ZipRecruiter

Log In

1

Downstream Process Jobs (NOW HIRING)

Agilent

Process Engineer, Downstream

Frederick, CO · On-site

$124.16K - $194K/yr

Technical lead for downstream processes and unit operations. Responsible for process modeling and consulted on process fit and throughput assessments. * Responsible for process design review for ...

Legend Biotech USA, Inc.

Role OverviewThe Principal Scientist, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for ...

next page

Showing results 1-20

People also search for

All JobsDownstream Process Jobs

Downstream Process information

See salary details

$13

$24

$35

How much do downstream process jobs pay per hour?

As of Jun 4, 2026, the average hourly pay for downstream process in the United States is $24.67, according to ZipRecruiter salary data. Most workers in this role earn between $19.71 and $28.12 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

More about Downstream Process jobs
What cities are hiring for Downstream Process jobs? Cities with the most Downstream Process job openings:
What states have the most Downstream Process jobs? States with the most job openings for Downstream Process jobs include:
What job categories do people searching Downstream Process jobs look for? The top searched job categories for Downstream Process jobs are:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in the United States as of May 2026, with employment types broken down into 1% Internship, 4% As Needed, 4% Full Time, 75% Part Time, 2% Temporary, and 14% Contract. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $51,319 per year, or $24.7 per hour.
Process Development Research Associate I/II - Downstream

Process Development Research Associate I/II - Downstream

KBI Biopharma, Inc.

Durham, NC

$55K - $75.90K/yr

Full-time

Posted 24 days ago

Job description

Position Summary

Responsible for supporting process development activities for downstream production processes, instruments and equipment.

Position Responsibilities

  • Support all downstream process development activities including execution of experiments, compilation and analysis of data and drafting of technical documents.

  • Assist in the evaluation, development and implementation of new downstream technologies leading to process improvements and efficiency of operation.

  • Assist with development of preliminary schedules along with material/personnel/equipment requirements to allow accurate and appropriate performance guarantees

  • Equipment troubleshooting and maintenance

  • General lab organization

Minimum Requirements

  • B.S. degree in biotechnology or related (or equivalent training) with 0-4 years experience or a M.S. degree with 0-2 years experience.

  • Research Associate II requires a B.S. degree and 2+ years experience or a M.S. degree.

  • Experience with downstream process development and chromatography equipment required. Excellent written and communication skills for customer service and ability to meet strict client deadlines. Flexibility of hours to support downstream processes. Knowledge of GMPs and biotechnology-derived product regulations preferred.

Salary:

Process Development Associate I: $55,000-$75,900

Process Development Associate II: $63,000-$86,900

KBI Biopharma, Inc. is an EEO/AA employer and actively seeks to diversify its work force. Therefore, all qualified applicants, regardless of race, color, national origin, religion, gender, gender identity, sexual orientation, age, disability or veteran status, are strongly encouraged to apply.

I understand that neither the completion of this application nor any other part of my consideration for employment establishes any obligation for KBI Biopharma, Inc. to hire me. If I am hired, I understand that either KBI Biopharma, Inc. or I can terminate my employment at any time and for any reason, with or without cause and without prior notice. I understand that no representative of KBI Biopharma, Inc. has the authority to make any assurance to the contrary.

I attest with my signature below that I have given to KBI Biopharma, Inc. true and complete information on this application. No requested information has been concealed. I authorize KBI Biopharma, Inc. to contact references provided for employment reference checks. If any information I have provided is untrue, or if I have concealed material information, I understand that this will constitute cause for the denial of employment or immediate dismissal.

Apply