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Downstream Process Jobs in Illinois (NOW HIRING)

Messina Talent Advisors

Be Seen First

Sr. Chemist

Lansing, IL · On-site

$60K - $110K/yr

... downstream process needs for the dispersion. * Engage with raw material and equipment suppliers to stay current on industry advancements, new dispersion technologies, and emerging market trends.

Vistex BKV

Functional Consultant

Hoffman Estates, IL · On-site

$80K - $120K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

Vistex

Technical Consultant

Hoffman Estates, IL

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Technical Consultant

Hoffman Estates, IL · On-site

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex BKV

Functional Consultant

Hoffman Estates, IL

$80K - $120K/yr

Understanding upstream/downstream process impacts (Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

Vistex

Functional Consultant

Hoffman Estates, IL · On-site

$80K - $120K/yr

Understanding upstream/downstream process impacts (Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

Vistex

Functional Consultant

Hoffman Estates, IL · On-site

$80K - $120K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

Vistex BKV

Technical Consultant

Hoffman Estates, IL

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

iProof

Engineer 2, iPROOF

Decatur, IL · On-site

About the Role The Engineer 2 will support microbial fermentation and downstream processes at pilot and demonstration scales while driving process robustness, manufacturing readiness, technology ...

Vistex BKV

Technical Consultant

Hoffman Estates, IL · On-site

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Technical Consultant

Hoffman Estates, IL · On-site

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Functional Consultant

Hoffman Estates, IL · On-site

$80K - $120K/yr

Understanding upstream/downstream process impacts (Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

Vistex

Technical Consultant

Hoffman Estates, IL · On-site

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Functional Consultant

Hoffman Estates, IL · On-site

$80K - $120K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

SCHUTZ CONTAINER SYSTEMS INC GROUP

Trouble shoots molding processes, monitors part quality and makes adjustments to ensure molding of ... Monitors day to day operation of blow molding machine & downstream equipment. * Performs mold and ...

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Downstream Process information

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Illinois?

For Downstream Process jobs in Illinois, the most frequently searched job titles are:

What job categories do people searching Downstream Process jobs in Illinois look for?

The top searched job categories for Downstream Process jobs in Illinois are:

What cities in Illinois are hiring for Downstream Process jobs?

Cities in Illinois with the most Downstream Process job openings:

Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Illinois as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 13% Part Time, 2% Contract, and 1% Nights. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution.

Manufacturing QMS Specialist

Kashiv BioSciences, LLC

Chicago, IL

Full-time

Medical, Dental, Vision, Retirement

Re-posted 15 days ago

Job description

Description

The Manufacturing QMS Specialist , is a regular employee in a full-time exempt position at Kashiv BioSciences, LLC. This position is located in Chicago, IL. Under the direction of Manufacturing Management, the Manufacturing QMS Specialist will be executing routine documentation work which includes writing and reviewing deviations, change controls, investigation reports, batch records, SOPs, CAPAs etc. This position requires technical expertise in the upstream and downstream process of biologics (Cytokines, monoclonal antibodies manufacturing).


Essential Duties & Responsibilities

  • Will be responsible for supporting the manufacturing team with all kinds of documentation. 
  • Documentation includes reviewing executed batch records (both Upstream department and Downstream batch record). 
  • Will be responsible for filing change controls, Deviation, and CAPA for manufacturing department. 
  • For all critical / major investigation, will have to use investigation tools like 5Why or 6M method.
  • Attend daily meetings with both upstream and downstream process to get all the documentation requirements for the day.
  • Will meet weekly with QA to avoid any delay in the QMS closure.
  • Will author batch records, SOPs and associated forms / formats required for the manufacturing process.
  • Will be responsible for requesting / submitting all GMP documents to QA.
  • During critical campaign, will support manufacturing process (rotating shifts)
  • Wet lab work will not be more than 10 % of your time. 
  • Performs other functions as required or assigned.
  • Complies with all company policies and standards. 

Requirements

Education:

  • A Minimum BA or BS in Biological Sciences or related technical field is required. 
  • Minimum 5 years of experience in Biopharmaceuticals. 
  • Knowledge in USP and DSP process

Special Skills:

  • Ability to work with other team members and independently - good interpersonal skills.
  • Good communication skills: verbal and written, good computer and organization skills, detail oriented.
  • Basic computer skills, including knowledge of Word, Excel and spread sheet
  • Knowledgeable in GMP batch manufacturing and packaging documentation; audit and review.
  • Knowledgeable in cleaning verification/validation. 

Work Environment & Physical Demands:

  • Noise: No extraordinary noise levels.
  • Standing/Lifting: No extraordinary requirements.
  • Visual: No extraordinary requirements.
  • Stress: High-paced demanding environment to meet ambitious project goals.
  • Travel: None


General work environment and physical demands as required to successfully perform the essential functions of this job. Ability to work flexible hours as needed. Ability to work under pressure and meet deadlines. Some travel may be involved.


Supervisory Responsibility, if any: No


Benefits/Perks:

  • Medical
  • Dental
  • Vision
  • 401K
  • FSA 
  • HSA
  • Commuter/Transit Benefits
  • Student Loan Assistance Program
  • Monthly Cell Phone Allowance
  • Free Parking (Company Paid)
  • Conveniently located next to the Metra, Green and Red Line
  • One block east of the Chicago White Sox Stadium
  • < 10 minutes away from Downtown Chicago

This position description is not a complete list of all responsibilities, duties or skill required for the job and is subject to review and change at any time, with or without notice, in accordance with the needs of the organization.


Kashiv Biosciences, LLC provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Kashiv Biosciences, LLC complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, and transfer, leaves of absence, compensation and training.

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