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Downstream Process Jobs in Chicago, IL (NOW HIRING)

Baker Hughes

Sales Sr. Advisor

Chicago, IL · On-site

Are you passionate about driving process technology excellence in downstream refining? Do you enjoy solving complex technical challenges and partnering with customers to optimize refining operations?

Baker Hughes

Sales Sr. Advisor

Chicago, IL · On-site

Are you passionate about driving process technology excellence in downstream refining? Do you enjoy solving complex technical challenges and partnering with customers to optimize refining operations?

Vistex BKV

Functional Consultant

Hoffman Estates, IL

$80K - $120K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

Vistex

Technical Consultant

Hoffman Estates, IL

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Technical Consultant

Hoffman Estates, IL · On-site

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Functional Consultant

Hoffman Estates, IL · On-site

$80K - $120K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

Vistex BKV

Technical Consultant

Hoffman Estates, IL

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex BKV

Technical Consultant

Hoffman Estates, IL

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Technical Consultant

Hoffman Estates, IL · On-site

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Technical Consultant

Hoffman Estates, IL · On-site

$100K - $130K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $100k to $130k ...

Vistex

Functional Consultant

Hoffman Estates, IL · On-site

$80K - $120K/yr

Understanding upstream/downstream process impacts ( Master data, sales, finance, etc.) * Collaboration with offshore teams (internal and external) The compensation for this position is $80k to $120k ...

United Airlines

Data Modeling - SQL Engineer

Chicago, IL · On-site

$118K - $141K/yr

Fetch and process data from Snowflake OneLake and other internal external applications * Extract outputs from applications databases and SQL based systems for downstream processing and analytics

Nippon Paint Holdings Co., Ltd.

Senior Chemist

Lansing, IL · On-site

$57K - $117K/yr

... downstream process needs for the dispersion. * Engage with raw material and equipment suppliers to stay current on industry advancements, new dispersion technologies, and emerging market trends.

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All JobsDownstream Process JobsDownstream Process Jobs in Chicago, IL

Downstream Process information

See Chicago, IL salary details

$13

$25

$36

How much do downstream process jobs pay per hour?

As of Jul 28, 2026, the average hourly pay for downstream process in Chicago, IL is $25.42, according to ZipRecruiter salary data. Most workers in this role earn between $20.29 and $28.99 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Chicago, IL? For Downstream Process jobs in Chicago, IL, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Chicago, IL look for? The top searched job categories for Downstream Process jobs in Chicago, IL are:
What cities near Chicago, IL are hiring for Downstream Process jobs? Cities near Chicago, IL with the most Downstream Process job openings:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Chicago, IL as of July 2026, with employment types broken down into 18% Locum Tenens, 75% Full Time, 4% Part Time, 2% Contract, and 1% Summer. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $52,866 per year, or $25.4 per hour.
Manufacturing QMS Specialist

Manufacturing QMS Specialist

Kashiv Biosciences LLC

Chicago, IL • On-site

Full-time

Medical, Dental, Vision, Retirement

Posted 24 days ago

Job description

Job Type
Full-time
Description
The Manufacturing QMS Specialist , is a regular employee in a full-time exempt position at Kashiv BioSciences, LLC. This position is located in Chicago, IL. Under the direction of Manufacturing Management, the Manufacturing QMS Specialist will be executing routine documentation work which includes writing and reviewing deviations, change controls, investigation reports, batch records, SOPs, CAPAs etc. This position requires technical expertise in the upstream and downstream process of biologics (Cytokines, monoclonal antibodies manufacturing).
Essential Duties & Responsibilities
  • Will be responsible for supporting the manufacturing team with all kinds of documentation.
  • Documentation includes reviewing executed batch records (both Upstream department and Downstream batch record).
  • Will be responsible for filing change controls, Deviation, and CAPA for manufacturing department.
  • For all critical / major investigation, will have to use investigation tools like 5Why or 6M method.
  • Attend daily meetings with both upstream and downstream process to get all the documentation requirements for the day.
  • Will meet weekly with QA to avoid any delay in the QMS closure.
  • Will author batch records, SOPs and associated forms / formats required for the manufacturing process.
  • Will be responsible for requesting / submitting all GMP documents to QA.
  • During critical campaign, will support manufacturing process (rotating shifts)
  • Wet lab work will not be more than 10 % of your time.
  • Performs other functions as required or assigned.
  • Complies with all company policies and standards.

Requirements
Education:
  • A Minimum BA or BS in Biological Sciences or related technical field is required.
  • Minimum 5 years of experience in Biopharmaceuticals.
  • Knowledge in USP and DSP process

Special Skills:
  • Ability to work with other team members and independently - good interpersonal skills.
  • Good communication skills: verbal and written, good computer and organization skills, detail oriented.
  • Basic computer skills, including knowledge of Word, Excel and spread sheet
  • Knowledgeable in GMP batch manufacturing and packaging documentation; audit and review.
  • Knowledgeable in cleaning verification/validation.

Work Environment & Physical Demands:
  • Noise: No extraordinary noise levels.
  • Standing/Lifting: No extraordinary requirements.
  • Visual: No extraordinary requirements.
  • Stress: High-paced demanding environment to meet ambitious project goals.
  • Travel: None

General work environment and physical demands as required to successfully perform the essential functions of this job. Ability to work flexible hours as needed. Ability to work under pressure and meet deadlines. Some travel may be involved.
Supervisory Responsibility, if any : No
Benefits/Perks:
  • Medical
  • Dental
  • Vision
  • 401K
  • FSA
  • HSA
  • Commuter/Transit Benefits
  • Student Loan Assistance Program
  • Monthly Cell Phone Allowance
  • Free Parking (Company Paid)
  • Conveniently located next to the Metra, Green and Red Line
  • One block east of the Chicago White Sox Stadium
  • < 10 minutes away from Downtown Chicago

This position description is not a complete list of all responsibilities, duties or skill required for the job and is subject to review and change at any time, with or without notice, in accordance with the needs of the organization.
Kashiv Biosciences, LLC provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Kashiv Biosciences, LLC complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, and transfer, leaves of absence, compensation and training.

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