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Downstream Process Engineer Jobs (NOW HIRING)

Agilent

Process Engineer, Downstream

Frederick, CO · On-site

$124.16K - $194K/yr

Join a growing team with this exciting new opportunity for an expert level Downstream Process Engineer. Work on a dynamic, fast-paced, large capacity oligonucleotide API production facility design ...

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$49.5K

$92K

$142.5K

How much do downstream process engineer jobs pay per year?

As of May 31, 2026, the average yearly pay for downstream process engineer in the United States is $92,018.00, according to ZipRecruiter salary data. Most workers in this role earn between $74,500.00 and $103,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, experience with purification processes, and often a relevant engineering degree. Familiarity with chromatography, filtration systems, process simulation software (like Aspen or MATLAB), and cGMP regulations is typically required. Strong problem-solving, analytical thinking, and communication skills enable effective troubleshooting and collaboration with cross-functional teams. These skills are crucial for optimizing product yield, ensuring regulatory compliance, and maintaining efficient and safe manufacturing operations.

What are some common challenges faced by Downstream Process Engineers when scaling up bioprocesses from lab to production?

One of the key challenges for Downstream Process Engineers is ensuring that purification and separation processes developed at the lab scale remain efficient and cost-effective during large-scale production. Factors such as changes in equipment performance, increased impurity loads, and process consistency can complicate scale-up. Engineers must also collaborate closely with upstream teams, quality assurance, and manufacturing staff to troubleshoot issues and optimize yield and product quality. Effective communication and adaptability are essential for overcoming these challenges and ensuring a smooth transition from development to manufacturing.

What is a Downstream Process Engineer?

A Downstream Process Engineer is a professional who specializes in the purification and processing of biological products, such as proteins or pharmaceuticals, after the initial production phase. Their main responsibility is to develop, optimize, and manage processes that separate and refine products from mixtures, ensuring quality and efficiency. This typically involves techniques like filtration, chromatography, and centrifugation. Downstream Process Engineers work closely with other scientists and engineers to scale up processes for commercial manufacturing while maintaining safety and regulatory compliance.

What is the difference between Downstream Process Engineer vs Upstream Process Engineer?

AspectDownstream Process EngineerUpstream Process Engineer
Primary FocusPurification, separation, and finishing of bioproductsCell culture, fermentation, and biomass production
Skills & CertificationsBioprocessing, chromatography, filtration, GMP knowledgeBioreactor operation, microbiology, fermentation techniques
Work EnvironmentManufacturing facilities, labs, quality controlResearch labs, pilot plants, production facilities
Industry UsageBiotech, pharmaceutical manufacturingBiotech, pharmaceutical, agricultural biotech

Both roles are essential in bioprocessing, with downstream process engineers focusing on product purification and upstream process engineers on initial bioproduction. Understanding their differences helps in career planning and job search strategies within the biotech industry.

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What job categories do people searching Downstream Process Engineer jobs look for? The top searched job categories for Downstream Process Engineer jobs are:
Downstream Process Engineer jobs near you
Infographic showing various Downstream Process Engineer job openings in the United States as of May 2026, with employment types broken down into 33% Full Time, and 67% Contract. Highlights an 100% In-person job distribution, with an average salary of $92,018 per year, or $44.2 per hour.

Downstream Process Equipment Engineer

Technical Source

Holly Springs, NC

Contractor

Posted 25 days ago

Job description

Technical Source is currently in search of a Downstream Process Equipment Engineer for our pharmaceutical client in the Raleigh-Durham-Chapel Hill Area. This is a long-term contract position that requires on-site work. The qualified candidate should have experience supporting the start-up and commissioning of downstream process equipment.

Responsibilities of the Downstream Process Equipment Engineer include:

  • Provide Engineering Support to C&Q of Downstream Equipment
  • Troubleshoot Downstream Manufacturing Equipment
  • Initiate CAPA's and Change Controls
  • Lead Process Improvement Efforts

Qualifications of the Downstream Equipment Process Engineer include:

  • Bachelor's Degree in Engineering (Chemical Preferred)
  • 3+ Years of Experience in Process Engineering
  • Experience Working in a Greenfield Environment
  • Extensive Knowledge of Stainless Steel Downstream Equipment