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Downstream Process Jobs in Boston, MA (NOW HIRING)

Emergent Biosolutions

Sr Engineer, Process

Canton, MA · On-site

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

Emergent Biosolutions

Sr Engineer, Process

Canton, MA · On-site

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

Emergent Biosolutions

Sr Engineer, Process

Canton, MA · On-site

$110K - $142K/yr

This role provides hands-on process engineering support to ensure safe, reliable, and compliant manufacturing across upstream and downstream operations. The Senior Process Engineer is accountable for ...

Emergent Biosolutions

BioProcess Specialist

Canton, MA · On-site

Provide hands-on technical leadership and GMP support to vaccine drug substance manufacturing operations, acting as a trusted SME for upstream, downstream, and/or bulk formulation processes. * Lead ...

Emergent Biosolutions

BioProcess Specialist

Canton, MA · On-site

Provide hands-on technical leadership and GMP support to vaccine drug substance manufacturing operations, acting as a trusted SME for upstream, downstream, and/or bulk formulation processes. * Lead ...

Emergent Biosolutions

BioProcess Specialist

Canton, MA · On-site

Provide hands-on technical leadership and GMP support to vaccine drug substance manufacturing operations, acting as a trusted SME for upstream, downstream, and/or bulk formulation processes. * Lead ...

Amgen

Process Development Associate

Cambridge, MA · On-site

... and downstream manufacturing processes supporting Ph II/III clinical trials to marketing ... application. This role is within an integrated organization in which cell culture and purification ...

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All JobsDownstream Process JobsDownstream Process Jobs in Boston, MA

Downstream Process information

See Boston, MA salary details

$14

$26

$38

How much do downstream process jobs pay per hour?

As of Sep 2, 2026, the average hourly pay for downstream process in Boston, MA is $26.80, according to ZipRecruiter salary data. Most workers in this role earn between $21.39 and $30.58 per hour, depending on experience, location, and employer.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Boston, MA?

For Downstream Process jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Downstream Process jobs in Boston, MA look for?

The top searched job categories for Downstream Process jobs in Boston, MA are:

What cities near Boston, MA are hiring for Downstream Process jobs?

Cities near Boston, MA with the most Downstream Process job openings:

Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Boston, MA as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $55,753 per year, or $26.8 per hour.

Downstream Manufacturing Associate III - 3rd Shift

JMD Technologies Inc.

Milford, MA • On-site

$35 - $44/hr

Other

Posted 4 days ago

Job description

Title: Downstream Manufacturing Associate III

Location: Milford, MA (Onsite, 3rd Shift)

Employment Type: Contract, 6+ Months

Status: Accepting Candidates

About the Role

Support GMP downstream manufacturing operations for clinical, development, validation, and commercial-scale activities, serving as a technical resource for purification processes, equipment operation, troubleshooting, and team training.

Key Responsibilities

  • Execute downstream manufacturing operations involving tangential flow filtration (TFF), chromatography, monoclonal antibody (mAb) purification, and disposable technologies.
  • Operate and troubleshoot manufacturing equipment and systems, including ÄKTA systems, XDUO buffer systems, process tanks, chromatography skids and columns, and related production equipment.
  • Monitor and document batch parameters, complete GMP/GDP documentation, perform calculations, and support deviations, investigations, event management, and batch-record revisions.
  • Train and oversee newer operators, serve as a subject matter expert, and support cross-functional teams and manufacturing stakeholders.
  • Lead or contribute to continuous improvement initiatives and process improvements while maintaining cleanroom, safety, and production requirements.

Qualifications

  • High school diploma with 6+ years of related experience, an associate degree in Life Sciences/Engineering with relevant experience, or a bachelor's degree with 4+ years of related experience; biotech certification preferred.
  • Demonstrated experience in cGMP downstream manufacturing, particularly TFF, chromatography, and mAb purification.
  • Experience operating and troubleshooting laboratory and pharmaceutical production equipment and applying structured problem-solving/root-cause analysis.
  • Strong technical documentation, communication, computer, and Microsoft Word/Excel skills, with the ability to author procedures and complete GMP records accurately.
  • Ability to work effectively in a cleanroom environment, follow hygiene and PPE requirements, and work the required overnight schedule, including weekends, holidays, and overtime as needed.

Compensation:

  • $35–$44/hr + 20% shift differential.
  • Final compensation within the posted range will depend on qualifications, experience, and interview results.


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