ZipRecruiter

Log In

1

Director Downstream Engineer Jobs (NOW HIRING)

Actalent

GMP Lead (Downstream)

Grove City, OH · On-site

$93K - $100K/yr

Train and mentor junior technicians; perform periodic review of direct reports. * Report unexpected ... About Actalent Actalent is a global leader in engineering and sciences services and talent ...

InfiCare

Anaplan Integration Engineer

Atlanta, GA · On-site

$100K - $134K/yr

Collaboration with Anaplan Model Builders and downstream engineering teams is a core part of the ... T Recruiter InfiCare Staffing | 22375 Broderick Drive #225 Dulles, VA 20166 Direct: +1 | | Staffing ...

previous page

Showing results 41-60

All JobsEngineering JobsEngineers JobsDirector Downstream Engineer Jobs

Director Downstream Engineer information

See salary details

$59.5K

$111.6K

$203K

How much do director downstream engineer jobs pay per year?

As of Sep 14, 2026, the average yearly pay for director downstream engineer in the United States is $111,632.00, according to ZipRecruiter salary data. Most workers in this role earn between $80,500.00 and $132,500.00 per year, depending on experience, location, and employer.

What is the difference between Director Downstream Engineer vs Process Engineer?

AspectDirector Downstream EngineerProcess Engineer
CredentialsBachelor's/Master's in Chemical Engineering, extensive industry experienceBachelor's/Master's in Chemical or Process Engineering, relevant certifications
Work EnvironmentLeadership roles overseeing teams and projects in manufacturing plantsDesign, optimize, and troubleshoot processes in production facilities
Industry UsageCommon in large-scale chemical, oil & gas, and pharmaceutical companiesFound across similar industries, often in operational or technical roles

The main difference is that a Director Downstream Engineer typically holds a leadership position overseeing downstream processes, while a Process Engineer focuses on designing and improving specific processes. The Director role involves strategic planning and team management, whereas the Process Engineer is more hands-on with technical process optimization.

What cities are hiring for Director Downstream Engineer jobs?

Cities with the most Director Downstream Engineer job openings:

What are the most commonly searched types of Downstream Engineer jobs?

The most popular types of Downstream Engineer jobs are:

What states have the most Director Downstream Engineer jobs?

States with the most job openings for Director Downstream Engineer jobs include:

What are popular job titles related to Director Downstream Engineer jobs?

For Director Downstream Engineer jobs, the most frequently searched job titles are:

Director Downstream Engineer jobs near you
Infographic showing various Director Downstream Engineer job openings in the United States as of September 2026, with employment types broken down into 2% As Needed, 85% Full Time, 12% Part Time, and 1% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $111,632 per year, or $53.7 per hour.

(Associate) Director, Viral Downstream Process Development

Philadelphia, PA • On-site

Dispatch Bio
See more jobs at Dispatch Bioexternal

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 2 days ago

Job description

About us:
Our purpose at Dispatch is to help create a world where all cancer patients can be cured. We're humbled by the opportunity to work together as a team on some of the most pressing medical challenges of our time.
To achieve our purpose, we are dedicated to engineering a universal treatment across solid tumors. We're committed to the development of novel therapies, leveraging first-in-class technologies in viral vectors, universal targets, and novel cytokine biology. Our therapeutic approach has the potential to enable us to treat significant numbers of cancer patients and make a real and lasting impact on the world.
Our company was founded on pioneering work carried out in the laboratories of Dr. Carl June (University of Pennsylvania), Dr. Kole Roybal (University of California, San Francisco), Dr. Christopher Garcia (Stanford University) and Dr. Andy Minn (Memorial Sloan Kettering Cancer Center).
At our company, you would become one of our early team members- not only playing a role in meeting our ambitious mission but also building our thriving culture. We are determined to deliver with urgency to discover new solutions and we always stay dedicated to scientific rigor; we have an ownership mindset because each and every one of us is integral to our success. Collaboration is core for us because we believe that by bringing people together with diverse perspectives, we make a stronger whole. And, we show we care about our work and each other by sharing feedback - ultimately in service of our vision to empower people to continue forward with their lives - cancer free.
The role:
The (Associate) Director will serve as the downstream processing expert working closely with CDMOs to generate lentivirus and adenovirus products. Reporting into the Vice President of Process Development, this individual will also be responsible for building out the internal downstream purification capabilities within process development to support scale up and scale down.
Key responsibilities:
  • Oversee planning and execution of tech transfers, development and scale up of viral products being manufactured at CDMOs
  • Serve as the downstream subject matter expert on both internal and external (CDMO, equipment suppliers, etc.) teams
  • Build out internal downstream capabilities by identifying/procuring scale down models for process development
  • Design and execute studies to identify critical process parameters and optimize process setpoints across the clarification, Tangential Flow Filtration (TFF), chromatography and sterile filtration steps
  • Responsibility for execution, data review, analysis, and maintaining accurate and detailed lab notebooks
  • Author and review technical documents, including but not limited batch records, SOPs and development reports and process-specific sections of regulatory documents.
  • Represent the company externally at meetings (professional associations, with regulatory bodies, etc.)
  • Work cross-functionally with analytical development, research and development, program management to advance clinical programs

Required experience & skills:
  • MS or Ph.D. in Chemical Engineering, Bioengineering or related discipline
  • Minimum of 10 years of experience with downstream purification process development in the biopharma industry
  • Experience directly managing a team
  • Technical experience with downstream unit operations including clarification, TFF, chromatography, sterile filtration and formulation
  • Experience with scale up and scale down of purification processes
  • An understanding of cGMP and regulatory requirements for biopharmaceuticals
  • Strong organizational & problem-solving skills, with the proven ability to collaborate in a dynamic team environment
  • Strong scientific reasoning, problem-solving, and applied statistics skills, including the ability to break down complex problems into manageable hypotheses
  • Proficiency in using Microsoft Word, Excel, Power Point and data analysis/presentation software such as JMP and/or GraphPad
  • Excellent interpersonal, verbal and written communication skills.
  • Excellent organizational and planning skills, strong work ethic and the desire to work in a flexible and fast-paced, entrepreneurial environment

Preferred experience & skills:
  • Experience with Quality by Design (QbD) approach to drug development including risk assessments, Design of Experiments (DoE) and statistical methods
  • Experience drafting CMC sections for INDs
  • Experience with technology transfers to external manufacturing facilities

Our values:
Our values guide everything we do. While capabilities and skills are vital, understanding how a potential new colleague would embody our values is central to our hiring decisions.
Determined to deliver:
By working with focus and passion, we can provide patients with the solutions they need.
Own every outcome:
We can reach new heights when we stay centered on our shared success.
Collaboration at the core:
When we band together, our work is better.
Feedback is fundamental:
Constructive and authentic positive feedback may be difficult to master but it is vital to our success.
Working here:
  • We offer a highly competitive compensation package with meaningful ownership through equity
  • Excellent coverage for medical, vision, and dental
  • 401(k) with generous contribution
  • Life insurance
  • Flexible PTO policy
  • Additional substantial benefits

We are an equal opportunity employer.
We do not discriminate on the basis of race, religion, gender, sexual orientation, age, marital status, veteran status, disability status, national origin, or any characteristic protected under applicable law.

Apply