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Senior Bioinformatics Software Engineer Jobs in Missouri

micro1 AI

Bioinformatics Software Engineer

Columbia, MO · Remote

$80 - $110/hr

Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods. * Curate, annotate, and validate chemical and ...

Tempus

Bioinformatics Engineer II

California, MO · On-site

$90 - $140/hr

## Bioinformatics Engineer IIApplylocations: Remote - Californiatime type: Full timeposted on: Posted ... Design and develop custom software according to ticket specifications* Act as a role model for the ...

Washington University of St. Louis

Evaluates commercial and academic bioinformatics software. * Work closely with wet-lab scientists ... Problem Solving, Java (Programming Language), Machine Learning (ML), Perl Programming ...

Mastercard, Inc.

Senior Software Engineer

O Fallon, MO · On-site

$114K - $151K/yr

Title and Summary Senior Software Engineer Overview Mastercard's Network & Digital Payments group creates meaningful digital payment experiences for consumers, merchants, issuers, and partners at ...

MasterCard

Senior Software Engineer

O Fallon, MO

$114K - $151K/yr

Title and Summary Senior Software Engineer Overview Mastercard's Network & Digital Payments group creates meaningful digital payment experiences for consumers, merchants, issuers, and partners at ...

MasterCard

Senior Software Engineer

O Fallon, MO · On-site

$114K - $151K/yr

Title and Summary Senior Software Engineer Who We Are Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we're helping build a ...

Mastercard, Inc.

Senior Software Engineer

O Fallon, MO · On-site

$114K - $151K/yr

Title and Summary Senior Software Engineer Who We Are Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we're helping build a ...

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All JobsBioinformatics Software Engineer JobsSenior Bioinformatics Software Engineer JobsSenior Bioinformatics Software Engineer Jobs in Missouri

Senior Bioinformatics Software Engineer information

See Missouri salary details

$79.3K

$95.9K

$112.1K

How much do senior bioinformatics software engineer jobs pay per year?

As of Aug 24, 2026, the average yearly pay for senior bioinformatics software engineer in Missouri is $95,931.00, according to ZipRecruiter salary data. Most workers in this role earn between $88,600.00 and $103,200.00 per year, depending on experience, location, and employer.

What does a senior bioinformatics software engineer do?

A Senior Bioinformatics Software Engineer designs, develops, and maintains software tools and pipelines to analyze biological data, such as genomic or proteomic information. They work closely with scientists and researchers to understand data requirements and translate them into efficient, scalable computational solutions. Their responsibilities often include coding, troubleshooting, optimizing algorithms, as well as mentoring junior engineers and contributing to project planning. Senior engineers are expected to have strong programming skills, a solid understanding of bioinformatics concepts, and experience working with large biological datasets.

What are the key skills and qualifications needed to thrive as a senior bioinformatics software engineer?

To thrive as a Senior Bioinformatics Software Engineer, you need a strong background in computer science, biology, and data analysis, often supported by an advanced degree in bioinformatics or a related field. Expertise with programming languages (such as Python, R, or Java), cloud computing, bioinformatics tools, and version control systems is typically required, along with experience using databases and relevant software frameworks. Strong problem-solving skills, collaboration, and effective communication are crucial soft skills for working with multidisciplinary teams and presenting complex data. These combined skills enable the effective development and maintenance of robust software tools that support cutting-edge biological research and data-driven discoveries.

How does a senior bioinformatics software engineer typically collaborate with cross-functional teams in a research or clinical setting?

Senior Bioinformatics Software Engineers frequently work alongside biologists, data scientists, and clinicians to develop and maintain computational pipelines for data analysis. They play a key role in translating complex biological questions into scalable software solutions, often leading code reviews, mentoring junior developers, and ensuring data integrity. Regular meetings and clear communication are vital, as the role requires aligning technical development with scientific goals and regulatory requirements. This collaborative environment offers opportunities to influence project direction and contribute to impactful discoveries.

What is the difference between Senior Bioinformatics Software Engineer vs Bioinformatics Software Engineer?

