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Senior Bioinformatics Software Engineer Jobs in Illinois

BiomeSense

Senior Bioinformatics Engineer

Chicago, IL · On-site

$125K - $200K/yr

Senior Bioinformatics Engineer Compensation: $125K - $200K base + 0.25% - 0.5% equity stock options ... Position Help build our MetaBiome platform, a software solution for collecting, curating ...

Langara

Instructor, Bioinformatics

Campus, IL · On-site

Protein Engineering Applications focuses oncomputationalanalysis, prediction, design, and ... Computer literacy, including experience with bioinformatics software, biological databases, and ...

University of Utah

Bioinformatics Management

Campus, IL · Hybrid

$110K - $122K/yr

A senior scientific, clinical informatics, and team-leadership role. It serves as the primary ... Full-stack software engineering, data persistence, and application delivery. * Operations ...

University of Utah

Bioinformatics Management

Campus, IL · Hybrid

$110K - $122K/yr

A senior scientific, clinical informatics, and team-leadership role. It serves as the primary ... Full-stack software engineering, data persistence, and application delivery. * Operations ...

University of Utah

Bioinformatics Management

Campus, IL · Hybrid

$110K - $122K/yr

A senior scientific, clinical informatics, and team-leadership role. It serves as the primary ... Full-stack software engineering, data persistence, and application delivery. * Operations ...

Tempus

Senior Software Engineer II, Data Products

Chicago, IL · On-site

$126K - $166K/yr

The Role As a Senior Software Engineer II on the Data Products team, you will act as a technical ... bioinformatics scientists, ML and Agent developers to rapidly develop, deploy, and operate their ...

Tempus

Senior Software Engineer, OS Ecosystem

Chicago, IL · On-site

$110K - $160K/yr

The Role As a Senior Software Engineer on the OS Ecosystem team, you will act as a core technical ... You will play a pivotal role in designing and developing systems that allow bioinformatics ...

Ritchie Bros.

Senior Software Engineer

Gardena, CA · On-site

$124K - $164K/yr

The Senior Software Engineer designs and delivers features and services using Microsoft technologies, work with software engineers and product team, and contributes to architectural decisions. This ...

Humana

Senior Software Engineer

Chicago, IL · On-site +1

$126K - $166K/yr

The Senior Software Engineer work assignments involve moderately complex to complex issues where the analysis of situations or data requires an in-depth evaluation of variable factors. ** This ...

IMG LIVE

Senior Software Engineer

Chicago, IL · On-site

$131.25 - $175/hr

Senior Software Engineer page is loaded## Senior Software Engineerlocations: Remote-CA: Remote-WA: Remote-CO: Remote-NY: Remote-OR(PT)posted on: Posted Todayjob requisition id: JR28401## **Senior ...

Humana

Senior Software Engineer

Chicago, IL · On-site +1

$126K - $166K/yr

The Senior Software Engineer work assignments involve moderately complex to complex issues where the analysis of situations or data requires an in-depth evaluation of variable factors. ** This ...

Humana

Senior Software Engineer

Chicago, IL · On-site +1

$126K - $166K/yr

The Senior Software Engineer work assignments involve moderately complex to complex issues where the analysis of situations or data requires an in-depth evaluation of variable factors. ** This ...

Inspira Financial

Sr. Software Engineer (Remote)

Oak Brook, IL · On-site +1

$123K - $163K/yr

We are seeking talented Senior Software Engineers who can create complex .NET back-end solutions and scalable user experiences while collaborating with an experienced team of product development ...

Northgate Technologies Inc.

Senior Software Engineer

Elgin, IL · On-site

$121K - $159K/yr

The Senior Software Engineer for the Product Development team is responsible for developing and sustaining software controlled electro-mechanical medical devices for minimally invasive surgery. The ...

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Senior Bioinformatics Software Engineer information

See Illinois salary details

$81.9K

$99.1K

$115.8K

How much do senior bioinformatics software engineer jobs pay per year?

As of Aug 11, 2026, the average yearly pay for senior bioinformatics software engineer in Illinois is $99,103.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,600.00 and $106,600.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a senior bioinformatics software engineer?

To thrive as a Senior Bioinformatics Software Engineer, you need a strong background in computer science, biology, and data analysis, often supported by an advanced degree in bioinformatics or a related field. Expertise with programming languages (such as Python, R, or Java), cloud computing, bioinformatics tools, and version control systems is typically required, along with experience using databases and relevant software frameworks. Strong problem-solving skills, collaboration, and effective communication are crucial soft skills for working with multidisciplinary teams and presenting complex data. These combined skills enable the effective development and maintenance of robust software tools that support cutting-edge biological research and data-driven discoveries.

