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Downstream Process Jobs in Missouri (NOW HIRING)

Resolve cross-functional process and integration issues, oversee system enhancements, and evaluate the downstream financial and operational impacts of changes to ensure business continuity and system ...

Resolve cross-functional process and integration issues, oversee system enhancements, and evaluate the downstream financial and operational impacts of changes to ensure business continuity and system ...

Welder | 2nd Shift

Kansas City, MO · On-site

$23 - $24/hr

Transfer finished pipe to carts and staging areas for downstream processing or shipment. * Operate pneumatic banding equipment to prepare finished pipe bundles for shipping when required. * Read work ...

Transfer finished pipe to carts and staging areas for downstream processing or shipment. * Operate pneumatic banding equipment to prepare finished pipe bundles for shipping when required. * Read work ...

Contract Management Specialist

Chesterfield, MO · On-site

$95K - $115K/yr

Ensure accurate downstream processing of contracts, orders, billing, and invoicing. * Maintain compliance with company contracting, pricing, and approval policies. Customer & Cross-Functional Support

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Downstream Process information

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Missouri? For Downstream Process jobs in Missouri, the most frequently searched job titles are:
Infographic showing various Downstream Process job openings in Missouri as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution.

Sr. Downstream Processing Technician

Actalent

Saint Louis, MO

$30/hr

Contractor

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 2 days ago


Job description

Job Title: Downstream Processing Technician III

Job Description

Are you ready to take your career in manufacturing to the next level? We are currently seeking a highly skilled and motivated Downstream Processing Technician III to join our world-class team in St. Louis. As a leading company in the scientific research industry, we are dedicated to enabling our customers to make the world healthier, cleaner, and safer. In this role, you will have the opportunity to work with a team of exceptional professionals and play a vital role in the flawless execution of manufacturing batch records, work instructions, and SOPs. Your keen attention to detail and proactive approach will ensure that all tasks are completed right the first time. Additionally, you will assist in maintaining the suite, supplies, equipment, logbooks, and data to strict cGMP standards, contributing to the success of our manufacturing operations.

Responsibilities

  • Execute manufacturing batch records, work instructions, and SOPs with a focus on proactive ‘right the first time’ executions.
  • Assist with batch record reconciliation.
  • Maintain suite, supplies, equipment, logbooks, and data according to site SOPs and policies.
  • Document all activities to meet cGMP requirements and complete document reviews and revisions.
  • Participate in daily record reviews, tasks, and databases, actively providing feedback.
  • Participate and lead in shift exchanges, 1-1’s, and meetings as needed to facilitate area needs based on changes.
  • Support quality investigations by answering questions, providing feedback, and suggesting improvements.
  • Practice and promote safe work habits, adhering to safety procedures and guidelines.
  • Critically evaluate processes with foresight and forward-thinking.
  • Ensure tasks are performed with prioritization, interpreting production schedules to complete tasks accordingly.

Essential Skills

  • Proficiency in cleanroom and aseptic techniques.
  • Bachelor's Degree in a STEM-related field.
  • Minimum of 2 years of work experience in manufacturing, operation, production, lab setting, or related field.

Additional Skills & Qualifications

  • Preferred experience in a cGMP environment and a 4-year STEM degree.
  • Knowledge of cGMP practices, aseptic techniques, or chemical concepts.
  • Subject Matter Expert on downstream processing steps.

Work Environment

Work in a clean room/aseptic suite environment, requiring gowning in a full suit including bodysuit, gloves, hair & beard nets, face covers, and safety glasses. The role requires the ability to meet cleanroom gowning requirements, lift a minimum of 25 lbs independently, and stand for 80% of the shift.

Job Type & Location

This is a Contract to Hire position based out of Saint Louis, MO.

Pay and Benefits

The pay range for this position is $30.00 - $30.00/hr.

Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: • Medical, dental & vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life & AD&D for the employee and dependents) • Short and long-term disability • Health Spending Account (HSA) • Transportation benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave)

Workplace Type

This is a fully onsite position in Saint Louis,MO.

Application Deadline

This position is anticipated to close on Aug 17, 2026.

About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 20,000 consultants and 5,000 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. We are proud to be an Engineering News-Record (ENR) Top 500 Design Firm for our engineering design services and a ClearlyRated Best of Staffing® winner for both client and talent service.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options.

San Francisco Fair Chance Ordinance: Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.


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About Actalent

Sourced by ZipRecruiter

Actalent connects passion with purpose. Our scalable talent solutions and services capabilities drive value and results and provide the expertise to help our customers achieve more. Every day, our experts around the globe are making an impact. We're supporting critical initiatives in engineering and sciences that advance how companies serve the world. Actalent promotes consultant care and engagement through experiences that enable continuous development. Our people are the difference. Actalent is an operating company of Allegis Group, the global leader in talent solutions.

Company size

5,001 - 10,000 Employees

Headquarters location

Hanover, MD, US

Year founded

1983

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