Research Scientist I

Our Opportunity:

C4 Therapeutics is seeking an enthusiastic, scientifically-motivated Research Scientist to join our Biology team. The candidate will play a significant role in the design and execution of in vitro and in vivo studies to characterize and differentiate the biological consequences of our small molecule therapeutics to advance drug discovery programs. The ideal candidate will possess a background in cancer biology and experience in a drug discovery setting. In addition, the successful candidate will have a strong commitment to team success, an ability to work effectively as part of a team, and the ability to work on multiple projects simultaneously. This position seeks individuals who are comfortable in a fast-paced environment and are interested in and committed to laboratory-based research and innovation. This position will provide many opportunities for high impact work and the chance to influence the direction of a project in a data-driven manner. C4 Therapeutics is committed to investing in all our employees by providing strong and compassionate leadership, defined career growth opportunities, exposure to state-of-the-art techniques, generous employee benefits packages, and a positive and supportive workplace environment filled with highly talented and collaborative colleagues.

Key Responsibilities:

• Design and execute cell-based studies to support identification, validation, and differentiation of small molecule protein degraders, implementing a wide variety of laboratory techniques including mammalian cell culture, Western blotting, CRISPR, RNAi, phenotypic assays, flow cytometry, etc.
• Act as the Biology Lead in efforts to advance drug discovery projects in a multidisciplinary, collaborative project team setting: perform cell-based studies and design and manage the execution of in vivo studies at CROs to achieve project goals, interpret and communicate results, and recommend next steps to the project teams.
• Build a deep understanding of our targets as they progress through the phases of drug discovery towards the clinic.
• Manage CROs for outsourced work, including in vitro and in vivo studies (no vivarium on site).
• Understand and integrate the current literature surrounding TPD and specific targets of interest
• Maintain written records of laboratory experiments, data, conclusions, and communicate results in a clear/concise manner.
• Contribute to collaborative problem solving with cross functional teamwork.

Your Background:

• Ph.D. in Biology or other relevant discipline, M.S. with 2+ years of experience working in an industry setting, or BS with 5+ years of experience working in an industry setting.
• Strong record of success in critical thinking and scientific creativity demonstrated by publications and/or drug discovery experience.
• Demonstrated hands-on experience in independent experimental design, execution, data analysis and troubleshooting.
• Background in cancer biology is preferred.
• Demonstrated proficiency with mammalian cell culture techniques is preferred.
• Self-motivated, willingness to learn, strong work ethic, attention to detail, organizational skills, and excellent communication skills.
• Proficiency in utilizing software such as Microsoft Office, GraphPad Prism, etc.
• Works well in a collaborative team-oriented environment and is capable of multi-tasking in an exciting, fast-paced environment.

C4 Therapeutics is an Equal Opportunity Employer.