ZipRecruiter

Log In

1

Downstream Process Jobs in Boston, MA (NOW HIRING)

Emergent Biosolutions

BioProcess Specialist

Canton, MA · On-site

Provide hands-on technical leadership and GMP support to vaccine drug substance manufacturing operations, acting as a trusted SME for upstream, downstream, and/or bulk formulation processes. * Lead ...

Syner-G

Process Engineer

Plainville, MA · On-site

Strong understanding of upstream, downstream, fill-finish, or related manufacturing processes. * Hands-on experience with single-use systems (SUS) design, implementation, and operational support.

previous page

Showing results 41-60

All JobsDownstream Process JobsDownstream Process Jobs in Boston, MA

Downstream Process information

See Boston, MA salary details

$14

$26

$38

How much do downstream process jobs pay per hour?

As of Aug 11, 2026, the average hourly pay for downstream process in Boston, MA is $26.80, according to ZipRecruiter salary data. Most workers in this role earn between $21.39 and $30.58 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Boston, MA? For Downstream Process jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Boston, MA look for? The top searched job categories for Downstream Process jobs in Boston, MA are:
What cities near Boston, MA are hiring for Downstream Process jobs? Cities near Boston, MA with the most Downstream Process job openings:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $55,753 per year, or $26.8 per hour.

BioProcess Specialist

Emergent Biosolutions

Canton, MA • On-site

Full-time

Medical, Vision

Re-posted 18 days ago

Job description

Preparedness today, safer tomorrow.
Emergent is a leading public health company that delivers protective and life-saving solutions to
communities around the world. Here, you will join passionate professionals where our culture is informed
by our values and commitment to protecting and saving lives.
JOB SUMMARY
The Bioprocess Specialist is a senior individual contributor providing advanced technical and operational support to GMP vaccine drug substance manufacturing operations at the Canton, MA site. This role serves as a manufacturing subject matter expert (SME), partnering closely with Manufacturing, Quality, MSAT, Engineering, and external stakeholders to ensure robust, compliant, and efficient bioprocess execution. The incumbent plays a critical role in process performance monitoring, QMS execution (deviations, CAPAs, change control), continuous improvement, and regulatory readiness, with a strong focus on product quality, patient safety, and inspection success.
ESSENTIAL FUNCTIONS
Reasonable accommodations will be made to enable individuals with disabilities to perform the essential functions.
  • Provide hands-on technical leadership and GMP support to vaccine drug substance manufacturing operations, acting as a trusted SME for upstream, downstream, and/or bulk formulation processes.
  • Lead and support complex investigations (process- and product-impacting deviations), author high-quality investigation reports, root cause analyses, and ensure timely, effective, and sustainable CAPAs.
  • Own and support Change Management activities, including technical assessments, risk evaluations, implementation oversight, and change effectiveness verification.
  • Drive process robustness and continuous improvement through data trending, root cause analysis, risk assessments, and application of process understanding and scientific principles.
  • Collaborate cross-functionally with Manufacturing, Quality Assurance, MSAT, Validation, Supply Chain, and Engineering to resolve complex technical and compliance issues.
  • Serve as a key contributor to regulatory inspection readiness activities, including document preparation, response development, and participation in health authority inspections.
  • Support process lifecycle activities including technology transfer, process characterization, process validation, and ongoing process verification, as applicable to a GMP vaccine DS site.
  • Develop and maintain GMP documentation, including SOPs, batch records, protocols, and technical reports, ensuring accuracy, clarity, and compliance with regulatory expectations.
  • Mentor manufacturing and technical staff by sharing expertise in bioprocessing, GMP principles, and quality systems, enhancing organizational capability and knowledge depth.
  • Identify, implement, and sustain best practices, digital tools, and operational excellence initiatives aligned with site and network strategies.
  • Engage internal and external stakeholders, including vendors and partners, to support troubleshooting, continuous improvement, and execution of technical projects.

The above statements are intended to describe the nature of work performed by those in this job and are not an exhaustive list of all duties. Nothing in this job description restricts managements right to assign or reassign duties and responsibilities to this job at any time which reflects management's assignment of essential functions.
MINIMUM EDUCATION, EXPERIENCE, SKILLS
Due to the nature of this role and our manufacturing environment, employees are required to meet certain health and safety requirements, including the ability to adhere to the Company's vaccination policies where job-related and consistent with applicable law. We are committed to providing a fair and inclusive hiring process and will evaluate reasonable accommodation requests for medical disabilities, or sincerely held religious beliefs, in accordance with applicable laws.
  • Bachelor's degree in Chemical Engineering, Biochemical Engineering, Biotechnology, Biochemistry, Biology, or a related scientific discipline is required; Master's degree is preferred.
  • Minimum of 5-8 years of progressively responsible experience in GMP biopharmaceutical manufacturing, with strong preference for vaccine drug substance or biologics bulk manufacturing.
  • Demonstrated expertise in GMP quality systems, including deviations, CAPAs, change control, risk management, and inspection readiness.
  • Strong technical understanding of bioprocess unit operations (upstream and/or downstream), process control strategies, and manufacturing science.
  • Proven ability to lead and influence cross-functional teams without direct authority in a matrixed organization.
  • Experience authoring and reviewing GMP documentation, investigations, technical reports, and regulatory-facing content.
  • Solid data analysis, problem-solving, and critical thinking skills, with the ability to apply scientific and risk-based approaches to complex issues.
  • Excellent written and verbal communication skills, with the ability to present technical information clearly to diverse audiences.
  • High level of accountability, sound judgment, and quality mindset, with a demonstrated commitment to compliance and continuous improvement.

If the hiring manager expresses an interest in interviewing you for the open position, you must discuss your interest in the open position with your current manager prior to an interview being scheduled.
U.S. Base Pay Ranges and Benefits Information
The estimated annual base salary as a new hire for this position ranges from $111,000 to $130,500. Individual base pay depends on various factors such as applicant's education, experience, skills, and abilities, as well as internal equity and alignment with market data. The salary may also be adjusted based on applicant's geographic location. Certain roles are eligible for additional incentive compensation, including merit increases, annual bonus, [and/or long-term incentives in the form of stock options.]
Additionally, Emergent offers a comprehensive benefits package*. Information regarding additional benefits can be found here: https://www.emergentbiosolutions.com/careers/life-at-emergent
(*Eligibility for benefits is governed by the applicable plan documents and policies).
If you are selected for an interview, please feel welcome to speak to a Human Resources Partner about our compensation philosophy and available benefits.
ABOUT EMERGENT
Emergent prepares those entrusted with protecting their communities against current and future health threats.
Our drive towards this vision informs all of our actions-whether it is our approach to product development, manufacturing, encouraging employee health and wellness or giving back to the community-we strive every day to achieve this shared goal.
WE BELIEVE IN OUR VALUES
  • Lead with Integrity
    • We gain trust and confidence through ethics, quality, and compliance excellence
  • Stand shoulder to shoulder
    • We combine our best thinking and communicate openly to support each other.
  • Own it always
    • We are engaged and accountable for delivering on our commitments.
  • Breakthrough thinking
    • We take smart risks, pursue innovation and challenge ourselves to constantly improve.
  • Compete where it counts
    • We set the right goals and respect each other as we conquer them together.

Apply