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Senior Cra Jobs in Raleigh, NC (NOW HIRING)

Veranex

Sr Clinical Research Associate

Raleigh, NC · On-site

$98K - $140K/yr

The Sr. CRA will participate in the planning, development, and execution of clinical trials to evaluate the safety, effectiveness and performance of medical devices. Under management supervision, the ...

Parexel

Senior Clinical Research Associate

Raleigh, NC · On-site

Parexel International LLC Position Title: Sr. Clinical Research Associate *Multiple Openings ... Serving as a Lead Clinical Research Associate (CRA) for clinical studies; Clinical Trial Management ...

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Senior Cra information

See Raleigh, NC salary details

$35K

$91.7K

$139.5K

How much do senior cra jobs pay per year?

As of Aug 13, 2026, the average yearly pay for senior cra in Raleigh, NC is $91,676.00, according to ZipRecruiter salary data. Most workers in this role earn between $60,800.00 and $124,400.00 per year, depending on experience, location, and employer.

Is it hard to get a senior CRA job?

Securing a senior Clinical Research Associate (CRA) position can be competitive, often requiring several years of experience in clinical trials, strong knowledge of Good Clinical Practice (GCP), and relevant certifications. Candidates with a proven track record in monitoring, regulatory compliance, and familiarity with clinical trial management systems tend to have better prospects.

How does a senior clinical research associate (CRA) typically collaborate with site staff and project teams during a clinical trial?

A Senior CRA regularly works with site staff, including investigators and coordinators, to ensure clinical trials are conducted according to protocol, regulatory requirements, and Good Clinical Practice (GCP) guidelines. They serve as a key liaison, communicating study updates, addressing site concerns, and providing training when needed. Additionally, Senior CRAs often collaborate with project managers, data managers, and other CRAs to monitor progress, resolve issues, and ensure data integrity. This teamwork is critical for maintaining study timelines and overall trial quality.

What is the difference between Senior Cra vs Clinical Research Associate?

AspectSenior CraClinical Research Associate
Required CredentialsBachelor's degree, experience in clinical trials, often some certificationsBachelor's degree, entry-level to mid-level experience, some certifications
Work EnvironmentLeads monitoring activities, manages sites, mentors junior staffPerforms site monitoring, data collection, and compliance checks
Employer & Industry UsagePharmaceutical companies, CROs, biotech firmsPharmaceutical companies, CROs, biotech firms

The main difference between a Senior Cra and a Clinical Research Associate is experience level and responsibilities. Senior Cras typically oversee monitoring activities, mentor junior staff, and handle more complex tasks, while Clinical Research Associates focus on site monitoring and data collection. Both roles are essential in clinical trials and share similar industry environments and credentials.

What are the key skills and qualifications needed to thrive as a senior clinical research associate (CRA), and why are they important?

To thrive as a Senior Clinical Research Associate, you need deep knowledge of clinical trial protocols, regulatory guidelines (such as GCP), and several years of hands-on experience in clinical monitoring. Familiarity with electronic data capture (EDC) systems, CTMS platforms, and certifications like ACRP or SOCRA are commonly required. Excellent organizational skills, attention to detail, and effective communication are soft skills that set top candidates apart. These skills ensure trial integrity, regulatory compliance, and smooth collaboration among sponsors, sites, and teams.

What is a senior clinical research associate (CRA)?

Senior Clinical Research Associates (Senior CRAs) are experienced professionals responsible for overseeing and monitoring clinical trials to ensure compliance with regulatory guidelines, protocols, and good clinical practice. They play a key role in managing study sites, reviewing data, and ensuring the integrity and quality of clinical research. Senior CRAs also mentor junior staff, resolve complex issues, and maintain effective communication between sponsors, sites, and regulatory bodies. Their expertise helps ensure that clinical trials are conducted safely and efficiently.

What does a senior clinical research associate do?

A senior clinical research associate (CRA) oversees and monitors clinical trials to ensure compliance with protocols, Good Clinical Practice (GCP), and regulatory requirements. They coordinate with study sites, review data quality, and may mentor junior staff, often using electronic data capture systems and requiring relevant certifications like a CRA certification. Their role is essential in ensuring the integrity and accuracy of clinical trial data.

What are the most commonly searched types of Cra jobs in Raleigh, NC?

The most popular types of Cra jobs in Raleigh, NC are:

What are popular job titles related to Senior Cra jobs in Raleigh, NC?

