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Trial Master File Manager Jobs (NOW HIRING)

Jobgether

$25.75 - $35.25/hr

Process, review, classify, and resolve rejected Trial Master File documents across complex clinical studies and sponsor portfolios. * Manage essential documents in both electronic and hard-copy ...

Attovia Therapeutics

Clinical Trials Associate

San Carlos, CA · On-site

$40.50 - $55.25/hr

Trial Master File (TMF) * Assist with the management and quality control of electronic Trial Master Files (eTMFs). * Review documents for completeness, accuracy, and TMF filing readiness. * Support ...

Praxis Precision Medicines, Inc.

TMF Operations Lead

OR · On-site +1

$33.50 - $45.75/hr

As our Trial Master File expert, you'll partner with Clinical Operations and cross-functional teams ... Expert understanding of TMF structure, content, lifecycle management, quality controls, and ...

Clinovo

Clinical Trial Manager

Cambridge, MA · On-site

$175K/yr

The Clinical Trial Manager (CTM) plays a key role in the successful execution of clinical research ... Maintain complete, accurate, and inspection-ready Trial Master File (TMF) documentation. Study ...

Verastem

Clinical Trial Associate

Boston, MA · On-site

$36.50 - $49.75/hr

Manages trial related documents in the Veeva Vault Trial Master File (TMF); manages user access and facilitate training for internal/external users as needed; trains new users.

Vanguard Clinical

Clinical Operations Associate (Pool)

CA · Remote

$70K - $80K/yr

We are experts in clinical trial operations with a focus on Clinical Trial Management, CRO/Vendor Oversight, Trial Master File Management, Clinical Monitoring, Quality Assurance, Data Management and ...

Allen Spolden

Clinical Trial Associate

Manhattan, NY · Remote

$55K - $65K/yr

Strong organizational and time management skills. * Excellent written and verbal communication ... Maintain and organize Trial Master File (TMF) documentation. * Assist with regulatory document ...

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$44.5K

$75.6K

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How much do trial master file manager jobs pay per year?

As of Aug 21, 2026, the average yearly pay for trial master file manager in the United States is $75,583.00, according to ZipRecruiter salary data. Most workers in this role earn between $55,500.00 and $93,500.00 per year, depending on experience, location, and employer.

What is a trial master file manager?

A Trial Master File Manager is a professional responsible for overseeing the creation, maintenance, and quality control of the Trial Master File (TMF) in clinical research. The TMF is a collection of essential documents that allow the conduct of a clinical trial to be reconstructed and evaluated. The manager ensures that all documents are complete, accurate, and compliant with regulatory requirements throughout the trial's lifecycle. They work closely with clinical teams, auditors, and regulatory authorities to guarantee readiness for inspections and audits. Their role is crucial for maintaining transparency and credibility in clinical research processes.

What are the key skills and qualifications needed to thrive as a trial master file manager?

To thrive as a Trial Master File Manager, you typically need a strong background in clinical research, regulatory requirements, and document management, often supported by a degree in life sciences or a related field. Familiarity with electronic Trial Master File (eTMF) systems, GCP guidelines, and relevant industry certifications like DIA's TMF Professional Certification is important. Attention to detail, organizational skills, and effective communication help ensure TMF integrity and coordination across cross-functional teams. These skills are crucial for maintaining regulatory compliance, audit readiness, and efficient clinical trial operations.

What are some common challenges faced by trial master file managers, and how can they be addressed?

Trial Master File Managers often encounter challenges such as ensuring TMF completeness, maintaining regulatory compliance, and coordinating document submissions across multiple stakeholders. Keeping documents up-to-date and audit-ready requires strong attention to detail and effective communication with clinical teams, vendors, and sponsors. Leveraging electronic TMF systems, implementing standardized processes, and promoting regular training can help address these challenges and ensure the integrity of the TMF throughout a study.
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Trial Master File Manager jobs near you
Infographic showing various Trial Master File Manager job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 11% Part Time, and 1% Contract. Highlights an 81% Physical, 2% Hybrid, and 17% Remote job distribution, with an average salary of $75,583 per year, or $36.3 per hour.

Associate II, TMF Operations

Jobgether

On-site

$25.75 - $35.25/hr

Full-time

Posted 12 days ago

Job description

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Associate II, TMF Operations based in Netherlands.