How does a senior bioinformatics software engineer typically collaborate with cross-functional teams in a research or clinical setting?

Senior Bioinformatics Software Engineers frequently work alongside biologists, data scientists, and clinicians to develop and maintain computational pipelines for data analysis. They play a key role in translating complex biological questions into scalable software solutions, often leading code reviews, mentoring junior developers, and ensuring data integrity. Regular meetings and clear communication are vital, as the role requires aligning technical development with scientific goals and regulatory requirements. This collaborative environment offers opportunities to influence project direction and contribute to impactful discoveries.

What does a senior bioinformatics software engineer do?

A Senior Bioinformatics Software Engineer designs, develops, and maintains software tools and pipelines to analyze biological data, such as genomic or proteomic information. They work closely with scientists and researchers to understand data requirements and translate them into efficient, scalable computational solutions. Their responsibilities often include coding, troubleshooting, optimizing algorithms, as well as mentoring junior engineers and contributing to project planning. Senior engineers are expected to have strong programming skills, a solid understanding of bioinformatics concepts, and experience working with large biological datasets.

What is the difference between Senior Bioinformatics Software Engineer vs Bioinformatics Software Engineer?

AspectSenior Bioinformatics Software EngineerBioinformatics Software Engineer
Required CredentialsBachelor's or Master's in Bioinformatics, Computer Science, or related field; experience in software development and bioinformatics toolsBachelor's or Master's in Bioinformatics, Computer Science, or related field; less emphasis on extensive experience
Work EnvironmentResearch labs, biotech companies, healthcare institutions, often leading projectsResearch teams, biotech firms, academic settings, supporting bioinformatics analysis
Employer & Industry UsageUsed in biotech, pharma, healthcare, research institutionsCommon in similar industries, often as entry to mid-level roles

The main difference between a Senior Bioinformatics Software Engineer and a Bioinformatics Software Engineer lies in experience and responsibility. Senior roles typically require more advanced skills, leadership, and project management, while entry-level roles focus on supporting bioinformatics analysis and software development. Both roles are vital in biotech and research industries, but senior positions involve greater oversight and strategic input.

What are the most commonly searched types of Bioinformatics Software Engineer jobs in Illinois? The most popular types of Bioinformatics Software Engineer jobs in Illinois are:
Senior Bioinformatics Software Engineer jobs near you

Senior Bioinformatics Engineer

BiomeSense

Chicago, IL • On-site

$125K - $200K/yr

Full-time

Re-posted 20 days ago

Job description

Senior Bioinformatics Engineer
Compensation: $125K – $200K base +  0.25% - 0.5% equity stock options
About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome (GMB) technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.
Position
Help build our MetaBiome platform, a software solution for collecting, curating & analyzing longitudinal GMB & health data at scale. Own the infra, pipelines & analytical workflows that turn raw sequencing data into intelligence, with room to grow into a platform leader.
Responsibilities:
  • Bioinformatics Architecture & Infrastructure - design, implement & maintain auditable backend for GMB data from raw shotgun metagenomic sequencing
  • Data Engineering – build & maintain cloud infra: databases, distributed computing workflows & REST endpoints for microbial sequence & clinical metadata
  • Statistical Analysis – Lead design, execution & documentation of reproducible computational experiments end-to-end
  • Methods Development – Develop & implement novel analytical methodologies & algorithms informed by experimental findings & validated via rigorous evaluation
  • Frontend / Backend Development – Design & implement robust data ingestion interfaces leveraging APIs & clinical ontologies, following best practices

Qualifications
Required
  • B.S. /M.S. /PhD in Computational Biology, Bioinformatics or a related field with 3+ yrs industry experience (biotech start-up ideal)
  • Proficiency in Python & JavaScript & experience in production-quality software
  • PostgreSQL or other relational SQL database proficiency
  • Familiarity with clinical ontologies (SNOMED, ICD-11, ATC, LOINC)
  • Familiarity with AWS & best practices in computer security
  • Proficiency with modern frontend web technologies
  • Excellent communication; translates complex scientific concepts to diverse stakeholders
  • Strong ownership mindset & the ability to execute in fast-moving environments
  • Expertise in bioinformatics pipelines, QC & reproducibility

Preferred
  • NGS data experience
  • Familiarity with longitudinal / repeated-measures biological datasets & GMB-specific challenges (compositional data, variability, confounders)
  • Experience integrating ontologies / standardized vocabularies
  • Exposure to cloud infrastructure, workflow orchestration or containerization
  • Interest in AI/ML for large biological datasets

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