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Senior Bioinformatics Software Engineer Jobs (NOW HIRING)

BiomeSense

Senior Bioinformatics Engineer

Chicago, IL · On-site

$125K - $200K/yr

Senior Bioinformatics Engineer Compensation: $125K - $200K base + 0.25% - 0.5% equity stock options ... Position Help build our MetaBiome platform, a software solution for collecting, curating ...

NYULMC

Senior Bioinformatics Programmer

New York, NY · On-site

Position Summary: We have an exciting opportunity to join our team as a Sr. Bioinformatics ... software engineering concepts • Knowledge of algorithms, data structures, machine learning • ...

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Senior Bioinformatics Software Engineer information

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How much do senior bioinformatics software engineer jobs pay per year?

As of Aug 7, 2026, the average yearly pay for senior bioinformatics software engineer in the United States is $102,271.00, according to ZipRecruiter salary data. Most workers in this role earn between $94,500.00 and $110,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a senior bioinformatics software engineer?

To thrive as a Senior Bioinformatics Software Engineer, you need a strong background in computer science, biology, and data analysis, often supported by an advanced degree in bioinformatics or a related field. Expertise with programming languages (such as Python, R, or Java), cloud computing, bioinformatics tools, and version control systems is typically required, along with experience using databases and relevant software frameworks. Strong problem-solving skills, collaboration, and effective communication are crucial soft skills for working with multidisciplinary teams and presenting complex data. These combined skills enable the effective development and maintenance of robust software tools that support cutting-edge biological research and data-driven discoveries.

How does a senior bioinformatics software engineer typically collaborate with cross-functional teams in a research or clinical setting?

Senior Bioinformatics Software Engineers frequently work alongside biologists, data scientists, and clinicians to develop and maintain computational pipelines for data analysis. They play a key role in translating complex biological questions into scalable software solutions, often leading code reviews, mentoring junior developers, and ensuring data integrity. Regular meetings and clear communication are vital, as the role requires aligning technical development with scientific goals and regulatory requirements. This collaborative environment offers opportunities to influence project direction and contribute to impactful discoveries.

What does a senior bioinformatics software engineer do?

A Senior Bioinformatics Software Engineer designs, develops, and maintains software tools and pipelines to analyze biological data, such as genomic or proteomic information. They work closely with scientists and researchers to understand data requirements and translate them into efficient, scalable computational solutions. Their responsibilities often include coding, troubleshooting, optimizing algorithms, as well as mentoring junior engineers and contributing to project planning. Senior engineers are expected to have strong programming skills, a solid understanding of bioinformatics concepts, and experience working with large biological datasets.

What is the difference between Senior Bioinformatics Software Engineer vs Bioinformatics Software Engineer?

AspectSenior Bioinformatics Software EngineerBioinformatics Software Engineer
Required CredentialsBachelor's or Master's in Bioinformatics, Computer Science, or related field; experience in software development and bioinformatics toolsBachelor's or Master's in Bioinformatics, Computer Science, or related field; less emphasis on extensive experience
Work EnvironmentResearch labs, biotech companies, healthcare institutions, often leading projectsResearch teams, biotech firms, academic settings, supporting bioinformatics analysis
Employer & Industry UsageUsed in biotech, pharma, healthcare, research institutionsCommon in similar industries, often as entry to mid-level roles

The main difference between a Senior Bioinformatics Software Engineer and a Bioinformatics Software Engineer lies in experience and responsibility. Senior roles typically require more advanced skills, leadership, and project management, while entry-level roles focus on supporting bioinformatics analysis and software development. Both roles are vital in biotech and research industries, but senior positions involve greater oversight and strategic input.

More about Senior Bioinformatics Software Engineer jobs
What cities are hiring for Senior Bioinformatics Software Engineer jobs? Cities with the most Senior Bioinformatics Software Engineer job openings:
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Senior Bioinformatics Software Engineer jobs near you
Infographic showing various Senior Bioinformatics Software Engineer job openings in the United States as of August 2026, with employment types broken down into 88% Full Time, 8% Part Time, and 4% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $102,271 per year, or $49.2 per hour.

Senior Bioinformatics Software Engineer

Morpheus Group

Houston, TX

Full-time

Posted 9 days ago

Job description

We are seeking an experienced Senior/Staff-Level Bioinformatics Software Engineer to provide technical leadership in the design, development, and enhancement of advanced bioinformatics software solutions. This role combines software engineering, computational biology, and data science expertise to support genomic data analysis, next-generation sequencing (NGS) workflows, and the development of scalable analytical platforms.
Key Responsibilities
  • Architect and develop innovative bioinformatics applications, analytical tools, and data processing solutions.
  • Lead the creation and optimization of genomic analysis pipelines focused on sequence interpretation, variant detection, and complex biological data analysis.
  • Partner with scientists, researchers, and cross-functional stakeholders to design studies, analyze results, and translate biological requirements into software solutions.
  • Drive technical strategy and contribute to architectural decisions for current and future software platforms.
  • Improve development processes through automation, best practices, and modern engineering methodologies.
  • Mentor engineering team members and serve as a technical resource across projects. Desired Qualifications
  • Strong background in bioinformatics software development with expertise in NGS data analysis and genomic workflows.
  • Experience working with common bioinformatics formats and tools, including sequencing alignment, variant analysis, and quality control frameworks.
  • Advanced programming skills in Python, R, or similar languages used in scientific computing.
  • Proficiency with Linux environments, cloud computing platforms, and workflow orchestration tools.
  • Experience with software development best practices, source control, testing methodologies, and containerized environments.
  • Excellent communication, leadership, and collaboration skills with the ability to work effectively across scientific and technical teams.

Background
  • Bachelor's degree in Computer Science, Bioinformatics, Data Science, Statistics, Mathematics, or a related field required; advanced degrees preferred.
  • Approximately 7+ years of experience in software engineering, bioinformatics, computational biology, or a related discipline, including demonstrated technical leadership.

This opportunity is ideal for a bioinformatics professional who enjoys leading complex technical initiatives, building scalable genomics solutions, and working at the intersection of software engineering and life sciences