For Senior Cra jobs in Raleigh, NC, the most frequently searched job titles are:

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The top searched job categories for Senior Cra jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Senior Cra jobs?

Cities near Raleigh, NC with the most Senior Cra job openings:

Senior Cra jobs near you
Infographic showing various Senior Cra job openings in Raleigh, NC as of August 2026, with employment types broken down into 100% Full Time. Highlights an 47% In-person, 15% Hybrid, and 38% Remote job distribution, with an average salary of $91,676 per year, or $44.1 per hour.

Clinical Research Associate II/III - US

Optimapharm d.o.o.

Raleigh, NC • On-site, Remote

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 5 days ago

Job description

Location: Remote
Who we are?
Optimapharm is a mid-sized, global Contract Research Organisation (CRO) turning science into hope through agile, patient-focused clinical development. We specialise in Phase I-IV clinical studies, delivering Full-Service and Functional Service Provision (FSP) solutions that help sponsors move faster and execute with confidence.
With operations in 40+ countries and 2x the patient reach of the average mid-sized CRO, we enable accelerated regulatory pathways, faster study start-up, and access to diverse patient populations worldwide. At Optimapharm, you'll contribute to meaningful clinical research while growing your career in a dynamic, people‑focused, global environment.
As we expand our US Clinical Operations team, we're searching for a CRA II/III who is motivated by quality, driven by purpose, and eager to contribute to innovative clinical research that changes lives.
Joining Optimapharm means more than taking on your next role - it's an opportunity to build a long-term career with a global CRO that values growth, development, and excellence. Our structured career pathway provides clear progression and recognition of your expertise: CRA I → CRA II → CRA III → Senior CRA.
Here, your dedication is rewarded with meaningful growth opportunities, exposure to diverse studies, and the support needed to reach your full potential.
What do we offer?
  • Working in a successful company that's growing and developing every day
  • Being part of a clinical research team that transforms science into hope for patients
  • International projects and professional growth
  • Company that supports life balance
  • Company with healthy culture
  • Working with a highly experienced team of clinical research professionals
  • Competitive salary
  • Competitive PTO entitlement
  • Health insurance, including vision and dental plans, to meet your and your family's needs
  • Comprehensive pension plan to maximize savings and prepare confidently for the future
  • Employee engagement programs
  • Well-being initiatives
  • Training and development program
  • Fast-paced career path progression

Who are we looking for?
Qualifications and Experience
  • University degree, preferably in medical or life sciences; nursing education or other relevant healthcare college degree
  • At least 2 years of independent clinical trial monitoring experience
  • High level of knowledge of ICH GCP Guidelines, knowledge of regulatory requirements and a strong interest in clinical research
  • Computer proficiency is mandatory
  • Ability to read, analyze, and interpret common scientific and technical journals
  • Excellent verbal and written communication skills
  • Very good interpersonal and negotiation skills
  • Ability to work independently, pro-active
  • Affinity to work effectively and efficiently in a matrix environment
  • A current, valid driver's license

Your responsibilities
  • Perform routine site visits independently, including pre-study, initiation, interim monitoring and closeout visits
  • Manage assigned sites by regular contact with site personnel to ensure site compliance, adequate enrolment and understanding of study requirements
  • Independently perform CRF review; query generation and resolution against established data review guidelines or data management systems as applicable
  • Identifying and escalating potential risks and identifying retraining opportunities for site personnel
  • Preparation of corrective and preventive (CAPA) plans for issues identified during monitoring activities and pro-active follow of each, individual CAPA until timely resolution
  • Preparation of documents required for EC submissions and notifications, translation of study-related documents (where applicable), and other tasks as instructed by the supervisor
  • Independently negotiate study budgets with potential investigators/institutions and assist with the execution of site contracts as applicable
  • Administration of site payments in accordance with relevant project instructions

By joining our fast-growing and prosperous team, you will have an excellent opportunity for further personal growth and career development.
If you would be interested in joining the Optimapharm team, please send your CV and note that only shortlisted candidates who meet the requirements will be contacted for the further selection process.
Compensation is competitive and final offers will reflect each candidate's experience, skills, and qualifications.
Disclaimer: Unsolicited CVs sent to Optimapharm (Talent Acquisition Team, Hiring Managers or any other OPT employee) by recruitment agencies will not be considered for this role. Optimapharm follows a direct sourcing strategy and collaborates exclusively with selected recruitment partners when external support is required.

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