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Upstream Bio Jobs (NOW HIRING)

Avid Bioservices

Cell Line Development

Tustin, CA · On-site

Partner with Upstream and Downstream Process Development and Analytical teams to deliver integrated ... Strong knowledge of mammalian cell culture, molecular biology techniques and bio process ...

ZymoChem

Lab Assistant

San Leandro, CA · On-site

$28 - $34/hr

We are building bio-based materials that make everyday products better for people and the planet ... Currently, the lab operation team is supporting four departments across upstream, downstream ...

Krystal Biotech

Bioprocess Engineer

Moon Township, PA · On-site

About Krystal Bio: At Krystal Biotech, we bring together the brightest and most eager minds to ... The ideal candidate will have foundational experience in upstream and/or downstream biologics or ...

ZymoChem

Lab Assistant

San Leandro, CA · On-site

We are building bio-based materials that make everyday products better for people and the planet ... Currently, the lab operation team is supporting four departments across upstream, downstream ...

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$29K

$59.8K

$109K

How much do upstream bio jobs pay per year?

As of Jun 5, 2026, the average yearly pay for upstream bio in the United States is $59,773.00, according to ZipRecruiter salary data. Most workers in this role earn between $42,500.00 and $70,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Upstream Bioprocessing Scientist, and why are they important?

To thrive as an Upstream Bioprocessing Scientist, you need a strong background in biology, chemistry, and biochemical engineering, typically supported by a degree in a related field. Experience with bioreactors, cell culture systems, process optimization, and familiarity with GMP regulations and analytical tools are essential. Problem-solving, teamwork, and attention to detail are crucial soft skills for excelling in complex laboratory environments. These competencies ensure efficient development and scaling of biologics production, directly impacting product quality and regulatory compliance.

What is an Upstream Bio scientist?

An Upstream Bio scientist focuses on the early stages of bioprocessing, specifically cultivating and optimizing the growth of cells or microorganisms to produce desired biological products such as proteins or antibodies. Their work includes developing cell lines, optimizing culture conditions, scaling up processes from laboratory to industrial scale, and ensuring high yields and quality. Upstream Bio scientists play a critical role in biotechnology, pharmaceuticals, and biomanufacturing, working closely with downstream processing teams to ensure efficient and successful product development.

What are the typical daily responsibilities of an upstream bioprocessing professional in a biotechnology company?

Upstream bioprocessing professionals typically focus on cultivating and optimizing cell cultures to produce biological products such as proteins or vaccines. Daily tasks often include preparing media, monitoring bioreactor parameters, sampling and analyzing cell growth, and troubleshooting process deviations. Collaboration with downstream processing teams and quality control is frequent to ensure seamless handoff and product quality. Additionally, maintaining detailed records and contributing to process improvement initiatives are key parts of the role.

What is the difference between Upstream Bio vs Downstream Bio?

AspectUpstream BioDownstream Bio
Focus AreaEarly-stage research, target discovery, molecular biologyProduct development, manufacturing, formulation
Required CredentialsBiochemistry, molecular biology, cell biology degreesBiochemistry, pharmaceutical sciences, chemical engineering degrees
Work EnvironmentResearch labs, biotech startups, academic collaborationsManufacturing facilities, quality control labs, biotech companies

Upstream Bio primarily involves early research and target identification, while Downstream Bio focuses on product development and manufacturing processes. Both roles require strong backgrounds in biology or chemistry, but they differ in their specific focus areas and work environments. Understanding these differences helps professionals choose the right career path within the biotech industry.

More about Upstream Bio jobs
What cities are hiring for Upstream Bio jobs? Cities with the most Upstream Bio job openings:
What states have the most Upstream Bio jobs? States with the most job openings for Upstream Bio jobs include:
What job categories do people searching Upstream Bio jobs look for? The top searched job categories for Upstream Bio jobs are:
Upstream Bio jobs near you
Infographic showing various Upstream Bio job openings in the United States as of May 2026, with employment types broken down into 2% As Needed, 79% Full Time, 16% Part Time, 1% Temporary, and 2% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $59,773 per year, or $28.7 per hour.
Cell Line Development

Cell Line Development

Avid Bioservices

Tustin, CA • On-site

Full-time

Posted 16 days ago

Job description

As a Cell Line Development Scientist, you will play a critical role in establishing high-performing mammalian cell lines that enable early-phase biologics programs. This position offers the opportunity to shape foundational capabilities in a fast-paced, collaborative environment focused on innovation and client success.

  • Design and execute strategies for stable cell line development using CHO cell line systems.
  • Perform hands-on CHO cell line development and characterization studies, including transfection, selection, single cell subcloning, growth and productivity screening, cell banking and stability assessment of cell banks.
  • Culture mammalian cells across multiple scales and formats, from 96-well plates up to large shake flasks, experience with ambr 250 and bioreactors is ideal.
  • Implement high-throughput screening and automation tools for clone evaluation.
  • Maintain rigorous documentation and ensure compliance with quality and regulatory standards.
  • Author and review cell line development reports, summaries, and presentations.
  • Present updates at client and cross-functional meetings.
  • Partner with Upstream and Downstream Process Development and Analytical teams to deliver integrated solutions.
  • Contribute to technology evaluations and continuous improvement initiatives for cell line workflows.

Minimum Qualifications:

  • M.S. in Cell Biology, Molecular Biology, Biochemistry, or related field.
  • 2-5 years of industry experience in cell development for biologics.
  • Hands-on experience with CHO cell systems, transfection methods, and clone screening for production of monoclonal antibodies, antibody-like molecules, enzymes, cytokines, bi-specifics and other recombinant molecules.
  • Strong knowledge of mammalian cell culture, molecular biology techniques and bio process engineering concepts.
  • Proficient in aseptic mammalian cell culture techniques.
  • Familiarity with automation platforms and data analysis tools.
  • Excellent problem-solving and communication skills.

Apply