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Trial Master File Manager Jobs in Missouri (NOW HIRING)

Jobgether

Ensure Trial Master Files remain inspection-ready and compliant with applicable regulations, procedures, and ALCOA principles. * Perform Records Management Compliance (RMC) oversight activities and ...

IQVIA

CRA 2, Oncology, IQVIA

Kansas City, MO · On-site

$87K - $145K/yr

Manage the progress of assigned studies by tracking regulatory submissions and approvals ... Ensure copies/originals (as required) site documents are available for filing in the Trial Master ...

IQVIA

CRA 2, Oncology, IQVIA

Kansas City, MO

$87K - $145K/yr

Manage the progress of assigned studies by tracking regulatory submissions and approvals ... Ensure copies/originals (as required) site documents are available for filing in the Trial Master ...

IQVIA

Sr. Clinical Research Associate, IQVIA

Kansas City, MO · On-site

$101K - $169K/yr

Perform monitoring and site management work to ensure that sites are conducting the study(ies) and ... Ensure copies/originals (as required) site documents are available for filing in the Trial Master ...

IQVIA

Sr. Clinical Research Associate, IQVIA

Kansas City, MO · On-site

$101K - $169K/yr

Perform monitoring and site management work to ensure that sites are conducting the study(ies) and ... Ensure copies/originals (as required) site documents are available for filing in the Trial Master ...

IQVIA

CRA 1, IQVIA Biotech

Kansas City, MO · On-site

$71K - $145K/yr

... site management activities. In this position, you will ensure that assigned study sites conduct ... the Trial Master File (TMF) and the Investigator Site File (ISF). A central part of this role ...

Morgan & Morgan, P.A.

Trial Attorney

Saint Louis, MO

Our attorneys are privy to world-class case docket management software, litigation resources, and a ... Drafting and filing of litigation documents to include pleadings, discovery requests, discovery ...

Morgan & Morgan, P.A.

Trial Attorney

Saint Louis, MO

Our attorneys are privy to world-class case docket management software, litigation resources, and a ... Drafting and filing of litigation documents to include pleadings, discovery requests, discovery ...

Morgan & Morgan, P.A.

Trial Attorney

Saint Louis, MO · On-site

Our attorneys are privy to world-class case docket management software, litigation resources, and a ... Drafting and filing of litigation documents to include pleadings, discovery requests, discovery ...

Morgan & Morgan, P.A.

Trial Attorney

Saint Louis, MO · On-site

Drafting and filing of litigation documents to include pleadings, discovery requests, discovery ... Ability to manage high volume of litigation cases * Excellent client service and communication ...

Robert Half

Litigation Paralegal

Chesterfield, MO · On-site

$45K - $60K/yr

Familiarity with trial preparation, including exhibit assembly, file management, and deadline coordination. * Proficiency with case management software and standard legal document systems. * Strong ...

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All JobsTrial Master File JobsTrial Master File Manager JobsTrial Master File Manager Jobs in Missouri

Trial Master File Manager information

See Missouri salary details

$41.7K

$70.9K

$106.9K

How much do trial master file manager jobs pay per year?

As of Aug 1, 2026, the average yearly pay for trial master file manager in Missouri is $70,898.00, according to ZipRecruiter salary data. Most workers in this role earn between $52,100.00 and $87,700.00 per year, depending on experience, location, and employer.

What are some common challenges faced by Trial Master File Managers, and how can they be addressed?

Trial Master File Managers often encounter challenges such as ensuring TMF completeness, maintaining regulatory compliance, and coordinating document submissions across multiple stakeholders. Keeping documents up-to-date and audit-ready requires strong attention to detail and effective communication with clinical teams, vendors, and sponsors. Leveraging electronic TMF systems, implementing standardized processes, and promoting regular training can help address these challenges and ensure the integrity of the TMF throughout a study.

What is a Trial Master File Manager?

A Trial Master File Manager is a professional responsible for overseeing the creation, maintenance, and quality control of the Trial Master File (TMF) in clinical research. The TMF is a collection of essential documents that allow the conduct of a clinical trial to be reconstructed and evaluated. The manager ensures that all documents are complete, accurate, and compliant with regulatory requirements throughout the trial's lifecycle. They work closely with clinical teams, auditors, and regulatory authorities to guarantee readiness for inspections and audits. Their role is crucial for maintaining transparency and credibility in clinical research processes.

What are the key skills and qualifications needed to thrive as a Trial Master File Manager, and why are they important?

