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Downstream Process Jobs in Pennsylvania (NOW HIRING)

PA · On-site

$95 - $143/hr

Overview The Downstream Process Support Engineer will work with the Central Engineering and Plant Operations teams across Graham Packaging North America to drive standardization, optimization, and ...

Scientist - Downstream Vaccines and Advanced Biotechnologies Process R&D - - Our Company in Rahway, N.J., U.S.A. known as Our Company in the United States and Canada, is a global health care leader ...

Internship IBEX MSAT DSP 80-100% (m/w/d)

Indiana, PA · On-site

$13.75 - $17.75/hr

Focus is on Downstream process (DSP) * Collaboration with manufacturing * Supporting process validationSupporting deviations and change management * Preparation of the required GMP compliant ...

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Downstream Process information

See Pennsylvania salary details

$13

$24

$35

How much do downstream process jobs pay per hour?

As of Aug 22, 2026, the average hourly pay for downstream process in Pennsylvania is $24.73, according to ZipRecruiter salary data. Most workers in this role earn between $19.76 and $28.17 per hour, depending on experience, location, and employer.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What job categories do people searching Downstream Process jobs in Pennsylvania look for?

The top searched job categories for Downstream Process jobs in Pennsylvania are:

What cities in Pennsylvania are hiring for Downstream Process jobs?

Cities in Pennsylvania with the most Downstream Process job openings:

Infographic showing various Downstream Process job openings in Pennsylvania as of August 2026, with employment types broken down into 1% As Needed, 75% Full Time, 21% Part Time, 2% Contract, and 1% Nights. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $51,442 per year, or $24.7 per hour.

Downstream Process Support Engineer

Graham Packaging Company

PA • On-site

$95 - $143/hr

Other

Medical, Dental, Vision, Life, Retirement, PTO

Posted 4 days ago


Graham Packaging rating

7.0

Company rating: 7.0 out of 10

Based on 53 frontline employees who took The Breakroom Quiz

71st of 121 rated packaging manufacturers


Job description

Company Statement

Graham Packaging is a people, planet and values-based company and a leader in sustainable packaging manufacturing. From the kitchen to the laundry room, Graham Packaging is part of your everyday life. For employees at Graham, our Blue Culture is part of their everyday lives, too. In other words, Blue is how we do things here. At Graham, we are united by a clear vision. We know our part and help those around us know theirs, encouraging one another to continuously improve. We create a safe, challenging environment to innovate by supporting creative ideas and new ways of thinking. We take the initiative to cultivate our individual growth and help others do the same, while keeping ourselves and one another accountable. And we actively promote cooperation, collaboration, integrity and respect across regions and teams to foster an engaged, diverse and connected workforce. We value our employees, and a Blue Culture allows for the most rewarding employee experience as part of the Graham family. Blue is how we feel about what we do—together—to create a better tomorrow. Working at Graham means you lead constructively with clear goals, use diverse thinking to drive excellence, accountability, innovation, as well as demonstrating collaboration, embracing learning, and taking action for continuous improvement and growth.

Overview

The Downstream Process Support Engineer will work with the Central Engineering and Plant Operations teams across Graham Packaging North America to drive standardization, optimization, and improvement in Post-Molding Applications. These include trimmers, labelers, inspection systems, palletizers, case packers, case formers, partition inserters, robotics, and other automatic packaging equipment.

This role is responsible for improving the reliability, maintainability, and performance of downstream and supporting equipment. The engineer develops and deploys standardized engineering solutions, maintenance strategies, automation initiatives, and best practices that improve equipment uptime, reduce downtime, and optimize overall manufacturing performance.

In addition to traditional engineering support, this position is responsible for leveraging Automation Intelligence, digital technologies, AI-enabled analytics, predictive maintenance tools, and knowledge management systems to improve equipment performance, standardize engineering practices, and accelerate problem resolution across multiple manufacturing sites.

The Downstream Process Support Engineer will develop, implement, audit, and continuously improve proactive, preventive, predictive, and reliability-centered maintenance programs while leading root cause investigations, equipment optimization, technical training, and enterprise-wide knowledge sharing.

