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Trial Master File Manager Jobs (NOW HIRING)

Karius

Clinical Trial Associate

Redwood City, CA · On-site +1

$41 - $56/hr

Reports to: Sr. Manager, Clinical Site Operations Location: Remote (Bay Area preferred) Primary ... Support the setup and maintenance of the Trial Master File (TMF) in accordance with sponsor SOPs ...

Karius

Clinical Trial Associate

Redwood City, CA · On-site +1

$41 - $56/hr

Reports to: Sr. Manager, Clinical Site Operations Location: Remote (Bay Area preferred) Primary ... Support the setup and maintenance of the Trial Master File (TMF) in accordance with sponsor SOPs ...

Olema Oncology

Senior Clinical Trial Associate

Boston, MA · On-site

$110K - $115K/yr

Manages study-related vendors and serves as a point of contact for contracted CROs, study staff ... Ensures receipt, completeness, accuracy, and appropriate filing (Trial Master File, study ...

Praxis Precision Medicines, Inc.

TMF Operations Lead

OR · On-site +1

$33.50 - $45.75/hr

As our Trial Master File expert, you'll partner with Clinical Operations and cross-functional teams ... Expert understanding of TMF structure, content, lifecycle management, quality controls, and ...

Clinovo

Clinical Trial Manager

Cambridge, MA · On-site

$175K/yr

The Clinical Trial Manager (CTM) plays a key role in the successful execution of clinical research ... Maintain complete, accurate, and inspection-ready Trial Master File (TMF) documentation. Study ...

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How much do trial master file manager jobs pay per year?

As of Sep 4, 2026, the average yearly pay for trial master file manager in the United States is $75,583.00, according to ZipRecruiter salary data. Most workers in this role earn between $55,500.00 and $93,500.00 per year, depending on experience, location, and employer.

What is a trial master file manager?

A Trial Master File Manager is a professional responsible for overseeing the creation, maintenance, and quality control of the Trial Master File (TMF) in clinical research. The TMF is a collection of essential documents that allow the conduct of a clinical trial to be reconstructed and evaluated. The manager ensures that all documents are complete, accurate, and compliant with regulatory requirements throughout the trial's lifecycle. They work closely with clinical teams, auditors, and regulatory authorities to guarantee readiness for inspections and audits. Their role is crucial for maintaining transparency and credibility in clinical research processes.

What are the key skills and qualifications needed to thrive as a trial master file manager?

To thrive as a Trial Master File Manager, you typically need a strong background in clinical research, regulatory requirements, and document management, often supported by a degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, GCP guidelines, and relevant industry certifications like DIA's TMF Professional Certification is important. Attention to detail, organizational skills, and effective communication help ensure TMF integrity and coordination across cross-functional teams. These skills are crucial for maintaining regulatory compliance, audit readiness, and efficient clinical trial operations.

What are some common challenges faced by trial master file managers, and how can they be addressed?

Trial Master File Managers often encounter challenges such as ensuring TMF completeness, maintaining regulatory compliance, and coordinating document submissions across multiple stakeholders. Keeping documents up-to-date and audit-ready requires strong attention to detail and effective communication with clinical teams, vendors, and sponsors. Leveraging electronic TMF systems, implementing standardized processes, and promoting regular training can help address these challenges and ensure the integrity of the TMF throughout a study.
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Trial Master File Manager jobs near you
Infographic showing various Trial Master File Manager job openings in the United States as of August 2026, with employment types broken down into 87% Full Time, 12% Part Time, and 1% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $75,583 per year, or $36.3 per hour.

Document Coordinator

Integrated Resources INC

Cambridge, MA • On-site

Contractor

Re-posted 19 days ago

Job description

Company Description

A Few Words About Us - Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing.

Job Description

Job Summary: 

The primary purpose of this job is to provide support for document approval/finalization and preparation for publishing; submission of documents to clinical study Trial Master File and QC of Trial Master File, including remediation 

Principal Accountabilities:

Assist Medical Writing Operations staff with document approval and notification processes and maintenance of the Trial Master File, including submission of documents and routine QC and remediation. 90% 

Assist Medical Writing staff with document formatting/troubleshooting/reference management. 10% 

Impacts quality of clinical documentation. Liaises with staff across Development Sciences and Global Medical. 

Knowledge & Skills: 

Advanced Microsoft Office skills (Word, PowerPoint, Excel); familiarity with Adobe, Documentum, other systems as needed. 

Strong attention to detail.

Ability to multitask in a fast-paced environment.

Excellent oral and written communication skills. 

Aptitude for learning new systems and technology.

Familiarity with the clinical development process, understanding of trial master file. 

Qualifications

Minimum Education Requirements: Associate's Degree required; Bachelor's Degree preferred.

Minimum Experience Requirements: 1+ year experience in biotech or pharmaceutical company (R&D, Clinical preferred).


Additional Information

With Regards,


Kavita Kumari

Clinical Recruiter

Integrated Resources, Inc

IT REHAB CLINICAL NURSING

Inc. 5000 - 2007-2014 (8th Year)

Certified MBE I GSA - Schedule 66 I GSA - Schedule 621I I GSA - Schedule 70

Tel: 732-549-2030 x208

Fax: 732-549-5549

Direct: 732-549-5302

www.irionline.com

https://www.linkedin.com/in/rkavita


Integrated Resources logo

About Integrated Resources

Sourced by ZipRecruiter

Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.

Industry

Recruiting and staffing services

Company size

51 - 200 Employees

Headquarters location

Edison, NJ, US

Year founded

1996

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