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Trial Master File Manager Jobs (NOW HIRING)

Medpace, Inc.

Trial Master File Specialist

Cincinnati, OH · On-site

$32.25 - $44/hr

The Trial Master File (TMF) is a collection of documents that stores all data and research ... It is an integral tool and helps teams manage trials more effectively. TMF oversight is important ...

GQR

Associate Director Trial Master File

Santa Rosa, CA

$36.75 - $50/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

San Francisco, CA

$39.50 - $54/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

Sonoma, CA

$37.50 - $51.25/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

San Jose, CA

$39.25 - $53.50/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

Sunnyvale, CA

$39.75 - $54.50/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

Hayward, CA

$38.50 - $52.50/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

Alameda, CA

$38.75 - $53/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

Santa Clara, CA

$39 - $53.25/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

Fremont, CA

$36.75 - $50/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

Mundelein, IL

$34.25 - $46.75/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

GQR

Associate Director Trial Master File

San Mateo, CA

$38.25 - $52/hr

Associate Director, Trial Master File (TMF) Position Summary The Associate Director, Trial Master ... Drive risk-based TMF oversight, issue management, and CAPA development related to TMF quality or ...

Medpace, Inc.

Trial Master File Specialist

Cincinnati, OH

$32.25 - $44/hr

The Trial Master File (TMF) is a collection of documents that stores all data and research ... It is an integral tool and helps teams manage trials more effectively. TMF oversight is important ...

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Trial Master File Manager information

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$44.5K

$75.6K

$114K

How much do trial master file manager jobs pay per year?

As of Jun 20, 2026, the average yearly pay for trial master file manager in the United States is $75,583.00, according to ZipRecruiter salary data. Most workers in this role earn between $55,500.00 and $93,500.00 per year, depending on experience, location, and employer.

What are some common challenges faced by Trial Master File Managers, and how can they be addressed?

Trial Master File Managers often encounter challenges such as ensuring TMF completeness, maintaining regulatory compliance, and coordinating document submissions across multiple stakeholders. Keeping documents up-to-date and audit-ready requires strong attention to detail and effective communication with clinical teams, vendors, and sponsors. Leveraging electronic TMF systems, implementing standardized processes, and promoting regular training can help address these challenges and ensure the integrity of the TMF throughout a study.

What is a Trial Master File Manager?

A Trial Master File Manager is a professional responsible for overseeing the creation, maintenance, and quality control of the Trial Master File (TMF) in clinical research. The TMF is a collection of essential documents that allow the conduct of a clinical trial to be reconstructed and evaluated. The manager ensures that all documents are complete, accurate, and compliant with regulatory requirements throughout the trial's lifecycle. They work closely with clinical teams, auditors, and regulatory authorities to guarantee readiness for inspections and audits. Their role is crucial for maintaining transparency and credibility in clinical research processes.

What are the key skills and qualifications needed to thrive as a Trial Master File Manager, and why are they important?

To thrive as a Trial Master File Manager, you typically need a strong background in clinical research, regulatory requirements, and document management, often supported by a degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, GCP guidelines, and relevant industry certifications like DIA's TMF Professional Certification is important. Attention to detail, organizational skills, and effective communication help ensure TMF integrity and coordination across cross-functional teams. These skills are crucial for maintaining regulatory compliance, audit readiness, and efficient clinical trial operations.
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Trial Master File Manager jobs near you
Infographic showing various Trial Master File Manager job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 100% Remote job distribution, with an average salary of $75,583 per year, or $36.3 per hour.
Trial Master File Specialist

Trial Master File Specialist

Medpace, Inc.

