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Director Enterprise Risk Management Jobs (NOW HIRING)

APS

Director Enterprise Risk

Phoenix, AZ · On-site

Serves as a trusted advisor to management on risk-related matters and promotes a culture of risk ... directing enterprise-wide initiatives. * Demonstrated knowledge of enterprise risk management ...

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Director Enterprise Risk Management information

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$54K

$143.2K

$260K

How much do director enterprise risk management jobs pay per year?

As of Aug 29, 2026, the average yearly pay for director enterprise risk management in the United States is $143,185.00, according to ZipRecruiter salary data. Most workers in this role earn between $105,500.00 and $167,500.00 per year, depending on experience, location, and employer.

What does a director enterprise risk management do?

A Director of Enterprise Risk Management (ERM) is responsible for identifying, assessing, and mitigating risks that could impact an organization’s ability to achieve its objectives. They develop risk management strategies, policies, and frameworks, and work closely with senior leadership to integrate these practices across departments. The role involves overseeing risk assessments, monitoring compliance with regulations, and ensuring the organization is prepared for potential threats. By proactively managing risks, the director helps safeguard the organization's assets, reputation, and long-term success.

How does a director enterprise risk management typically collaborate with other departments to identify and mitigate organizational risks?

A Director of Enterprise Risk Management (ERM) works closely with leaders across departments such as compliance, finance, IT, and operations to proactively identify, assess, and address organizational risks. This often involves facilitating risk workshops, leading cross-functional risk assessments, and ensuring risk mitigation strategies are embedded in business processes. Regular communication and reporting to executive leadership and the board are also key responsibilities, enabling a holistic view of the risk landscape. Effective collaboration helps ensure that risk management is integrated throughout the organization, supporting both strategic objectives and regulatory compliance.

What are the key skills and qualifications needed to thrive as a director enterprise risk management, and why are they important?

To thrive as a Director of Enterprise Risk Management, you need expertise in risk assessment, regulatory compliance, and strategic planning, typically supported by a bachelor's or master's degree in business, finance, or a related field. Familiarity with risk management frameworks (such as COSO or ISO 31000), GRC (governance, risk, and compliance) systems, and relevant certifications like CRM or FRM is highly valued. Exceptional leadership, analytical thinking, and communication skills help you collaborate across departments and influence organizational culture. These abilities are crucial for identifying potential threats, ensuring regulatory compliance, and safeguarding the organization's long-term success.

What is the difference between Director Enterprise Risk Management vs Risk Manager?

AspectDirector Enterprise Risk ManagementRisk Manager
CredentialsTypically requires advanced degrees (MBA, Risk Management certifications)Often requires similar certifications but may have less emphasis on advanced degrees
Work EnvironmentStrategic, leadership-focused, often in senior management teamsOperational, focused on risk assessment and mitigation activities
Employer & Industry UsageUsed in large corporations across various industriesCommon in organizations of all sizes, especially in finance, insurance, and manufacturing
Search & Comparison IntentUnderstanding senior risk leadership rolesOperational risk management responsibilities

The main difference between a Director Enterprise Risk Management and a Risk Manager lies in their scope and seniority. The Director typically oversees enterprise-wide risk strategies and leads teams, while the Risk Manager focuses on specific risk areas and implementation. Both roles require relevant certifications and experience, but the Director position involves more strategic decision-making and leadership responsibilities.

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Director Enterprise Risk Management jobs near you
Infographic showing various Director Enterprise Risk Management job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 84% Full Time, 13% Part Time, and 2% Contract. Highlights an 83% Physical, 2% Hybrid, and 15% Remote job distribution, with an average salary of $143,185 per year, or $68.8 per hour.

Director, Enterprise Risk Management

Cabaletta Bio Inc.

Philadelphia, PA • On-site

Full-time

PTO

Posted 16 days ago

Job description

Position Director, Enterprise Risk Management 

Location: Philadelphia, (hybrid)

Reports to: Chief Compliance Officer

Cabaletta Bio (Nasdaq: CABA) is a late-stage clinical biotechnology company focused on developing and launching curative targeted cell therapies designed specifically for patients with autoimmune diseases. The CABA platform encompasses two complementary strategies which aim to advance the discovery and development of engineered T cell therapies with the potential to become deep and durable, perhaps curative, treatments for a broad range of autoimmune diseases. The lead CARTA (Chimeric Antigen Receptor T cells for Autoimmunity) strategy is prioritizing the development of rese-cel, a 4-1BB-containing fully human CD19-CAR T cell investigational therapy. Rese-cel is currently being evaluated in the RESET (REstoring SElf-Tolerance) clinical development program spanning multiple therapeutic areas, including rheumatology, neurology and dermatology. Cabaletta Bio's headquarters and labs are located in Philadelphia, PA. For more information, please visit www.cabalettabio.com and connect with us on LinkedIn.

Uniquely Differentiated. Rapid. Elegant.

At Cabaletta, we are driven by the shared mission of developing cures, where a patients' own cells are used to fight disease. We are building a culture grounded in the knowledge that successful cures can be achieved for patients if every member of the Cabaletta is focused on the success of the team. To nurture this, we make an active commitment to the well-being and continuous growth of each employee who joins the team. In this way, we are not only working to improve the lives of patients, but of everyone involved. #CabalettaCrew. 

