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Trial Master File Manager Jobs (NOW HIRING)

VENESCO, LLC

Clinical Trial Manager

Fort Detrick, MD

$125K - $143K/yr

Manage Trial Master File (TMF) documentation. * Coordinate study working groups and stakeholder meetings. * Ensure ClinicalTrials.gov registration and reporting requirements are met. * Monitor study ...

VENESCO LLC

Clinical Trial Manager

Frederick, MD · On-site

$125K - $143K/yr

Manage Trial Master File (TMF) documentation. * Coordinate study working groups and stakeholder meetings. * Ensure ClinicalTrials.gov registration and reporting requirements are met. * Monitor study ...

Cellectis

Clinical Trial Associate

Manhattan, NY

$36.75 - $50.25/hr

This role contributes to the maintenance of inspection-ready trial documentation and systems, including the Trial Master File (TMF/eTMF) and Clinical Trial Management System (CTMS), in compliance ...

Cellectis

Clinical Trial Associate

Manhattan, NY · On-site

$36.75 - $50.25/hr

This role contributes to the maintenance of inspection-ready trial documentation and systems, including the Trial Master File (TMF/eTMF) and Clinical Trial Management System (CTMS), in compliance ...

CTI

Clinical Trial Manager

Covington, KY · On-site +1

Manage clinical monitoring related project milestones and proactively address deficiencies ... Oversee the core clinical portions of the Trial Master File and ensure they are up-to-date and ...

CTI

Clinical Trial Manager

Covington, KY · Remote

Manage clinical monitoring related project milestones and proactively address deficiencies ... Oversee the core clinical portions of the Trial Master File and ensure they are up-to-date and ...

Attovia Therapeutics

Clinical Trials Associate

San Carlos, CA · On-site

$40.50 - $55.25/hr

Trial Master File (TMF) * Assist with the management and quality control of electronic Trial Master Files (eTMFs). * Review documents for completeness, accuracy, and TMF filing readiness. * Support ...

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How much do trial master file manager jobs pay per year?

As of Aug 21, 2026, the average yearly pay for trial master file manager in the United States is $75,583.00, according to ZipRecruiter salary data. Most workers in this role earn between $55,500.00 and $93,500.00 per year, depending on experience, location, and employer.

What is a trial master file manager?

A Trial Master File Manager is a professional responsible for overseeing the creation, maintenance, and quality control of the Trial Master File (TMF) in clinical research. The TMF is a collection of essential documents that allow the conduct of a clinical trial to be reconstructed and evaluated. The manager ensures that all documents are complete, accurate, and compliant with regulatory requirements throughout the trial's lifecycle. They work closely with clinical teams, auditors, and regulatory authorities to guarantee readiness for inspections and audits. Their role is crucial for maintaining transparency and credibility in clinical research processes.

What are the key skills and qualifications needed to thrive as a trial master file manager?

To thrive as a Trial Master File Manager, you typically need a strong background in clinical research, regulatory requirements, and document management, often supported by a degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, GCP guidelines, and relevant industry certifications like DIA's TMF Professional Certification is important. Attention to detail, organizational skills, and effective communication help ensure TMF integrity and coordination across cross-functional teams. These skills are crucial for maintaining regulatory compliance, audit readiness, and efficient clinical trial operations.

What are some common challenges faced by trial master file managers, and how can they be addressed?

Trial Master File Managers often encounter challenges such as ensuring TMF completeness, maintaining regulatory compliance, and coordinating document submissions across multiple stakeholders. Keeping documents up-to-date and audit-ready requires strong attention to detail and effective communication with clinical teams, vendors, and sponsors. Leveraging electronic TMF systems, implementing standardized processes, and promoting regular training can help address these challenges and ensure the integrity of the TMF throughout a study.
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Trial Master File Manager jobs near you
Infographic showing various Trial Master File Manager job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 11% Part Time, and 1% Contract. Highlights an 81% Physical, 2% Hybrid, and 17% Remote job distribution, with an average salary of $75,583 per year, or $36.3 per hour.

Clinical Trial Manager

VENESCO, LLC

Fort Detrick, MD

$125K - $143K/yr

Full-time

Posted 27 days ago

Job description

Description

Clinical Trial Manager  


Venesco LLC is seeking Clinical Trial Managers to provide leadership and operational oversight for FDA-regulated clinical studies, ensuring studies are executed in accordance with approved protocols, budgets, timelines, regulatory requirements, and quality standards.   

Requirements

Duties and Responsibilities 

  • Manage all phases of clinical trial startup, conduct, and closeout. 
  • Develop and maintain project plans and timelines. 
  • Coordinate protocol development and study documentation. 
  • Manage Trial Master File (TMF) documentation. 
  • Coordinate study working groups and stakeholder meetings. 
  • Ensure ClinicalTrials.gov registration and reporting requirements are met. 
  • Monitor study metrics and status reports. 
  • Coordinate interactions among sites, CROs, sponsors, and regulatory personnel. 
  • Identify operational risks and develop mitigation plans. 
  • Support FDA inspections and sponsor audits. 


Minimum Qualifications 

  • Bachelor's degree in Life Sciences or related field. 
  • Minimum 7 years of clinical trial management experience. 
  • Experience managing FDA-regulated studies. 
  • Strong understanding of ICH-GCP and FDA requirements. 


Venesco, LLC, is an equal opportunity and affirmative action employer. Venesco is committed to administering all employment and personnel actions on the basis of merit and free of discrimination based on race, ethnicity, religious affiliation, gender, gender identity or expression, sexual orientation, national origin, protected veteran status, or status as an individual with a disability. Consistent with this commitment, we are dedicated to the employment and advancement of qualified minorities, women, individuals with disabilities, protected veterans, persons of all ethnic backgrounds and religions according to their abilities.

For more information on Venesco, LLC., visit https://venesco.com.

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