To thrive as a Trial Master File Manager, you typically need a strong background in clinical research, regulatory requirements, and document management, often supported by a degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, GCP guidelines, and relevant industry certifications like DIA's TMF Professional Certification is important. Attention to detail, organizational skills, and effective communication help ensure TMF integrity and coordination across cross-functional teams. These skills are crucial for maintaining regulatory compliance, audit readiness, and efficient clinical trial operations.
What are the most commonly searched types of Trial Master File jobs in Missouri? The most popular types of Trial Master File jobs in Missouri are:
What are popular job titles related to Trial Master File Manager jobs in Missouri? For Trial Master File Manager jobs in Missouri, the most frequently searched job titles are:
What job categories do people searching Trial Master File Manager jobs in Missouri look for? The top searched job categories for Trial Master File Manager jobs in Missouri are:
What cities in Missouri are hiring for Trial Master File Manager jobs? Cities in Missouri with the most Trial Master File Manager job openings:
Trial Master File Manager jobs near you
Infographic showing various Trial Master File Manager job openings in Missouri as of June 2026, with employment types broken down into 96% Full Time, and 4% Part Time. Highlights an 77% Physical, 5% Hybrid, and 18% Remote job distribution, with an average salary of $70,898 per year, or $34.1 per hour.

TMF Team Lead

Jobgether

On-site, Remote

Other

Posted 9 days ago

Job description

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a TMF Team Lead based in Netherlands.

This role offers the opportunity to lead critical Trial Master File operations within a global clinical research environment.
You will ensure inspection readiness, compliance, and high-quality document management across multiple clinical studies.
The position combines operational leadership, quality oversight, and collaboration with international project teams and stakeholders.
You will play a key role in maintaining regulatory standards while improving processes and supporting successful clinical trial delivery.
Working with multidisciplinary teams, you will use data-driven insights and strong organizational skills to manage complex documentation activities.
This is an impactful opportunity for a detail-oriented professional who wants to contribute to advancing healthcare and improving patient outcomes.

Accountabilities:

The TMF Team Lead will oversee Trial Master File operations, ensuring compliance with regulatory requirements, internal procedures, and industry best practices. This role requires strong leadership, analytical thinking, and the ability to collaborate with global teams to maintain document quality and inspection readiness.

  • Lead and support the delivery of TMF services across multiple clinical studies.
  • Ensure Trial Master Files remain inspection-ready and compliant with applicable regulations, procedures, and ALCOA principles.
  • Perform Records Management Compliance (RMC) oversight activities and monitor documentation quality.
  • Track key performance indicators and communicate performance insights to project teams and external stakeholders.
  • Identify operational risks, develop mitigation strategies, and support continuous improvement initiatives.
  • Analyze TMF data and apply insights to drive informed, data-based decisions.
  • Develop and maintain project-specific Quality Management Documents.
  • Provide guidance and expertise on TMF-related topics to project team members.
  • Mentor, support, and develop team members while promoting a collaborative working environment.
  • Collaborate with internal teams, sponsors, external partners, and quality assurance stakeholders.
Requirements:

The ideal candidate has experience in clinical research operations, strong knowledge of regulatory requirements, and the ability to manage complex documentation processes in a highly regulated environment. You should be analytical, organized, and comfortable leading teams while working with global stakeholders.

  • University degree preferred, ideally in Life Sciences or a related field.
  • 3-5 years of relevant experience combining education and professional background.
  • Strong understanding of ICH Good Clinical Practice (GCP) guidelines.
  • Experience supporting regulatory inspections, including FDA, PMDA, EMA, BfArM, MHRA, or similar authorities.
  • Hands-on experience with document management systems and/or electronic Trial Master File (eTMF) solutions such as Veeva, Trial Interactive, or Documentum.
  • Experience working within regulated industries, preferably clinical research or pharmaceuticals.
  • Strong analytical skills with the ability to evaluate complex situations using multiple sources of information.
  • Excellent interpersonal and communication skills in a fast-paced, changing environment.
  • Ability to manage multiple priorities while maintaining accuracy and attention to detail.
  • Experience mentoring, training, or managing team members is highly valued.
Benefits:
  • Opportunity to contribute to meaningful healthcare projects that improve patient outcomes.
  • Global and collaborative work environment with multidisciplinary teams.
  • Remote work flexibility.
  • Supportive culture focused on inclusion, collaboration, and professional growth.
  • Career development opportunities and access to learning resources.
  • Exposure to international clinical research projects and industry-leading practices.
  • Opportunity to work with experienced professionals across global teams.
How Jobgether works:
We use an AI-powered matching process to ensure your application is reviewed quickly, objectively, and fairly against the role's core requirements. Our system identifies the top-fitting candidates, and this shortlist is then shared directly with the hiring company. The final decision and next steps (interviews, assessments) are managed by their internal team.
We appreciate your interest and wish you the best!
 Why Apply Through Jobgether? 
 
Data Privacy Notice: By submitting your application, you acknowledge that Jobgether will process your personal data to evaluate your candidacy and share relevant information with the hiring employer. This processing is based on legitimate interest and pre-contractual measures under applicable data protection laws (including GDPR). You may exercise your rights (access, rectification, erasure, objection) at any time.
 
 
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We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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