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Upstream Bio Jobs (NOW HIRING)

Vor Bio

Senior Accountant

Boston, MA · On-site

$110K - $135K/yr

... upstream survival signals and stopping downstream autoimmune cascades. Together, we are addressing ... Vor Bio is seeking a motivated Senior Accountant to join a growing and dynamic team. As a key ...

RWDC Industries

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Bioprocessing Manufacturing Technician

Winder, GA · On-site

$45K - $46K/yr

... upstream processing equipment. Specific Duties Include: * Serve as a valuable member of the ... Our biopolymers are bio-based and made from renewable resources that are biodegradable and ...

RWDC Industries

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Bioprocessing Manufacturing Technician

Athens, GA · On-site

$45K - $46K/yr

... upstream processing equipment. Specific Duties Include: * Serve as a valuable member of the ... Our biopolymers are bio-based and made from renewable resources that are biodegradable and ...

Elanco

Bio Manufacturing Operator

Elwood, KS

$17 - $20.25/hr

Execute and monitor core mAb manufacturing processes (media/buffer prep, upstream/downstream processing, formulation, fill/finish, secondary packaging). * Maintain cGMP compliance in a regulated ...

Getinge

Territory Manager, Bioprocessing

New York, NY · On-site

... bio-chemicals and bio-plastics for Industrial Biotechnology. Apply the knowledge of the ... Assists customers through the entire upstream process, from initial screening up to full-scale ...

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Upstream Bio information

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$29K

$59.8K

$109K

How much do upstream bio jobs pay per year?

As of Jul 3, 2026, the average yearly pay for upstream bio in the United States is $59,773.00, according to ZipRecruiter salary data. Most workers in this role earn between $42,500.00 and $70,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Upstream Bioprocessing Scientist, and why are they important?

To thrive as an Upstream Bioprocessing Scientist, you need a strong background in biology, chemistry, and biochemical engineering, typically supported by a degree in a related field. Experience with bioreactors, cell culture systems, process optimization, and familiarity with GMP regulations and analytical tools are essential. Problem-solving, teamwork, and attention to detail are crucial soft skills for excelling in complex laboratory environments. These competencies ensure efficient development and scaling of biologics production, directly impacting product quality and regulatory compliance.

What is an Upstream Bio scientist?

An Upstream Bio scientist focuses on the early stages of bioprocessing, specifically cultivating and optimizing the growth of cells or microorganisms to produce desired biological products such as proteins or antibodies. Their work includes developing cell lines, optimizing culture conditions, scaling up processes from laboratory to industrial scale, and ensuring high yields and quality. Upstream Bio scientists play a critical role in biotechnology, pharmaceuticals, and biomanufacturing, working closely with downstream processing teams to ensure efficient and successful product development.

What are the typical daily responsibilities of an upstream bioprocessing professional in a biotechnology company?

Upstream bioprocessing professionals typically focus on cultivating and optimizing cell cultures to produce biological products such as proteins or vaccines. Daily tasks often include preparing media, monitoring bioreactor parameters, sampling and analyzing cell growth, and troubleshooting process deviations. Collaboration with downstream processing teams and quality control is frequent to ensure seamless handoff and product quality. Additionally, maintaining detailed records and contributing to process improvement initiatives are key parts of the role.

What is the difference between Upstream Bio vs Downstream Bio?

AspectUpstream BioDownstream Bio
Focus AreaEarly-stage research, target discovery, molecular biologyProduct development, manufacturing, formulation
Required CredentialsBiochemistry, molecular biology, cell biology degreesBiochemistry, pharmaceutical sciences, chemical engineering degrees
Work EnvironmentResearch labs, biotech startups, academic collaborationsManufacturing facilities, quality control labs, biotech companies

Upstream Bio primarily involves early research and target identification, while Downstream Bio focuses on product development and manufacturing processes. Both roles require strong backgrounds in biology or chemistry, but they differ in their specific focus areas and work environments. Understanding these differences helps professionals choose the right career path within the biotech industry.

More about Upstream Bio jobs
What cities are hiring for Upstream Bio jobs? Cities with the most Upstream Bio job openings:
What states have the most Upstream Bio jobs? States with the most job openings for Upstream Bio jobs include:
What job categories do people searching Upstream Bio jobs look for? The top searched job categories for Upstream Bio jobs are:
Upstream Bio jobs near you
Infographic showing various Upstream Bio job openings in the United States as of June 2026, with employment types broken down into 1% Internship, 2% As Needed, 80% Full Time, 14% Part Time, and 3% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $59,773 per year, or $28.7 per hour.
Director/Senior Director of Asset Quality Assurance

Director/Senior Director of Asset Quality Assurance

Formation Bio

Boston, NY • On-site

$235K - $307K/yr

Other

Posted 27 days ago

Job description

About the Position 

Formation Bio is an AI native Biotech company running drug development programs, and the Quality function here is built to match that operating model: lean, risk-calibrated, and embedded in asset decisions from day one. You will not be maintaining a compliance bureaucracy; you will be designing quality frameworks that accelerate programs rather than slow them down. This is a rare seat at the table where quality strategy directly shapes how assets move forward and get to patients.

Responsibilities

  • Embed Quality by Design (QbD): Partner with asset development teams upstream to integrate Quality by Design principles into clinical, nonclinical, and CMC development plans, including those leveraging AI-enabled technology and real-world data.
  • Risk & Opportunity Mapping: Proactively identify meaningful quality risks and opportunities within assigned Asset Pods and collaborate with technical and strategic subject matter experts to establish fit-for-purpose control and mitigation strategies.
  • In-Licensing & Asset Due Diligence: Assess the quality health of external target assets during due diligence, including data quality and reliability, compliance risks, and vendor footprint.
  • Acquisition & Commercial Readiness: Drive the audit-readiness strategy to ensure assets transition seamlessly from development toward commercial launch or out-licensing.
  • Regulatory & Audit Intelligence: Interpret and apply global regulatory expectations (FDA, EMA, ICH) in digital and AI-accelerated environments, applying first-principles thinking to build fit-for-purpose, lean compliance frameworks for asset development and commercialization.

About You

  • You have a proven ability to influence and lead cross-functional Asset Pods and senior stakeholders without direct operational authority.
  • You apply first-principles thinking to bypass rigid compliance mentalities in favor of risk-benefit-based, agile problem solving.
  • You are fluent working with data-driven teams and comfortable leveraging automation and digital tools to maximize data value and process efficiency.
  • You have deep knowledge of the critical transitions an asset makes between preclinical and clinical phases through commercial or acquisition readiness, with well-rounded GxP proficiency across GLP, GCP, and GMP.
  • You have demonstrated skill in conducting quality due diligence assessments for R&D and early-stage clinical assets, and a deep understanding of requirements for commercialization inspections, product launch, and post-approval commitments.
  • You hold a bachelor's or advanced degree in a scientific, engineering, or related discipline, with extensive multidisciplinary GxP experience in biopharma quality assurance leadership, ideally within a fast-paced biotech that has successfully transitioned from early-stage to commercial.
  • You have a proven track record of managing program-level risk management frameworks and successfully leading assets through major regulatory inflection points and strategic transactions.

Total Compensation Range: Director $177,500 - $232,000; Senior Director $235,000 - $307,000

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