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Downstream Process Jobs in Worcester, MA (NOW HIRING)

AT Process Technologies

Process Chemist

Waltham, MA · On-site

$130K - $200K/yr

Develop and optimize core synthesis and downstream processing, evaluating competing technical pathways and justifying key decisions using experimental results, process modeling, cost, and scale-up ...

Integrated Resources INC

Biprocess Engineer

Devens, MA · On-site

The successful candidate will have a demonstrated background in bioprocessing (upstream and/or downstream), experience troubleshooting manufacturing processes and strong technical documentation ...

Sartorius AG

Process Technology Engineer

Marlborough, MA · On-site

$95K - $120K/yr

Join Sartorius as a Process Technology Engineer, supporting upstream and downstream bioprocess solutions across the full project lifecycle-from customer discovery through project execution. You will ...

Repligen Corporation

Scientist II

Waltham, MA · On-site

• The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

Repligen

Scientist II

Waltham, MA · On-site

The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

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Downstream Process information

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$13

$24

$35

How much do downstream process jobs pay per hour?

As of Aug 13, 2026, the average hourly pay for downstream process in Worcester, MA is $24.62, according to ZipRecruiter salary data. Most workers in this role earn between $19.66 and $28.08 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are popular job titles related to Downstream Process jobs in Worcester, MA?

For Downstream Process jobs in Worcester, MA, the most frequently searched job titles are:

What job categories do people searching Downstream Process jobs in Worcester, MA look for?

The top searched job categories for Downstream Process jobs in Worcester, MA are:

What cities near Worcester, MA are hiring for Downstream Process jobs?

Cities near Worcester, MA with the most Downstream Process job openings:

Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Worcester, MA as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 17% Part Time, 3% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $51,207 per year, or $24.6 per hour.

Process Engineer - Upstream/Downstream

Integrated Resources INC

Devens, MA • On-site

Contractor

Re-posted 25 days ago

Job description

Company Description

Client is a global bio-pharmaceutical company

Job Description

The successful candidate will provide meaningful contributions toward commercial manufacturing support, process monitoring, technology transfer and process validation activities. The successful candidate will have a demonstrated background in bioprocessing (upstream and/or downstream), experience troubleshooting manufacturing processes and strong technical documentation skills (memos, protocols, reports).

Responsibilities:

Work independently to provide commercial manufacturing technical support, process monitoring, technology transfer and process validation activities for downstream processes.

Provide process troubleshooting during scale-up and routine manufacturing.

Provide process subject matter expertise and ownership of assigned deliverables.

The successful candidate will work effectively in highly cross-functional project teams, matrix management environments, as well as independent working environments to support the site.

Perform data analysis and monitoring for process performance and product quality outputs.

The position will interface with Manufacturing, Quality, Engineering, and internal MS&T departments at multiple sites throughout the Client network

Strong communication and technical writing skills are required.

Qualifications

B.S./M.S. or Ph.D. in Chemical Engineer, Biochemical Engineer, Biomedical Engineer, Biochemistry or related field (Advanced degree is preferred)

Required: Prior experience (Ph.D: 0 - 2 years; BS/MS: 2 - 6 years) in process development, process validation or manufacturing support in bioprocessing (upstream and/or downstream)

Preferred: Prior experience scaling up biopharma manufacturing processes (upstream/downstream), facility fit assessments, process scale-up from bench/pilot to production, process troubleshooting and optimization, and process validation.

Hands-on experience working with chromatography, ultrafiltration and depth filtration process acquired through lab, pilot or production scale experience.

Preferred: Experience performing manufacturing investigations for biologics manufacturing.

Preferred: Experience providing start-up support for new biologics manufacturing processes (Person-In-Plant)

Preferred: Experience with statistical methodologies (DOE, SPC, etc), cGMP regulations, and regulatory requirements is expected.

Additional Information

All your information will be kept confidential according to EEO guidelines.

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About Integrated Resources

Sourced by ZipRecruiter

Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.

Industry

Recruiting and staffing services

Company size

51 - 200 Employees

Headquarters location

Edison, NJ, US

Year founded

1996

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