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Downstream Process Jobs in Indiana (NOW HIRING)

Our leading CDMO client is eager to hire an Aseptic Downstream Process Development SME for their Indianapolis site. This is a full-time role directly with the client - an outstanding opportunity to ...

Collaborate cross-functionally to refine and optimize enzyme fermentation and downstream processing (DSP) workflows to improve yield and scalability. * Hands-on operation of core bioprocessing ...

Bioprocess Engineer

South Bend, IN · On-site

$75K - $95K/yr

Collaborate cross-functionally to refine and optimize enzyme fermentation and downstream processing (DSP) workflows to improve yield and scalability. * Hands-on operation of core bioprocessing ...

Automation Technician

La Porte, IN · On-site

$38.90K/yr

Detail oriented, with record keeping practices that easily allow for determining process changes to downstream results. * Participate in cross-functional team for the purpose of preventing or ...

Automation Technician

La Porte, IN

$38.90K/yr

Detail oriented, with record keeping practices that easily allow for determining process changes to downstream results. * Participate in cross-functional team for the purpose of preventing or ...

Automation Technician

La Porte, IN

$38.90K/yr

Detail oriented, with record keeping practices that easily allow for determining process changes to downstream results. * Participate in cross-functional team for the purpose of preventing or ...

Automation Technician

La Porte, IN

$38.90K/yr

Detail oriented, with record keeping practices that easily allow for determining process changes to downstream results. * Participate in cross-functional team for the purpose of preventing or ...

The Process Technician is responsible for the setup, monitoring, and optimization of plastic ... Set up and operate secondary or downstream equipment as needed. * Perform routine preventive ...

The Process Technician is responsible for the setup, monitoring, and optimization of plastic ... Set up and operate secondary or downstream equipment as needed. * Perform routine preventive ...

The Process Technician is responsible for the setup, monitoring, and optimization of plastic ... Set up and operate secondary or downstream equipment as needed. * Perform routine preventive ...

Postdoctoral Fellow

Bloomington, IN · On-site

$45.30K - $61.50K/yr

The primary goal of the lab is to characterize the role of nuclear pore complex machinery in mediating HIV-1 nuclear entry and subsequent downstream process that leads to productive viral gene ...

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Downstream Process information

See Indiana salary details

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How much do downstream process jobs pay per hour?

As of May 30, 2026, the average hourly pay for downstream process in Indiana is $23.48, according to ZipRecruiter salary data. Most workers in this role earn between $18.75 and $26.78 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What cities in Indiana are hiring for Downstream Process jobs? Cities in Indiana with the most Downstream Process job openings:
Infographic showing various Downstream Process job openings in Indiana as of May 2026, with employment types broken down into 2% Internship, 90% Full Time, 2% Temporary, 4% Contract, and 2% Nights. Highlights an 97% In-person, and 3% Remote job distribution, with an average salary of $48,833 per year, or $23.5 per hour.

Aseptic Process Development - CDMO

MEDVACON

Indianapolis, IN

Full-time

Posted 10 days ago


Job description

Company Description

MEDVACON Life Sciences works with many leading pharmaceutical companies to hire consulting, contract and full-time employees to join client organizations.

Our focus is cGMP Quality and Compliance, Validation and Regulatory for pharmaceutical and biotechnology companies.

Our leading CDMO client is eager to hire an Aseptic Downstream Process Development SME for their Indianapolis site.  This is a full-time role directly with the client - an outstanding opportunity to join an innovative company developing brilliant biotechnology.

A successful background will be strong in Lab, Process and Analytical development including working knowledge of cGMPs related to the production of viral therapeutics and the ability to interface successfully with multi-disciplined teams.


Job Description

Direct the development and establishment of processes in GMP. 

Accountable for developing a scalable platform for viral vector production processes that minimizes the risk during Process Development to GMP scale-up. 

Provide technical expertise and leadership in science & technology and requires close collaboration with internal stakeholders.

If you're interested so far - apply!  A member of our talent team will contact you and share comprehensive job details. 

Qualifications

Bachelors Degree

5+ years exp in a cGMP pharma/biotech setting

Solid foundation in the fundamentals of biochemical engineering, virology and cell biology

Pharmaceutical industry experience in technical support of cGMP manufacturing and/or process development, including experience with Contract Development and Manufacturing Organizations

Experience with cell culture technologies, molecular biology, and aseptic processing

Additional Information

Please attach a WORD resume to your submission

All of your information will be kept confidential according to EEO guidelines.

ON-SITE only

This is a FT role and will include a full benefits package

40-hour week

NO AGENCIES please