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Downstream Process Jobs in Illinois (NOW HIRING)

... downstream engineering disciplines, develop equipment specifications, compile scope of work ... Knowledge of process simulation software (eg Aspen Plus, HYSYS) preferred * Management: Experience ...

Associate Process Engineer

Lisle, IL · On-site

$90K - $130K/yr

Conduct field and technical evaluations of existing process units Perform calculations, develop PFDs and P&IDs, provide design documentation for downstream engineering disciplines, develop equipment ...

Gantry Tech

Bellwood, IL · On-site

$21.25 - $28.25/hr

Responsible for identifying, correcting, and communicating various up/downstream process issues that reduce process output or impact quality. * Manage the repair of all conveyor components and store ...

Gantry Tech

Bellwood, IL · On-site

$21.25 - $28.25/hr

Responsible for identifying, correcting, and communicating various up/downstream process issues that reduce process output or impact quality. * Manage the repair of all conveyor components and store ...

Staff Process Engineer

Lisle, IL · On-site

$110K - $150K/yr

Lead field and technical evaluations of existing process units Direct and perform calculations, develop PFDs and P&IDs, provide design documentation for downstream engineering disciplines, develop ...

Global Process Owner

Chicago, IL · On-site

$156K - $170K/yr

Collaborate with other functions, upstream and downstream, to align and leverage cross-process opportunities with a focus on enhancing effectiveness and efficiency. Act as a key stakeholder to foster ...

Staff Process Engineer

Lisle, IL · On-site

$110K - $150K/yr

Lead field and technical evaluations of existing process units Direct and perform calculations, develop PFDs and P&IDs, provide design documentation for downstream engineering disciplines, develop ...

Staff Process Engineer

Lisle, IL · On-site

$110K - $150K/yr

... downstream engineering disciplines, develop equipment specifications, compile scope of work ... Knowledge of process simulation software (eg Aspen Plus, HYSYS) preferred • Management:

Downstream Technician

Lacon, IL · On-site

$18.50 - $19.50/hr

We value diverse perspectives, recognizing that they drive better ideas, processes, and performance. Our workplace is built on respect, inclusivity, and shared responsibility, ensuring every team ...

Downstream Technician

Lacon, IL · On-site

$18.50 - $19.50/hr

We value diverse perspectives, recognizing that they drive better ideas, processes, and performance. Our workplace is built on respect, inclusivity, and shared responsibility, ensuring every team ...

Lead Process Engineer

Lisle, IL · On-site

$140K - $185K/yr

... downstream engineering disciplines, develop equipment specifications, compile scope of work ... Advance technical knowledge of refinery and chemical process unit operations and licensed ...

Laboratory Technician

White Hall, IL · On-site

$19.92 - $28.64/hr

Perform minor maintenance on fermentation and downstream processing equipment. * Inform Team Leader of shop floor issues, concerns, and possible solutions. * Demonstrate good housekeeping practices.

Lead Process Engineer

Lisle, IL · On-site

$140K - $185K/yr

... downstream engineering disciplines, develop equipment specifications, compile scope of work ... Advance technical knowledge of refinery and chemical process unit operations and licensed ...

Lead Process Engineer

Lisle, IL · On-site

$140K - $185K/yr

... downstream engineering disciplines, develop equipment specifications, compile scope of work ... process unit operations and licensed technologies • Advanced knowledge of applicable codes and ...

Showing results 41-60

Downstream Process information

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What cities in Illinois are hiring for Downstream Process jobs?

Cities in Illinois with the most Downstream Process job openings:

Infographic showing various Downstream Process job openings in Illinois as of August 2026, with employment types broken down into 1% As Needed, 83% Full Time, 13% Part Time, 2% Contract, and 1% Nights. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution.

Staff Process Engineer

Brindley Engineering

Lisle, IL

$110K - $150K/yr

Full-time

Re-posted 29 days ago


Job description

Job Description:
Detail-oriented, reliable, creative team player to lead/assist in process design for new and existing facilities. Analyze, calculate, and design new or revamped process equipment in refinery, chemical, and other industrial applications.

Job Duties/Responsibilities:
•    Lead field and technical evaluations of existing process units
•    Direct and perform calculations, develop PFDs and P&IDs, provide design documentation for downstream engineering disciplines, develop equipment specifications, compile scope of work packages for construction
•    Lead Client and Contractor interface, attend meetings, and provide written reports
•    Provide technical support for field execution, including outage/turnaround projects
•    Assist in constructability planning, proposal, and estimate development

Minimum Qualifications:
•    Education: Bachelor of Science in Chemical Engineering
•    Experience: Min Yr = 08+
•    Licensure: P.E. Preferred
•    Technical Skills: Knowledge of P&ID development, heat and material balances, hydraulic and equipment sizing calculations, relief device sizing, API standards, and ASME codes required. Knowledge of process simulation software (eg Aspen Plus, HYSYS) preferred
•    Management: Experience mentoring and leading small teams required
•    Other Skills: Strong organizational, written, and verbal communication skills

Professional Development Opportunities:
•    Advanced technical knowledge of refinery and chemical process unit operations and licensed technologies
•    Advance knowledge of applicable codes and standards, involvement in AIChE or similar local/national chapters and code committees (API, ASME etc) 
•    Growth in leading technical teams as a subject matter expert or lead engineer
•    Advance skills in a multi-disciplinary technical and managerial environment

Individual field assignments typically have their own unique requirements.  Prior to deployment on any field assignment, you must be able to meet all client-specific site requirements.  Should you be unable or unwilling to meet assignment-specific requirements, your continued employment would then be subject to the availability of other assignments whose requirements can be met.  These unique requirements may include:

•    You must possess physical mobility (on the ground and at heights).
•    You may be required to pick up, lift, carry, and move up to 50 lbs.
•    You may be required to work at heights, climb ladders and stairways, and may occasionally work off platforms/scaffolding/ladders using the appropriate and required fall protection.  
•    You must be able to work in all weather conditions (including heat, rain, cold, and wind) while wearing the appropriate PPE. This may include, but not be limited to, a hard hat, safety glasses/goggles, earplugs, masks/respirators, hi-vis safety vests, leather gloves, and leather, steel-toed work boots.  
•    You may be required to position yourself to work in confined spaces
•    You may be required to adhere to a client’s random drug testing program prior to entering their site.
•    You may be required to meet a client’s facial hair safety policy prior to entering their site.

Pay Range: $110,000 - $150,000 annually
The above pay range represents a general guideline; however, Brindley considers several factors when determining base salary that are unique to each candidate, including but not limited to the candidate's depth of experience, skill set, certifications, specific work location, and current market conditions. Employees may be eligible for a discretionary bonus and/or other applicable incentive compensation plans in addition to base pay to reward individual contributions and allow employees to share in company results.

In addition, BE provides a comprehensive benefits package for eligible employees, including health, dental, and vision insurance, life and disability insurance, 401(k) savings plan with employer matching, company-paid holidays, paid parental leave, compensatory time off, and paid time off (PTO). Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment.
Brindley Engineering is an Equal Opportunity Employer and is committed to hiring and retaining a diverse workforce. Employment decisions are made without regard to race, color, religion, creed, sex, sexual orientation, gender identity, marital status, national origin, age, veteran status, disability, or any other protected characteristic as outlined by federal, state, or local laws.

BE participates in E-Verify. For additional information regarding E-Verify, please go to www.e-verify.gov.