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Downstream Process Jobs in Worcester, MA (NOW HIRING)

Boston Dynamics

Staff Sales Support Specialist

Waltham, MA · On-site

$80K - $100K/yr

... downstream rework. * Ensure clean handoff of orders to Finance, Legal, and Fulfillment teams. * Process Discipline & Lead-to-Cash Support * Operate within defined lead-to-cash processes, executing ...

Bostondynamics

Staff Sales Support Specialist

Waltham, MA · On-site

$80K - $100K/yr

... downstream rework. * Ensure clean handoff of orders to Finance, Legal, and Fulfillment teams. * Process Discipline & Lead-to-Cash Support * Operate within defined lead-to-cash processes, executing ...

Repligen

Sr. Associate Scientist

Marlborough, MA · On-site

The Sr. Associate Scientist is a hands-on R&D role focused on the development and evaluation of membrane-based separation technologies for downstream bio-processing, with an emphasis on ...

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All JobsDownstream Process JobsDownstream Process Jobs in Worcester, MA

Downstream Process information

See Worcester, MA salary details

$13

$24

$35

How much do downstream process jobs pay per hour?

As of Aug 7, 2026, the average hourly pay for downstream process in Worcester, MA is $24.62, according to ZipRecruiter salary data. Most workers in this role earn between $19.66 and $28.08 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
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What job categories do people searching Downstream Process jobs in Worcester, MA look for? The top searched job categories for Downstream Process jobs in Worcester, MA are:
What cities near Worcester, MA are hiring for Downstream Process jobs? Cities near Worcester, MA with the most Downstream Process job openings:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Worcester, MA as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $51,207 per year, or $24.6 per hour.

Research Associate/Sr. Research Associate- Strain and Enzyme Engineering

Manus

Waltham, MA

Full-time

Posted 28 days ago

Job description

Research Associate / Senior Research Associate – Strain and Enzyme Engineering-Waltham, MA

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of biotechnology today.

Manus is seeking a Research Associate (RA) or Senior Research Associate (SRA) to support strain engineering and analytics workflows within our project pipeline. In this role, you will design and construct plasmids, generate chromosomally integrated Escherichia coli (E. coli) strains, culture and screen engineered strains, and process the resulting analytical data (liquid extraction, Gas Chromatography (GC) and/or Liquid Chromatography (LC)) to identify strains with enhanced performance. This role focuses on execution of defined engineering campaigns to drive meaningful improvements in a fast-paced, cross-functional environment.

This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative. This person will be expected to play an integral part of Manus’s research and development team located in Waltham, Massachusetts (MA).

Responsibilities

Molecular biology: Design, construct, and validate plasmids for gene expression and pathway engineering in microbial hosts.

Strain construction: Generate chromosomally integrated E. coli strains (e.g., via recombineering or CRISPR-based methods) to support strain engineering campaigns.

Strain cultivation: Culture and maintain engineered E. coli strains in solid and liquid formats at lab scale.

Sample preparation: Perform liquid-liquid or solid-phase extraction of fermentation broth and other sample matrices to prepare samples for analytical testing.

Analytical execution: Operate GC and/or LC instrumentation to generate quantitative data on strain performance (e.g., titer, yield, product profile).

Data analysis: Process, QC, and interpret analytical and strain-performance data; summarize and present findings to the project team.

Data management: Ensure accurate data collection, processing, and upload to LIMS systems.

Collaboration: Collaborate with cross-functional teams (molecular biology, fermentation, downstream processing) to improve experimental outcomes.

Lab operations: Maintain instrumentation readiness and general lab organization.

Documentation: Author and update SOPs and experimental documentation.

Basic Qualifications

  • Research Associate: Bachelor’s degree with 0–4 years’ relevant experience.
  • Senior Research Associate: Bachelors with 4–7 years’ or master’s with 2–4 years’ relevant experience.
  • Degree in molecular biology, biochemistry, microbiology, chemistry, bioengineering, or a related field (field of degree is flexible; relevant hands-on experience is prioritized).
  • Hands-on experience with plasmid design and cloning (e.g., Gibson assembly, Golden Gate, restriction/ligation).
  • Experience culturing and screening engineered microbial strains in liquid and/or solid formats.

Preferred Skills

  • Direct experience generating chromosomal integrations in E. coli specifically (e.g., lambda Red recombineering, CRISPR-based integration).
  • Experience with LIMS systems (e.g., Benchling).
  • Data analysis and visualization experience (e.g., JMP, Python, SQL).
  • Familiarity with GC-MS or LC/MS (mass-selective detection) in addition to GC-FID or standard LC/UV-Vis workflows.
  • Experience with sample extraction (liquid-liquid or solid-phase) from biological or fermentation matrices.
  • Experience with automated liquid-handling systems.

Physical Requirements

  • Ability to work in industrial environments.
  • May require standing, walking, climbing stairs, and lifting equipment up to 50 lbs.
  • Use of PPE required in designated areas.