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Senior Bioinformatics Software Engineer Jobs (NOW HIRING)

Sr HPC Engineer

Houston, TX · On-site

$96K - $132K/yr

JOB SUMMARY We are seeking a Senior HPC Engineer with deep hands-on experience in high-performance ... of bioinformatics software and workflows. • Implement monitoring and operational best practices ...

Overview Black Canyon Consulting (BCC) is searching for a Software Developer in Bioinformatics and Big Data to support our work at the National Institutes of Health. This opportunity is full time and ...

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Senior Bioinformatics Software Engineer information

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$84.5K

$102.3K

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How much do senior bioinformatics software engineer jobs pay per year?

As of Jun 7, 2026, the average yearly pay for senior bioinformatics software engineer in the United States is $102,271.00, according to ZipRecruiter salary data. Most workers in this role earn between $94,500.00 and $110,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Bioinformatics Software Engineer, and why are they important?

To thrive as a Senior Bioinformatics Software Engineer, you need a strong background in computer science, biology, and data analysis, often supported by an advanced degree in bioinformatics or a related field. Expertise with programming languages (such as Python, R, or Java), cloud computing, bioinformatics tools, and version control systems is typically required, along with experience using databases and relevant software frameworks. Strong problem-solving skills, collaboration, and effective communication are crucial soft skills for working with multidisciplinary teams and presenting complex data. These combined skills enable the effective development and maintenance of robust software tools that support cutting-edge biological research and data-driven discoveries.

How does a Senior Bioinformatics Software Engineer typically collaborate with cross-functional teams in a research or clinical setting?

Senior Bioinformatics Software Engineers frequently work alongside biologists, data scientists, and clinicians to develop and maintain computational pipelines for data analysis. They play a key role in translating complex biological questions into scalable software solutions, often leading code reviews, mentoring junior developers, and ensuring data integrity. Regular meetings and clear communication are vital, as the role requires aligning technical development with scientific goals and regulatory requirements. This collaborative environment offers opportunities to influence project direction and contribute to impactful discoveries.

What does a Senior Bioinformatics Software Engineer do?

A Senior Bioinformatics Software Engineer designs, develops, and maintains software tools and pipelines to analyze biological data, such as genomic or proteomic information. They work closely with scientists and researchers to understand data requirements and translate them into efficient, scalable computational solutions. Their responsibilities often include coding, troubleshooting, optimizing algorithms, as well as mentoring junior engineers and contributing to project planning. Senior engineers are expected to have strong programming skills, a solid understanding of bioinformatics concepts, and experience working with large biological datasets.

What is the difference between Senior Bioinformatics Software Engineer vs Bioinformatics Software Engineer?

AspectSenior Bioinformatics Software EngineerBioinformatics Software Engineer
Required CredentialsBachelor's or Master's in Bioinformatics, Computer Science, or related field; experience in software development and bioinformatics toolsBachelor's or Master's in Bioinformatics, Computer Science, or related field; less emphasis on extensive experience
Work EnvironmentResearch labs, biotech companies, healthcare institutions, often leading projectsResearch teams, biotech firms, academic settings, supporting bioinformatics analysis
Employer & Industry UsageUsed in biotech, pharma, healthcare, research institutionsCommon in similar industries, often as entry to mid-level roles

The main difference between a Senior Bioinformatics Software Engineer and a Bioinformatics Software Engineer lies in experience and responsibility. Senior roles typically require more advanced skills, leadership, and project management, while entry-level roles focus on supporting bioinformatics analysis and software development. Both roles are vital in biotech and research industries, but senior positions involve greater oversight and strategic input.

More about Senior Bioinformatics Software Engineer jobs
What cities are hiring for Senior Bioinformatics Software Engineer jobs? Cities with the most Senior Bioinformatics Software Engineer job openings:
What are the most commonly searched types of Bioinformatics Software Engineer jobs? The most popular types of Bioinformatics Software Engineer jobs are:
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What job categories do people searching Senior Bioinformatics Software Engineer jobs look for? The top searched job categories for Senior Bioinformatics Software Engineer jobs are:
Infographic showing various Senior Bioinformatics Software Engineer job openings in the United States as of May 2026, with employment types broken down into 80% Full Time, 14% Part Time, 1% Temporary, and 5% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $102,271 per year, or $49.2 per hour.
Senior Bioinformatics Data Scientist

Senior Bioinformatics Data Scientist

Zel Technologies

Charlottesville, VA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 13 days ago


Job description

**This position is eligible for the $500 Zel Tech Non-Employee Referral fee. ContactZelTech Recruiters for questions concerning this matter. **

Locations: Charlottesville, McLean, or Reston, VA

Job Summary:

Zel Tech is seeking a highly qualified Bioinformatics Data Scientist that will provide SME support to our government customer in Charlottesville, Virginia.