Responsibilities

Engineering & Technical Support

  • Provide hands-on engineering support and deployment of post-molding process solutions.
  • Assess and recommend technical solutions to improve machine efficiency, reliability, and uptime.
  • Participate in installations, factory and plant acceptance tests, and system commissioning.
  • Build or re-purpose automatic trimming and packaging systems using new or existing hardware/software.
  • Provide reliability input for capital project activities.
  • Review equipment specifications and vendor quotes to ensure performance requirements are met.
  • Create technical work instructions, machine audits, and documentation for operation and maintenance.
  • Provide 24/7 remote technical support for plant operations as needed.
  • 75% travel

Standardization & Continuous Improvement

  • Lead and support standardization efforts across vertical units.
  • Use analytical tools, statistical methods, and problem-solving frameworks (A3, 8D) to address issues.
  • Use data-driven methods to track progress and sustain improvements.
  • Develop and maintain accurate records, reports, and action plans for short- and long-term issue resolution.
  • Develop and maintain standardized engineering documentation, equipment standards, Standard Operating Conditions (SOCs), maintenance procedures, troubleshooting guides, and best practice documentation.
  • Document root cause investigations, engineering modifications, and equipment improvements for enterprise-wide use.
  • Standardize maintenance practices across the North American manufacturing network.
  • Create training materials and technical documentation that improve organizational knowledge retention and reduce dependency on individual expertise.
  • Ensure engineering documentation remains current following equipment modifications, upgrades, and continuous improvement initiatives.

Training & Collaboration

  • Conduct classroom and on-the-floor training for trimming and packaging systems.
  • Train plant personnel on operational procedures such as changeovers and system adjustments.
  • Collaborate with plant operations and engineering teams to ensure optimal performance and alignment.
  • Develop and maintain positive working relationships across teams.
  • Submit weekly reports on engineering hours, travel, and expenses.

Automation Systems Knowledge

  • Maintain working knowledge of major post-molding packaging platforms, including:
    • Palletization systems: Zecchetti, OMS, Schneider, OMS
    • Trimming systems: Autotec, Lectro, Lyle, Maer, Mueller, Uniloy
    • Quality Inspection systems: Tornado, ALPs, Intravis, KMV
Qualifications

Education

  • BS or AAS in Electrical or Mechanical Engineering preferred.

Experience

  • Minimum 8-10 years of experience improving processes with automatic post-molding systems (trimmers, labelers, inspection, palletizing, case packing, etc.).
  • At least 10 years of combined experience as a service technician, controls engineer, project manager, or plant engineer.
  • Prior experience with PLCs (Siemens, Allen-Bradley, Beckhoff, B&R) and servo control systems.
  • Experience in full lifecycle system implementation and integration.
  • Working knowledge of analytical and statistical quality tools.
  • Prior experience with PLCs a plus- Siemens, Allen Bradley, Beckhoff, B&R and Servo Control Systems
  • Prior experience with welding- Mig, Tig, and Stick.
  • Prior shop equipment experience- Mill, Layth, & basic power tools.
  • Installing high and low voltage systems.
  • Must be able to read mechanical and electrical prints

Technical Competencies

  • Strong troubleshooting and analytical thinking skills.
  • Proficiency in Microsoft Office, Power BI, CAD, and automation software.
  • Ability to write clear technical documents, reports, specifications, and change bulletins.
  • Functional understanding of industrial safety practices (Lockout/Tagout, Energy Control, Electrical Safety).
  • Prior experience utilizing a CMMS system, SAP a plus.
  • Prior experience utilizing DMAIC principles a plus.

Soft Skills

  • Self-motivated, goal-oriented, and an effective team player.
  • Excellent communication and interpersonal skills.
  • Strong multitasking and organizational abilities with diligent follow-up.
  • Ability to motivate and engage both hourly and salaried personnel.

The standard compensation for this role is $95,400 - 143,100. Salary offers will be determined based on final candidate qualifications, experience, skillset, and other relevant factors.

Compensation Statement

The expected salary range for the position described in this posting is made in accordance with the legal mandates of certain jurisdictions within the United States. The final agreed-upon compensation is based on individual qualifications and experience.

Benefits Statement

Benefits include medical, dental, vision and basic life insurance. Employees are able to enroll in the company’s 401K Employee Saving Plan and may participate in its Employee Wellness Program. Employees will also receive paid time off in accordance with company policy and state law requirements.

EEO Disclaimer

Graham Packaging is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, sex (including pregnancy), sexual orientation, religion, creed, age, national origin, physical or mental disability, gender identity and/or expression, marital status, veteran status or other characteristics protected by law.

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About Graham Packaging

Sourced by ZipRecruiter

Graham Packaging is a people, planet and values-based company and a leader in sustainable packaging manufacturing. From the kitchen to the laundry room, Graham Packaging is part of your everyday life. For employees at Graham, our Blue Culture is part of their everyday lives, too. In other words, Blue is how we do things here.

Industry

Plastics and rubber products manufacturing

Company size

10,000+ Employees

Headquarters location

York, PA, US

Year founded

1970