This role supports the accurate and compliant management of essential clinical trial documentation within a global Clinical Research Organization (CRO) environment.
You will help ensure Trial Master File (TMF) records are processed, reviewed, maintained, and archived according to established procedures and regulatory expectations.
The position combines document quality control, records management, and collaboration with international clinical project teams.
You will contribute directly to data integrity and inspection readiness across complex studies and sponsor portfolios.
The role offers exposure to electronic TMF and document management systems while developing your understanding of clinical research operations.
Success requires strong attention to detail, organization, and the ability to manage multiple deadline-driven activities with accuracy.
It is an excellent opportunity for an early-career professional seeking to build expertise in clinical documentation and TMF operations.

Accountabilities
  • Perform TMF Approver and/or TMF QC Reviewer activities in accordance with applicable Standard Operating Procedures (SOPs) and established working practices.
  • Process, review, classify, and resolve rejected Trial Master File documents across complex clinical studies and sponsor portfolios.
  • Manage essential documents in both electronic and hard-copy formats while maintaining accurate records and consistent document standards.
  • Prepare periodic TMF Quality Control checklists and coordinate their review with relevant project team members.
  • Conduct periodic TMF quality control activities to verify compliance with regulatory requirements, ICH GCP principles, sponsor expectations, SOPs, and industry best practices.
  • Work with electronic document management repositories and eTMF systems to review, index, process, and maintain essential clinical trial documentation.
  • Apply standardized document naming conventions and indexing requirements to ensure records are complete, accurate, searchable, and inspection-ready.
  • Collaborate regularly with project teams and colleagues across functions and geographies to resolve documentation issues and support efficient TMF processes.
  • Maintain high standards of accuracy while managing multiple detailed activities within established timelines.
Requirements:
  • University degree preferred, ideally in Life Sciences or a related discipline.
  • Up to 1-2 years of relevant experience in TMF operations, records management, clinical research, CRO, pharmaceutical, or a related environment.
  • General understanding of clinical research principles, clinical trial processes, and the purpose of Trial Master Files.
  • Experience or demonstrated ability in data collection, indexing, document editing, and applying standardized naming conventions.
  • Ability to work effectively with electronic document repositories, eTMF platforms, or similar document management systems, with willingness to develop further technical proficiency.
  • Strong written and verbal communication skills, with the ability to present information clearly, accurately, and concisely.
  • Exceptional attention to detail and accuracy when handling highly structured and sensitive documentation.
  • Strong planning, prioritization, and organizational skills, with the ability to manage multiple tasks in a deadline-driven environment.
  • Proficiency with Microsoft Word and Excel.
  • Strong interpersonal and collaboration skills, with the ability to work effectively in a fast-paced, changing, and globally distributed environment.
  • A proactive, reliable, and quality-focused approach to work, with a commitment to following procedures and maintaining compliance.
Benefits:
  • Opportunity to build specialized experience in TMF operations and clinical research within a global CRO environment.
  • Exposure to international clinical studies, sponsor portfolios, project teams, and industry best practices.
  • Hands-on experience with electronic TMF and document management technologies.
  • Opportunities to collaborate with experienced professionals across clinical research and project teams.
  • A supportive and inclusive working environment that values collaboration, creativity, and professional development.
  • Career development opportunities within a global organization focused on improving clinical research and patient outcomes.
  • An environment committed to equal opportunity, diversity, inclusion, and respectful collaboration.
  • Meaningful work contributing to the quality, compliance, and integrity of clinical trials that can ultimately improve patients' lives.
How Jobgether works:
We use an AI-powered matching process to ensure your application is reviewed quickly, objectively, and fairly against the role's core requirements. Our system identifies the top-fitting candidates, and this shortlist is then shared directly with the hiring company. The final decision and next steps (interviews, assessments) are managed by their internal team.
We appreciate your interest and wish you the best!
 Why Apply Through Jobgether? 
 
Data Privacy Notice: By submitting your application, you acknowledge that Jobgether will process your personal data to evaluate your candidacy and share relevant information with the hiring employer. This processing is based on legitimate interest and pre-contractual measures under applicable data protection laws (including GDPR). You may exercise your rights (access, rectification, erasure, objection) at any time.
 
 
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We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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