Responsibilities:

The Bioinformatics Data Scientist shall aide in the following areas:

  • Directs and guides DNA/RNA sequence database searches and the computational analysis of resulting data.
  • Implement end-users’ needs in database searching and integration.
  • Maintain the computational infrastructure and controls the flow of samples and information for large-scale studies.
  • Provide web-based bioinformatics and access to public and proprietary relational databases.
  • Develop and applies computational tools.
  • Work in collaboration with drug discovery project
  • Provides direct support for bioinformatics, regex queries, developing and searching key words and biological ontologies.
  • Focused data discovery and retrieval from given datasets.
  • Accurately documents and maintains detailed records of activities to assure achievement of customer driven requirements.
  • Interface heavily with principal investigators, support staff and government technical leads.
  • Work under limited supervision, making complex decisions independently and referring unprecedented issues to government leadership.

Requirements:

  • Must be a US citizen.
  • Active TS/SCI clearance with CI Poly.
  • Three (3) or more years of experience safeguarding and handling classified material.
  • Bachelor’s degree in bioinformatics, computational / quantitative biology, computer science, engineering, statistics, applied mathematics or related quantitative field and ten (10) or more years of work experience.
  • Proficiency in statistical analysis.
  • Experience with data analysis and visualization.
  • Strong programming ability in Python
  • Self-teaching and mastering unfamiliar topics.
  • Successful background check.

Preferred Requirements:

  • Master’s degree and five (5) or more years of experience.
  • 5-10 years’ bio data experience with 5 years WMD-Bio intelligence.
  • DOD contracting experience.

Physical Demands or Work Environment:

The work environment characteristics and physical demands described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

  • The majority of the time is spent in an office setting.
  • Occasionally lift and/or move up to 25 pounds.
  • Specific vision abilities required include close vision, distance, vision, color vision and ability to adjust focus.
  • Frequently required to sit, use hands to finger, handle, or feel, and talk or hear.

About ZelTech:

Founded in 1988 by Ret. Col. Jack L. Ezzell Jr., Zel Technologies is a trusted leader in national security, providing comprehensive research, development, engineering, and operational support to the Department of Defense, the Intelligence Community, and federal agencies. Originally focused on leveraging operational and software expertise to improve time-critical targeting capabilities for the military, the company advanced its capabilities to provide scientific and HUMINT expertise for CBRNE collection and analysis. In the wake of 9/11, Zel Technologies rapidly expanded its capabilities to provide turnkey ISR support services to US Special Operations Forces (SOF), as well as advanced technical & operational intelligence, physical & data science, and engineering support services to the greater Intelligence and SOF Communities supporting global counterterrorism and CWMD operations.

Today, Zel Technologies remains at the forefront of intelligence missions, advancing CWMD and global counterterrorism efforts, while also addressing emerging threats posed by near-peer adversaries. Our team remains committed to delivering adaptive, innovative, and cost-effective solutions across multiple domains, in alignment with the mission priorities of the U.S. Government and its partner nations.


Our Mission:

Through our commitment to innovation and quality, our skilled teams deliver robust, technology driven solutions and insights that empower our customers to overcome complex challenges and achieve their mission objectives.


Our Workforce:

ZelTech team members represent a wide range of backgrounds, skills, experience, and personalities bound together by common objectives and mutual respect. You will join a caring community of professional, including many military veterans who challenge and support each other in seeking the right solutions to important matters.


Benefits:

  • Medical, Dental and Vision Insurance
  • 401k immediate vesting with company match
  • Flexible Spending Accounts
  • Health Savings Account with company contributions
  • Employee Assistance Program (EAP)
  • Bonuses for performance
  • Voluntary life/accidental death & dismemberment
  • Educational assistance and special training programs
  • Voluntary benefits (accidental, critical illness, whole life)
  • Group life insurance (Company paid)
  • Short-term and Long-term Disability Insurance (Company paid)
  • Paid Time Off (PTO), Holiday Leave, Jury Duty, and Military Leave
  • Health and fitness reimbursement
  • Referral bonuses
  • Employee discounts on various services and products


Equal Opportunities:

ZelTech is an equal opportunity employer and does not discriminate based on race, color, religion, creed, sex, age, sexual orientation, national origin, disability, marital status, military status, genetic predisposition, or any other basis protected by law.