We're proud to be a Great Place to Work-Certified company! #GPTWcertified Check out what our employees say makes working here so great:  Working at Cabaletta Bio Inc | Great Place to Work

About the Position:

Cabaletta Bio is seeking a Director, Enterprise Risk Management to establish and lead the company's enterprise risk management (ERM) program as we advance toward BLA submission and commercial launch. Reporting to the Chief Compliance Officer, this role will build a structured, company-wide approach to identifying, assessing, mitigating, and monitoring risk across clinical, regulatory, quality, and commercial operations. A core focus of the role is quality risk management across the product lifecycle, including risk-based oversight of the company's external manufacturing network of three CDMOs, ensuring the risk management framework scales with the organization as it prepares for its first product launch.

This is a highly visible, cross-functional role suited to someone who can stand up a program from the ground floor, engage executive leadership and functional heads, and translate risk insights into practical, prioritized action.

Responsibilities:

Enterprise Risk Management
  • Design, implement, and lead the enterprise risk management framework, including governance structure, risk taxonomy, risk appetite statements, and escalation pathways
  • Facilitate periodic enterprise risk assessments with executive leadership and functional owners; maintain the corporate risk register and heat maps
  • Partner with functional leaders (Clinical, Regulatory, Quality, CMC, Commercial, IT, Finance, Legal) to identify emerging risks, define mitigation plans, and track remediation to closure
  • Develop and deliver risk reporting to the executive team and, as appropriate, the Board or Board committees
  • Integrate risk management with related programs, including quality risk management (ICH Q9 principles), business continuity, third-party/vendor risk, and inspection readiness
  • Monitor the external environment (regulatory enforcement trends, industry events, evolving guidance) and translate implications into the risk program
Quality Risk Management & External Manufacturing Oversight
  • Lead the application of quality risk management principles (ICH Q9(R1)) across the product lifecycle, including risk assessments supporting manufacturing, supply chain, and quality operations
  • Establish and maintain a risk-based framework for oversight of the company's external manufacturing network, including three CDMOs, spanning vendor risk assessments, ongoing risk monitoring, and periodic risk reviews
  • Partner with CMC, Quality, and Supply Chain to assess and manage risks associated with CDMO performance, including deviations, change control, capacity, technology transfer, comparability, and business continuity
  • Integrate CDMO and third-party risk into the corporate risk register with clear ownership, mitigation plans, and escalation criteria; ensure risk considerations are reflected in quality agreements and governance forums (e.g., joint steering committees, quality business reviews)
  • Support risk-based prioritization of vendor audits and person-in-plant or oversight activities in partnership with GxP Quality Audit
  • Ensure risk documentation supporting external manufacturing is inspection-ready and aligned with BLA submission expectations
Program Leadership
  • Serve as a trusted advisor to the CCO and functional leadership on risk matters
  • Contribute to inspection readiness and BLA-related activities where risk management documentation and governance are in scope
  • Build scalable tools, templates, and processes appropriate for a clinical-stage company transitioning to commercial operations
  • Potential to build and manage a small team as the function grows

Required Qualifications:

 

  • Bachelor's degree in life sciences, business, finance, or related field
  • 10+ years of progressive experience in the biopharmaceutical industry, with significant experience in enterprise risk management and quality risk management
  • Demonstrated experience designing or leading an ERM program (framework development, risk assessments, risk registers, executive reporting)
  • Hands-on experience applying quality risk management (ICH Q9) in a GxP environment, including risk assessments supporting external/contract manufacturing
  • Experience managing or overseeing risk across multiple CDMOs or contract manufacturing partners, including vendor risk assessment and governance
  • Experience supporting or operating within a pre-launch or newly commercial organization
  • Strong facilitation, analytical, and communication skills; able to engage credibly with executives and functional experts alike
  • Comfort with ambiguity and a hands-on, roll-up-your-sleeves orientation appropriate for a clinical-stage company

Preferred Qualifications:

  • Advanced degree (MBA, MS) or relevant certification (e.g., CRMP, ARM, CQA)
  • Experience in cell and gene therapy, rare disease, or other specialty/complex products
  • Experience with cell therapy or viral vector external manufacturing networks and associated supply chain risk
  • Experience presenting to boards or board committees

 

Our name - Cabaletta - is derived from the operatic term that represents a rapid, repetitive, and technically challenging section of an operatic aria, designed to showcase the skills of the lead singer. Analogously, Cabaletta Bio strives to achieve rapid and repetitive product development, building on our indication prioritization and biologic platform that targets the driver of specific autoimmune diseases without the need for long-term immunosuppression.

For more information, please visit  https://www.cabalettabio.com/join-our-crew

Our most important asset is our people, and we offer competitive benefits, PTO, and stock option plans.

Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.

Cabaletta Bio, Inc. does not accept unsolicited resumes from recruiters, employment agencies, or staffing firms. To conduct business with Cabaletta, a Master Services Agreement (MSA) must be executed and confirmed prior to submitting any information relating to a potential candidate. Without a signed MSA, Cabaletta shall not be responsible to any individual or entity for any payment relating to any form of fee or compensation.

And, if a resume or candidate is submitted by a recruiter, an employment agency, or a staffing firm without a fully executed MSA, Cabaletta has the unrestricted right to pursue and hire any of those candidate(s) without any legal or financial responsibility to the recruiter, agency, and/or firm.

 

#LI-HYBRID

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