Manager Downstream Engineer Jobs (NOW HIRING)

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Job Description
Join Takeda as a Downstream Process Development, Engineer III. As a solid professional, you receive assignments with objectives and goals, providing guidance to employees based on established policies. Your work is reviewed by management to assess goal achievement and adherence to policies, with opportunities to recommend policy changes within your unit or sub-unit. You address moderate scope problems, applying judgment within defined procedures and policies, and act as an advisor when needed. Your role involves frequent use of industry practices and general knowledge, ensuring project completion on schedule, primarily liaising internally with subordinates and supervisors, with minimal external contacts and guidance.
About this role:
The Downstream Process Development Engineer III is responsible for supporting downstream biotherapeutics process development through hands-on purification and recovery experiments. In this individual contributor role, you will support process development across multiple scales, from micro scale through bench and pilot scale, and contribute to both early-stage and late-stage programs. You will work with more senior process engineers to plan and execute larger experiments, while also partnering with process development team members to generate data, maintain accurate records, and contribute to the development and optimization of downstream processes. As an Engineer III in downstream process development, you will contribute independently within established procedures, use sound judgment in routine problem solving, and support project delivery on schedule.
How you will contribute:
• Execute chromatography, harvest operations, ultrafiltration and diafiltration, and viral clearance experiments, with additional potential support of bioconjugation
• Support downstream process development across micro scale, bench scale, and pilot scale studies
• Maintain laboratory equipment and support routine readiness of instruments used in process development work
• Work with more senior process engineers to plan and execute larger experiments and study activities
• Document experimental work in electronic laboratory notebooks and maintain clear, complete, and timely records
• Perform basic data analysis to review trends, compare conditions, and support study conclusions
• Prepare technical summaries, study updates, and other written materials to share results and findings
• Follow established laboratory and process development procedures, including quality and safety requirements
• Contribute to continuous improvement efforts by identifying ways to improve workflows, data capture, and experimental execution
• Assist with small projects or specific project tasks under close supervision
• Apply judgment within defined procedures and policies to address moderate scope problems and support timely project completion
• Serve as a reliable advisor to peers and junior team members when needed, while keeping work aligned with team goals and manager guidance
What you bring to Takeda:
• Bachelor's degree with 2 or more years of relevant experience, or master's degree with relevant experience, in chemical engineering, chemistry, biochemistry, biotechnology, or a related field
• Experience with chromatography, harvest, ultrafiltration and diafiltration, and viral clearance steps
• Some relevant experience in process development, protein purification, or a related laboratory setting
• Experience with basic bioprocess control systems
• Experience using electronic laboratory notebooks for study documentation and data entry
• Ability to perform basic data analysis and present results clearly in written form
• Familiarity with technical writing for laboratory reports or development documents
• Understanding of laboratory practices, process development methods, and quality requirements
• Ability to follow detailed procedures, maintain accurate records, and work under close supervision
• Comfort with emerging digital tools and openness to artificial intelligence-enabled processes that support data analysis, documentation, and workflow improvement
Important Considerations:
At Takeda, our patients rely on us to deliver quality products. As a result, we must follow strict rules in our manufacturing facilities to ensure we are not endangering the quality of the product. In this role, you may:

• Work in a controlled environment requiring special gowning and wear protective clothing over the head, face, hands, feet and body. This may include additional hearing protection for loud areas.
• Need to remove all make-up, jewelry, contact lenses, nail polish and/or artificial fingernails while in the manufacturing environment.
• Work in a cold, wet environment.
• Work multiple shifts, including weekends, or be asked to work supplemental hours, as necessary.
• Work around chemicals such as alcohol, acids, buffers and Celite that may require respiratory protection.

More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
#GMSGQ #ZR1 #LI-MA1
Takeda Compensation and Benefits Summary
We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.
For Location:
Lexington, MA
U.S. Base Salary Range:
$89,900.00 - $141,240.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.
U.S. based employees may be eligible for short-term and/ or long-term incentives. U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations
Lexington, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time
Job Exempt
Yes
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.