AspectSenior Bioinformatics Software EngineerBioinformatics Software Engineer
Required CredentialsBachelor's or Master's in Bioinformatics, Computer Science, or related field; experience in software development and bioinformatics toolsBachelor's or Master's in Bioinformatics, Computer Science, or related field; less emphasis on extensive experience
Work EnvironmentResearch labs, biotech companies, healthcare institutions, often leading projectsResearch teams, biotech firms, academic settings, supporting bioinformatics analysis
Employer & Industry UsageUsed in biotech, pharma, healthcare, research institutionsCommon in similar industries, often as entry to mid-level roles

The main difference between a Senior Bioinformatics Software Engineer and a Bioinformatics Software Engineer lies in experience and responsibility. Senior roles typically require more advanced skills, leadership, and project management, while entry-level roles focus on supporting bioinformatics analysis and software development. Both roles are vital in biotech and research industries, but senior positions involve greater oversight and strategic input.

What are the most commonly searched types of Bioinformatics Software Engineer jobs in Missouri?

The most popular types of Bioinformatics Software Engineer jobs in Missouri are:

What cities in Missouri are hiring for Senior Bioinformatics Software Engineer jobs?

Cities in Missouri with the most Senior Bioinformatics Software Engineer job openings:

Senior Bioinformatics Software Engineer jobs near you
Infographic showing various Senior Bioinformatics Software Engineer job openings in Missouri as of August 2026, with employment types broken down into 88% Full Time, 8% Part Time, and 4% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $95,931 per year, or $46.1 per hour.

Bioinformatics Software Engineer

micro1 AI

Saint Louis, MO • Remote

$80 - $110/hr

Part-time

Posted 21 days ago

Job description

Role Title: Computational Biology & Cheminformatics Expert


Role Type: Contractor


Location: Remote


micro1 is engaging Computational Biology & Cheminformatics Experts to contribute their expertise to a customer’s computational drug discovery project. In this role, you'll apply your expertise to help train next-generation AI systems. Your work will shape how models learn, reason, and perform through high-quality, real-world input. No prior experience in AI is required — your domain knowledge is what matters.


Scope of Work

  1. Analyze and interpret small-molecule and drug discovery datasets using advanced computational biology, bioinformatics, and cheminformatics methods.
  2. Curate, annotate, and validate chemical and biological datasets (e.g., ChEMBL, PubChem, DrugBank) to support AI-driven discovery platforms.
  3. Evaluate compound-target interactions, ADMET properties, and lead optimization strategies by integrating chemical, biological, and clinical data sources.
  4. Provide expert insights on structure-activity and structure-property relationships (SAR/SPR), medicinal chemistry approaches, and experimental design considerations.
  5. Build and implement code-based benchmark tasks (e.g., terminal/CLI-based environments) that reflect realistic computational drug discovery scenarios.
  6. Develop reproducible environments (e.g., using Docker) and automated testing pipelines to ensure task correctness and solvability.
  7. Assess and review AI-generated outputs for scientific rigor, accuracy, and practical relevance, delivering detailed written feedback and recommendations.


Preferred Qualifications

  1. Advanced expertise in Computational Biology, Cheminformatics, Medicinal Chemistry, Biochemistry, or related fields; advanced degree (PhD, MSc, PharmD) highly valued but not strictly required.
  2. Strong coding proficiency in Python (beyond analysis scripts), with hands-on experience building tools, pipelines, or testable code; familiarity with Git, GitHub, and Docker.
  3. Extensive experience with cheminformatics toolkits and platforms such as RDKit, KNIME, Schrödinger, OpenEye, or MOE.
  4. Proven track record in small-molecule drug discovery, SAR/QSAR evaluation, ADMET prediction, or virtual screening workflows.
  5. Comfort working with public chemical and bioactivity databases and integrating diverse datasets for scientific analysis.
  6. Demonstrated ability to clearly communicate complex chemical and biological concepts in written feedback and reports.
  7. Experience participating in multidisciplinary and/or remote projects; familiarity with AI-assisted coding tools is a plus.

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