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Downstream Process Jobs in Boston, MA (NOW HIRING)

Sartorius AG

Process Technology Engineer

Marlborough, MA · On-site

$95K - $120K/yr

Join Sartorius as a Process Technology Engineer, supporting upstream and downstream bioprocess solutions across the full project lifecycle-from customer discovery through project execution. You will ...

CEDENT

Senior Scientist, Process Development

Watertown, MA · On-site

$99K - $135K/yr

We are seeking a Senior Scientist, Process Development, responsible for executing cell culture experiments, downstream processing, analyzing data, and contributing to process development projects.

Merck Group

Senior Bioprocess Engineer

Burlington, MA · On-site

$113K - $156K/yr

Drawing on your deep expertise in downstream processing, you will monitor industry trends, engage with the scientific community, and represent the organization at conferences to stay at the forefront ...

Repligen Corporation

Scientist II

Waltham, MA · On-site

• The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

Repligen

Scientist II

Waltham, MA · On-site

The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

Zealand Pharma

Global Head of Drug Substance

Cambridge, MA · On-site

$251K - $307K/yr

Develop and optimize upstream and downstream process design to establish scalable, cost-effective synthetic routes fit for initial clinical trials and as the foundation for Phase 3 * Partner closely ...

Zealand Pharma

Global Head of Drug Substance

Cambridge, MA · On-site

$251K - $307K/yr

Develop and optimize upstream and downstream process design to establish scalable, cost-effective synthetic routes fit for initial clinical trials and as the foundation for Phase 3 * Partner closely ...

Zealandpharma

Global Head of Drug Substance

Cambridge, MA · On-site

$251K - $307K/yr

Develop and optimize upstream and downstream process design to establish scalable, cost-effective synthetic routes fit for initial clinical trials and as the foundation for Phase 3 * Partner closely ...

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Showing results 21-40

All JobsDownstream Process JobsDownstream Process Jobs in Boston, MA

Downstream Process information

See Boston, MA salary details

$14

$26

$38

How much do downstream process jobs pay per hour?

As of Sep 3, 2026, the average hourly pay for downstream process in Boston, MA is $26.80, according to ZipRecruiter salary data. Most workers in this role earn between $21.39 and $30.58 per hour, depending on experience, location, and employer.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Boston, MA?

For Downstream Process jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Downstream Process jobs in Boston, MA look for?

The top searched job categories for Downstream Process jobs in Boston, MA are:

What cities near Boston, MA are hiring for Downstream Process jobs?

Cities near Boston, MA with the most Downstream Process job openings:

Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $55,753 per year, or $26.8 per hour.

Purification Scientist - Biologics / Viral Vectors

Managed Staffing

Boston, MA • On-site

$45 - $46/hr

Contractor

Re-posted 28 days ago

Job description

Job Title: Biologist
Location: Boston, MA 02210
Work Schedule: Monday–Friday, 8:00 AM – 5:00 PM

Job Overview:

We are seeking a highly motivated Biologist to join our Downstream Process Development team. The candidate will contribute to the purification and characterization of viral vectors, biologics, or recombinant proteins, supporting process development and manufacturing activities.

Key Responsibilities:

  • Execute purification processes including affinity chromatography (e.g., AVB, CaptureSelect) and ion-exchange chromatography (AEX, CEX).

  • Operate AKTA systems (Avant, Pure, or Pilot) for small- to large-scale purification runs.

  • Perform tangential flow filtration (TFF) for buffer exchange and product concentration.

  • Support experimental design, data collection, and documentation following GMP/GLP guidelines.

  • Troubleshoot and optimize purification processes.

  • Analyze samples using relevant methods (UV, SDS-PAGE, ddPCR, ELISA, HPLC).

  • Collaborate cross-functionally with upstream, analytical, and manufacturing teams.

  • Maintain lab equipment, buffers, column inventory, and compliance with safety standards.

Qualifications:

Education:

  • Master’s degree in Biochemistry, Chemical Engineering, Biotechnology, or related field.

Experience:

  • Minimum 2 years of hands-on purification experience in academic or industry settings.

Technical Skills:

  • Strong experience with ion-exchange and affinity chromatography.

  • Familiarity with buffer preparation.

  • Knowledge of basic analytical methods for product characterization.

Soft Skills:

  • Strong attention to detail and excellent documentation habits.

  • Effective communication and teamwork skills.

  • Ability to manage multiple tasks and meet project timelines.

Preferred Qualifications:

  • Experience in AAV or other viral vector purification.

  • Experience with AKTA systems and Unicorn software.