives.
    • Other duties as assigned.

Ideal Candidate:
  • MD or equivalent medical degree is required.
  • Minimum of 7+ years clinical development experience within the pharmaceutical or biotech industry, including substantial leadership experience in immunology, inflammation, or gastroenterology.
  • Training and/or experience in clinical development in gastroenterology or immunology & inflammation is strongly preferred.
  • Demonstrated success leading mid- and late-stage clinical development programs.
  • Experience developing antibody therapeutics.
  • Experience leading complex, adaptive, umbrella, basket, or platform clinical trials is highly desirable.
  • Deep expertise in inflammatory bowel disease and/or other immune-mediated inflammatory disorders strongly preferred.
  • Significant experience with global regulatory interactions and submissions, including INDs, CTAs, briefing documents for global regulatory agencies.
  • Strong understanding of clinical trial design, biostatistics, translational medicine, drug development, and global regulatory requirements.
  • Demonstrated ability to influence strategy and drive cross-functional decision-making in a matrixed environment.
  • Demonstrated willingness and ability to remain personally engaged in study-level execution while simultaneously providing strategic leadership.
  • Strategic, entrepreneurial leader with the ability to balance long-term vision and hands-on execution in a fast-paced biotech environment.

What We Offer:
  • Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
  • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
  • Unlimited PTO
  • Two, one-week company-wide shutdowns each
  • Commitment to provide professional development opportunities.
  • Remote working environment with frequent in-person meetings to address complex problems and build relationships.

The expected salary range offer for this role is $366,000 to $398,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.
As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.
Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain "@spyre.com." We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.
Please also be aware that all job postings will be listed on our website at spyre.com/careers/.

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