Cincinnati, OH • On-site

$32.25 - $44/hr

Other

Medical, PTO

Posted 23 days ago

Medpace rating

8.4

Company rating: 8.4 out of 10

Based on 8 frontline employees who took The Breakroom Quiz

15th of 57 rated research

Job description

Job Summary
We are currently hiring individuals seeking an exciting career in clinical research, managing our Trial Master File. The Trial Master File (TMF) is a collection of documents that stores all data and research collected on a given trial. The TMF allows us to conduct a clinical trial and ensures data integrity. It is an integral tool and helps teams manage trials more effectively. TMF oversight is important to the successful execution of a trial and ultimately plays a big role in a new drug or device receiving approval by the FDA. In this position, you will be working with a highly experienced team of administrators, specialists, and clinical research professionals that can help you grow your skillset while working for a growing and developing company. *This position is office-based in Cincinnati, OH.
Responsibilities
  • Provide guidance and support to study team members and sponsors regarding TMF management;
  • Initiate and manage TMF Specifications based on scope of work, protocol, and other core documents working with functional area leads and sponsor contacts;
  • Set up and maintain study specific TMF folder structure;
  • Support CTMs with review of TMF Plans as required;
  • Support study team(s) during periodic TMF QCs by assisting with report development and metric reporting;
  • Report on TMF Health to Sponsors and CTMs;
  • Contribute to audit/inspection readiness activities by reviewing the TMF, TMF Specifications, and TMF Plans for accuracy, consistency, and completeness;
  • Train and mentor other TMF staff; and
  • help with other project and responsibilities, as assigned.

Qualifications
  • Bachelor's degree, life science field preferred
  • Proficient knowledge of Microsoft® Office and Adobe Acrobat®
  • Computer literacy (i.e., ability to file, scan, create folders, and organize files using various
  • software);
  • Ability to accurately and carefully follow procedures for completing work tasks; and
  • Ability to perform repetitive work without losing effectiveness/accuracy.

Medpace Overview
Medpace is a full-service clinical contract research organization (CRO). We provide Phase I-IV clinical development services to the biotechnology, pharmaceutical and medical device industries. Our mission is to accelerate the global development of safe and effective medical therapeutics through its scientific and disciplined approach. We leverage local regulatory and therapeutic expertise across all major areas including oncology, cardiology, metabolic disease, endocrinology, central nervous system, anti-viral and anti-infective. Headquartered in Cincinnati, Ohio, employing more than 6,000 people across 40+ countries.
Why Medpace?
People. Purpose. Passion. Make a Difference Tomorrow. Join Us Today.
The work we've done over the past 30+ years has positively impacted the lives of countless patients and families who face hundreds of diseases across all key therapeutic areas. The work we do today will improve the lives of people living with illness and disease in the future.
Cincinnati Perks
  • Cincinnati Campus Overview
  • Flexible work environment
  • Competitive PTO packages, starting at 20+ days
  • Competitive compensation and benefits package
  • Company-sponsored employee appreciation events
  • Employee health and wellness initiatives
  • Community involvement with local nonprofit organizations
  • Discounts on local sports games, fitness gyms and attractions
  • Modern, ecofriendly campus with an on-site fitness center
  • Structured career paths with opportunities for professional growth
  • Discounted tuition for UC online programs

Awards
  • Named a Top Workplace in 2024 by The Cincinnati Enquirer
  • Recognized by Forbes as one of America's Most Successful Midsize Companies in 2021, 2022, 2023 and 2024
  • Continually recognized with CRO Leadership Awards from Life Science Leader magazine based on expertise, quality, capabilities, reliability, and compatibility

What to Expect Next
A Medpace team member will review your qualifications and, if interested, you will be contacted with details for next steps.
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About Medpace

Sourced by ZipRecruiter

Medpace is a globally recognized clinicial contract research organization (CRO) based in Cincinnati, OH, in the United States. Established in 1992, it operates in the healthcare sector, providing scientifically-driven outsourcing solutions for the development of drugs and medical devices. It offers comprehensive services like full-service clinical development services, regulatory affairs management, clinical pharmacology, data management, statistical analysis, and medical writing. By applying a scientifically-driven, therapeutically-focused, and patient-centric approach, Medpace's mission is to accelerate the global development of safe and effective medical therapies.

Industry

Medical equipment and supplies manufacturing

Company size

1,001 - 5,000 Employees

Headquarters location

Cincinnati, OH, US

Year founded

1992

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