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Downstream Process Jobs in Worcester, MA (NOW HIRING)

Danaher

Filtration Sales Specialist

Marlborough, MA · Remote

$100K - $130K/yr

Bachelor's degree in life sciences or relevant field * 2+ plus years of hands-on experience with filtration and downstream processing preferred * Strong communication skills - English written and ...

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Downstream Process information

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$13

$24

$35

How much do downstream process jobs pay per hour?

As of Sep 2, 2026, the average hourly pay for downstream process in Worcester, MA is $24.62, according to ZipRecruiter salary data. Most workers in this role earn between $19.66 and $28.08 per hour, depending on experience, location, and employer.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Worcester, MA?

For Downstream Process jobs in Worcester, MA, the most frequently searched job titles are:

What job categories do people searching Downstream Process jobs in Worcester, MA look for?

The top searched job categories for Downstream Process jobs in Worcester, MA are:

What cities near Worcester, MA are hiring for Downstream Process jobs?

Cities near Worcester, MA with the most Downstream Process job openings:

Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Worcester, MA as of August 2026, with employment types broken down into 1% As Needed, 77% Full Time, 17% Part Time, 4% Contract, and 1% Nights. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $51,207 per year, or $24.6 per hour.

Adjunct Instructor - Biomanufacturing

Worcester Polytech

Worcester, MA

$75/hr

Part-time

Re-posted 11 days ago

Job description

JOB TITLE

Adjunct Instructor - Biomanufacturing

LOCATION

Worcester

DEPARTMENT NAME

Biomanufacturing Education and Training Center - BETC - JM

DIVISION NAME

Worcester Polytechnic Institute - WPI

JOB DESCRIPTION SUMMARY

The Biomanufacturing Education & Training Center (BETC) at Worcester Polytechnic Institute (WPI) is seeking to expand its pool of adjunct instructors to support hands-on training programs in its state-of-the-art, pilot-scale mammalian biomanufacturing facility.
BETC is the first center in New England to offer intensive, immersive education and workforce training for professionals currently working in the biotechnology and biopharmaceutical industries, as well as individuals seeking to transition into biomanufacturing careers. We are looking for experienced subject matter experts who are passionate about sharing industry knowledge and training the next generation of biomanufacturing talent.

JOB DESCRIPTION

Responsibilities:

Adjunct instructors teach onsite at the BETC facility and facilitate both classroom instruction and hands-on laboratory training. Instructors will guide participants through core concepts and realworld applications across the biomanufacturing workflow.

Specifically, we are seeking subject matter experts in one or more of the following areas:

Upstream Processing of Mammalian (Animal) Cell Cultures

  • Cell culture fundamentals
  • Bioreactor operations
  • Process monitoring and optimization

Downstream Processing Principles and Techniques

  • Harvest, clarification, and purification
  • Chromatography and filtration
  • Process understanding within a GMP framework

Instructional assignments are flexible and may include teaching in a specific technical area or across multiple modules, depending on expertise. Evening and flexible scheduling options are available to accommodate industry professionals.

Requirements:

  • Minimum of 5 years of professional experience working in the bioprocessing or biomanufacturing industry
  • Demonstrated ability to operate laboratory and bioprocessing equipment in a simulated GMP manufacturing environment
  • Prior teaching, training, or on-the-job mentoring experience preferred
  • Strong organizational, communication, and interpersonal skills
  • Ability to effectively engage adult learners with diverse professional backgrounds

Additional Details:

  • This is a part-time, on-site adjunct teaching opportunity (contracted position)
  • All instruction is conducted onsite at the BETC facility
  • Course schedules are offered throughout the year and can be designed to align with instructor availability

To Apply:

Please attach a resume for consideration.

Compensation:

This position pays $75 per hour + depending on experience

FLSA STATUS

United States of America (Exempt)

WPI is an Equal Opportunity Employer. All qualified candidates will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, veteran status,or disability. It seeks individuals from all backgrounds and experiences who will contribute to a culture of creativity, collaboration, inclusion, problem solving, innovation, high performance, and change making.It is committed to maintaining a campus environment free of harassment and discrimination.

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