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Upstream Bio Jobs (NOW HIRING)

Kelly Services

Scientist I

Spring House, PA

Salary/Pay Rate/Compensation: $33.60 per hourRegular shift - 5 days per week with mandatory 1 day work weekend (you can choose either Saturday or Sunday) Looking for Cell Culture , Upstream , Bio ...

New

ExxonMobil

Bio Feedstock Trader

Spring, TX · On-site

The success of our Upstream, Product Solutions and Low Carbon Solutions businesses is the result of ... Bio Feedstock Trader to join our growing North American Biofuels team. In this role, you will ...

ExxonMobil

Bio Feedstock Trader

Spring, TX

The success of our Upstream, Product Solutions and Low Carbon Solutions businesses is the result of ... Bio Feedstock Trader to join our growing North American Biofuels team. In this role, you will ...

ExxonMobil

Bio Feedstock Trader

Spring, TX

The success of our Upstream, Product Solutions and Low Carbon Solutions businesses is the result of ... Bio Feedstock Trader to join our growing North American Biofuels team. In this role, you will ...

Exxon Mobil

Bio Feedstock Trader

Spring, TX · On-site

$120 - $180/hr

The success of our Upstream, Product Solutions and Low Carbon Solutions businesses is the result of ... Bio Feedstock Trader to join our growing North American Biofuels team. In this role, you will ...

RWDC Industries

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Bioprocess Technicians

Athens, GA · On-site

$45K/yr

Bioprocess Technician (Upstream) Bioprocess Technician operating seed and production scale ... Our biopolymers are bio-based and made from renewable resources that are biodegradable and ...

Vor Bio

Accountant/Sr Accountant

Boston, MA · On-site

$110K - $135K/yr

... upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing ... Vor Bio is seeking a motivated Accountant or Senior Accountant to join a growing and dynamic team.

RWDC Industries

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Bioprocessing Manufacturing Technician

Winder, GA · On-site

$45K - $46K/yr

... upstream processing equipment. Specific Duties Include: * Serve as a valuable member of the ... Our biopolymers are bio-based and made from renewable resources that are biodegradable and ...

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Upstream Bio information

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How much do upstream bio jobs pay per year?

As of Aug 22, 2026, the average yearly pay for upstream bio in the United States is $59,773.00, according to ZipRecruiter salary data. Most workers in this role earn between $42,500.00 and $70,000.00 per year, depending on experience, location, and employer.

What is an upstream bio scientist?

An Upstream Bio scientist focuses on the early stages of bioprocessing, specifically cultivating and optimizing the growth of cells or microorganisms to produce desired biological products such as proteins or antibodies. Their work includes developing cell lines, optimizing culture conditions, scaling up processes from laboratory to industrial scale, and ensuring high yields and quality. Upstream Bio scientists play a critical role in biotechnology, pharmaceuticals, and biomanufacturing, working closely with downstream processing teams to ensure efficient and successful product development.

What does an upstream bioprocessing scientist do?

Upstream bioprocessing professionals typically focus on cultivating and optimizing cell cultures to produce biological products such as proteins or vaccines. Daily tasks often include preparing media, monitoring bioreactor parameters, sampling and analyzing cell growth, and troubleshooting process deviations. Collaboration with downstream processing teams and quality control is frequent to ensure seamless handoff and product quality. Additionally, maintaining detailed records and contributing to process improvement initiatives are key parts of the role.

What skills and qualifications are needed to thrive as an upstream bioprocessing scientist?

To thrive as an Upstream Bioprocessing Scientist, you need a strong background in biology, chemistry, and biochemical engineering, typically supported by a degree in a related field. Experience with bioreactors, cell culture systems, process optimization, and familiarity with GMP regulations and analytical tools are essential. Problem-solving, teamwork, and attention to detail are crucial soft skills for excelling in complex laboratory environments. These competencies ensure efficient development and scaling of biologics production, directly impacting product quality and regulatory compliance.

What is the difference between Upstream Bio vs Downstream Bio?

AspectUpstream BioDownstream Bio
Focus AreaEarly-stage research, target discovery, molecular biologyProduct development, manufacturing, formulation
Required CredentialsBiochemistry, molecular biology, cell biology degreesBiochemistry, pharmaceutical sciences, chemical engineering degrees
Work EnvironmentResearch labs, biotech startups, academic collaborationsManufacturing facilities, quality control labs, biotech companies

Upstream Bio primarily involves early research and target identification, while Downstream Bio focuses on product development and manufacturing processes. Both roles require strong backgrounds in biology or chemistry, but they differ in their specific focus areas and work environments. Understanding these differences helps professionals choose the right career path within the biotech industry.

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Upstream Bio jobs near you
Infographic showing various Upstream Bio job openings in the United States as of August 2026, with employment types broken down into 2% As Needed, 83% Full Time, 12% Part Time, and 3% Contract. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $59,773 per year, or $28.7 per hour.

Upstream Senior Scientist, Process Development

Wheeler Bio, Inc.

Oklahoma City, OK

$84K - $116K/yr

Full-time

Re-posted 11 days ago

Job description

As an upstream Process Development Senior Scientist, you will support the development, optimization, and scale-up of mammalian upstream bioprocesses for the manufacture of biologic drug substances. You will contribute to the design and execution of laboratory experiments, data analysis, and technical documentation.

Key Responsibilities:

·                     Perform laboratory experiments to support mammalian upstream (cell culture) process development.

·                     Utilize Design of Experiments (DoE) for data analysis and experimental design.

·                     Assist in the optimization of upstream bioprocess parameters for yield, purity, and product quality attributes, collaborating with downstream, analytical and formulation teams.

·                     Support scale-up and technology transfer of processes to manufacturing or pilot facilities based on engineering principles including oxygen transfer.

·                     Work cross-functionally with analytical development, MSAT, manufacturing and quality teams to drive successful technology transfer.

·                     Prepare buffers, media, and other solutions according to SOPs and protocols.

·                     Operate and maintain flask and bioreactor equipment.

·                     Collect, analyze, and interpret experimental data; maintain accurate lab records and electronic notebooks.

·                     Present findings in internal and client meetings.

·                     Author technical reports and regulatory documentation.

·                     Complete Root Cause Analyses as needed, implementing corrective and preventative actions as needed.

·                     Mentor junior scientists and research associates in daily activities, data trending and data analysis.

·                     Follow all safety, quality, and compliance requirements.

Qualifications:

Education:

·                     Bachelor's, master's or PhD degree in Chemical Engineering, Biochemistry, Biotechnology, Biology, or related field.

Experience:

·                     5 - 12 years of hands-on experience in a bioprocessing or biopharmaceutical development environment (academic or industrial); some education qualifications may substitute for some years of experience.

·                     Experience in a CDMO environment is required.

·                     Experience with suspension mammalian cell culture and stirred tank bioreactors is required.

·                     Knowledge of protein purification and analytical techniques is a plus.

Skills and Knowledge:

·                     Understanding of cGMP, GLP, or other regulatory standards (preferred).

·                     Strong analytical and problem-solving skills.

·                     Good written and verbal communication skills.

·                     Ability to work both independently and in a collaborative team environment.