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Director Downstream Engineer Jobs (NOW HIRING)

Stryker

Director Downstream Marketing

Tempe, AZ

$155.90K - $259.70K/yr

Talent developers. Growth-oriented managers who recruit and hire top-performing talent and prioritize the development of their team members. Goal-oriented orchestrators. People who can effectively ...

Stryker

Director Downstream Marketing

Tempe, AZ · On-site

$155.90K - $259.70K/yr

Hybrid or Onsite Who we want: • Talent developers. Growth-oriented managers who recruit and hire top-performing talent and prioritize the development of their team members. • Goal-oriented ...

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Director Downstream Engineer information

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$59.5K

$111.6K

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How much do director downstream engineer jobs pay per year?

As of May 30, 2026, the average yearly pay for director downstream engineer in the United States is $111,632.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,500.00 and $132,500.00 per year, depending on experience, location, and employer.

What is the difference between Director Downstream Engineer vs Process Engineer?

AspectDirector Downstream EngineerProcess Engineer
CredentialsBachelor's/Master's in Chemical Engineering, extensive industry experienceBachelor's/Master's in Chemical or Process Engineering, relevant certifications
Work EnvironmentLeadership roles overseeing teams and projects in manufacturing plantsDesign, optimize, and troubleshoot processes in production facilities
Industry UsageCommon in large-scale chemical, oil & gas, and pharmaceutical companiesFound across similar industries, often in operational or technical roles

The main difference is that a Director Downstream Engineer typically holds a leadership position overseeing downstream processes, while a Process Engineer focuses on designing and improving specific processes. The Director role involves strategic planning and team management, whereas the Process Engineer is more hands-on with technical process optimization.

What cities are hiring for Director Downstream Engineer jobs? Cities with the most Director Downstream Engineer job openings:
What are the most commonly searched types of Downstream Engineer jobs? The most popular types of Downstream Engineer jobs are:
What states have the most Director Downstream Engineer jobs? States with the most job openings for Director Downstream Engineer jobs include:
What job categories do people searching Director Downstream Engineer jobs look for? The top searched job categories for Director Downstream Engineer jobs are:
Director Downstream Engineer jobs near you
Infographic showing various Director Downstream Engineer job openings in the United States as of May 2026, with employment types broken down into 94% Full Time, and 6% Contract. Highlights an 94% In-person, and 6% Remote job distribution, with an average salary of $111,632 per year, or $53.7 per hour.
Director, Downstream Process Development

Director, Downstream Process Development

Allakos

Redwood City, CA

Full-time

Posted 19 days ago

Job description

Director, Downstream Process Development
Allakos Inc. is a clinical-stage company developing therapeutic antibodies for inhibitory receptors on the surface of immune effector cells involved in allergic, inflammatory and proliferative diseases.
Allakos is committed to developing innovative therapies that transform patients’ lives. We are looking for bright and talented individuals to join our team and share in our passion and commitment to improving the lives of patients.
Position Summary:
The Director, Downstream Process Development would be key member of Biologics DS development and tech transfer team and would be responsible for all activities related to Downstream Process Development of our late-stage clinical biologics (Mab) molecule AK002 and early stage program. This position leads the Purification Group which is responsible for the process development, tech transfer, supervision of Engineering and Clinical batches, BLA enabling activities, PPQ Batches and commercial production at multiple CMO sites, process characterization and BLA authoring and review.
Your Role:
  • Provide technical and managerial leadership to the Downstream Process Development group and technology transfer of AK002 process to CMO sites.
  • Accountable for all activities pertaining to the downstream process development lab. Supervise planning and execution of experiments. Analyze results and communicate it effectively to management.
  • Coordinate with Upstream development, Analytical and Facilities department to successfully complete the DSP activities
  • Provide overall strategy and experimental plan for downstream process characterization studies. Generate protocols, supervise execution, use statistical tools to analyze results and review reports for studies.
  • Plan the downstream process development experiments for new molecules and supervise execution of the same.
  • Supervise the Engineering and Clinical batches at the CMOs, Review and approve Batch records, Bill of Materials, Bill of Parameters, Batch records, deviations and CAPA documents for these batches
  • Plan and supervise PPQ batches at CMOs. Review and approve protocols and reports for PPQ batches
  • Author and review BLA submission documents
  • Lead cross functional meetings with Quality, Regulatory, Supply Chain, Process Development, Analytical and Drug Product to build consensus on key issues and facilitate decision making to move the project forward
  • Travel domestically and internationally up to 10% of the time
Qualifications and Expertise:
  • At least 15 years of relevant experience (12+ with MS, 10+ for PhD) successfully working in biopharmaceutical industry with proven track record of leadership and success
  • At least 8 years managing cross functional projects and leading teams
  • Extensive experience in Downstream process development and process characterization of biologics molecules such as Mabs and fusion proteins.
  • Experience in technology transfer and facility fit assessments
  • Should have worked with early and late stage and commercial biologics with experience in process development, process characterization, PPQ batches and other BLA enabling studies and CPV programs.
  • Experience working with Contract Manufacturers is preferred.
  • Experienced in BLA submission write ups.
  • Experience in people and stakeholder management, conflict resolution and building consensus.
  • Good understanding of cGMP-regulations including relevant US/EU regulatory and quality requirements, practices, and standards.
  • Exceptional interpersonal skills to establish positive relationships with internal stakeholders, CROs/CMOs, and multi-functional/multi-cultural teams.
  • Ability to travel at least 10% of the time.
The salary is competitive and commensurate with experience and qualifications.
The Allakos Values are: Selflessness, Drive, Clarity, Thoughtfulness, Fun, and Leadership
Allakos is an equal opportunity employer. Allakos will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or
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About Allakos

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

51 - 200 Employees

Headquarters location

Redwood City, CA, US

Year founded

2012

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