SCIENTIST - IN VIVO PHARMACOLOGY - PRECLINICAL

Position: Scientist – In vivo Pharmacology – Preclinical

We are seeking a dedicated and highly skilled Scientist for our Preclinical Team. The successful candidate will be supporting the progression of our therapeutic programs by conducting and optimizing in vivo research activities and successful execution of preclinical studies. This role demands a solid understanding of in vivo research methodologies and the ability to perform in complex operations.

Responsibilities:

• Work with the Associate Director, providing in vivo pharmacology expertise.
• Plan, execute and manage in vivo studies, including protocol development, dosing and tissue collection, study monitoring, bio sample management, tissue processing and relevant data analysis.
• Proficient in administering substances by intravenous (IV) -MUST-, intraperitoneal (IP), subcutaneous (SC), intramuscular (IM) and Intertumoral (IT) injections.
• Execute cell-based assays and experiments of tissues from in vivo studies, perform analyses, and report results.
• Conduct survival surgeries to establish various rodent models using aseptic techniques.
• Develop, characterize and implement new animal models to improve the effectiveness of in vivo pharmacology studies.
• Maintain detailed documentation of all studies in lab notebook to ensure data integrity and traceability
• Optimize and implement best practices for in vivo research methodologies, including animal model selection, dosing strategies, sample collection and data collection techniques
• Ensure compliance with regulatory guidelines and ethical standards in the conduct of in vivo studies
• Evaluate and implement new technologies and platforms to enhance the efficiency and quality of in vivo studies
• Perform and analyze preclinical imaging studies (IVIS)
• Contributes to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion
• Other required duties as may be assigned

Requirements:

• DVM or Ph.D. with expertise in nonclinical operations in a drug discovery and development setting
• Broad and extensive expertise with all aspects of in vivo rodent research (various dosing routes, anesthesia, surgical procedures, necropsy, tissue processing, etc.)
• 3Rs-centered, welfare-oriented approach to animal-based research
• Strong communication skills, essential for effective collaboration with cross-functional teams and CROs used for outsourced studies
• Exceptional organizational and attention to detail skills, with the capacity to work autonomously as well as in a team setting
• Ability to troubleshoot and effectively solve problems in a timely and efficient manner, demonstrating resourcefulness and a high level of analytical thinking
• Hands-on experience with cell biology techniques (RNA/DNA extraction, PCR, Western Blot, ELISA, small molecule/biologics interventional assays)
• Experience working across diverse therapeutic modalities, including small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy is desirable
• Experience analyzing age-related diseases/deficits in animal models; including inflammation, metabolic disorders, neurodegeneration, muscle atrophy, bone loss and/or joint deficits
• Experience with metabolic chambers, behavioral assay and analysis is a desirable.