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Downstream Process Jobs in Boston, MA (NOW HIRING)

Managed Staffing

Purification Scientist

Boston, MA · On-site

$44 - $46/hr

Monday-Friday | 8:00 AM-5:00 PM (40 hrs/week Position Summary Seeking an early-career Biologist / Purification Scientist to join the Downstream Process Development team in Boston, MA. This role will ...

Valspec

Validation Engineer (CQV)

Boston, MA

This role will focus on downstream process systems and requires strong hands-on field execution, system troubleshooting, and automation verification experience in a GMP-regulated environment. Key ...

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Downstream Process information

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How much do downstream process jobs pay per hour?

As of Jul 17, 2026, the average hourly pay for downstream process in Boston, MA is $26.80, according to ZipRecruiter salary data. Most workers in this role earn between $21.39 and $30.58 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Boston, MA? For Downstream Process jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Boston, MA look for? The top searched job categories for Downstream Process jobs in Boston, MA are:
What cities near Boston, MA are hiring for Downstream Process jobs? Cities near Boston, MA with the most Downstream Process job openings:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Boston, MA as of July 2026, with employment types broken down into 18% Locum Tenens, 71% Full Time, 7% Part Time, 3% Contract, and 1% Summer. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $55,753 per year, or $26.8 per hour.

Process Manager - Downstream Process Development

Rentschler

Milford, MA • On-site

Full-time

Medical, Retirement

Re-posted 3 days ago

Job description

Advancing medicine to save lives. Together.
Thanks to many decades of experience and our passion for what we do, we make an essential contribution to the global availability of biopharmaceuticals, especially for patients with rare and serious diseases.
Rentschler Biopharma SE is a leading contract development and manufacturing organization (CDMO) focused exclusively on client projects. We offer customized full-service solutions for bioprocess development and the production of complex biopharmaceuticals. As a German family-owned company with an international footprint and global reach, we combine experts, expertise and years of experience to develop best-in-class solutions - together with our clients.
Rentschler Biopharma has approximately 1,400 employees and is headquartered in Laupheim, Germany, with a site in Milford, MA, USA. In 2024, we joined the United Nations Global Compact, underlining our commitment to sustainability.
As an independent family-owned company, we live by the motto: Many hands, many minds - ONE TEAM! Open, respectful cooperation characterizes our working environment, where quality awareness, diligence and responsibility are our top priorities. With all the diversity of our talents in the Rentschler team, we pursue one vision together: advancing medicine to save lives.
We are seeking a proactive, strategic, and hands-on DSP Process Manager. They will demonstrate flexibility, adaptability, and can effectively work in a fast paced, rapidly changing CDMO environment. They are self-motivated, accountable, inquisitive, and have excellent organizational and communication skills. They can multi-task while delivering excellent customer service.
The Process Manager in the Downstream Process Development group is a functional project(s) lead, who independently designs, executes, and support biologics downstream purification processes including technology transfer activities both from the client(s) and internally to the GMP manufacturing facility.
Duties and Responsibilities
  • Develop scale-able and robust downstream processes for clinical and commercial GMP manufacturing.
    • Design experiments related to development, optimization, scale-up of all steps of various recombinant protein formats (e.g., antibodies, bispecific and enzymes) inclusive of viral clearance studies.
    • Lead lab team members in the execution of experiments.
    • Apply DoE and other advanced statistical techniques to design and evaluate late-stage development activities and process characterization studies in preparation for process qualification and validation at manufacturing scale.
    • Define the control strategy for commercial manufacturing.
  • Interface with clients.
    • Analyze, prepare, and formally present data.
    • Author and collaborate on client-approved documents.
    • Provide technical consulting as a Subject Matter Expert.
  • Transfer programs to Manufacturing.
    • Provide process descriptions and gap analyses.
    • Collaborate with MSAT on change controls, deviations, and investigations.
    • Support Manufacturing and MSAT as process Subject Matter Expert, including on floor support.
  • Author high-quality documents.
    • Experimental protocols, technical reports, risk/gap assessments, SOPs, and facility fit assessments.
    • Assist with and review relevant chapters of CMC dossier sections for IND/IMPD and BLA/MAA.
    • Process and Subject Matter Expert review on batch records.
  • Lead, train, and mentor junior lab staff.
  • Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding.
    • Contribute to the overall operations of process sciences lab and infrastructure improvements.
  • Active contributor/connector on harmonization and alliance of concepts, procedures, techniques, and documentation within international sites of the company
  • Serve as Process Science representative and participate in cross functional meetings.

Qualifications
  • Years of experience and education (one of the following):
  • A university degree and 5-8+ years of related experience
  • A Master's degree and 3-5+ years
  • A PhD and 1-3+ years of experience
  • Expertise in chromatographic processes, filtration techniques, protein chemistry, and associated analytical methods
  • Expertise in scale-up/scale-down principles as well as the use of statistical tools for data analysis and DoE
  • Experience in process characterization, qualification/validation (PPQ) and/or continued process verification (CPV) is preferred
  • Experience in viral clearance validation and scale down validation is preferred
  • Advanced proficiency with required software - Unicorn, JMP/MODDE, Word, Excel, PowerPoint
  • The candidate must demonstrate critical thinking, be self-motivated, accountable, inquisitive, have excellent organization and communication skills, and demonstrates the ability to work both independently and as a member of local and global teams
  • Excellent customer service skills and ability to meet client project deadlines
  • Basic knowledge of project management
  • Flexibility of hours to support process development or MFG floor activities over weekends and holidays; weekend and holiday hours are compensated per company policies
  • Flexibility to switch between projects

Working Conditions
  • Laboratory and manufacturing clean-room environments working with chemical reagents and processing equipment
  • Compliance with Personal Protective Equipment, clean room gowning, and EH&S requirements
  • Normal office working conditions: computer, phone, files, printer, etc
  • Interaction with people in the lab, other departments, and clients
  • Fast-paced environment with job completion deadlines

Physical Requirements
  • Frequent lifting up to 10 lbs
  • Sitting for extended periods for computer-based work
  • Standing/walking to work in lab environment for extended periods

Base Pay Range
$120,000 - $145,000
Disclosure Statement
Rentschler Biopharma, Inc is committed to fair and equitable compensation practices. The base pay range listed for this position is the anticipated annual base salary range the organization reasonably, and in good faith, expects to pay for this position at this time. Actual compensation is determined based on several factors that may include seniority, education, training, relevant experience, relevant certifications, geography of work location, job responsibilities, or other application factors permissible by law. The annual base salary is just one component of our Total Rewards package, which also includes our annual discretionary bonus program, medical insurance, our generous 401K program, plus a host of other benefits to aligned to support our employees' personal and professional wellness. The salary pay range is subject to change and may be modified at any time.

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