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Production Manager, Upstream

Athens, GA · On-site

UPSTREAM PRODUCTION MANAGER Reports to: Plant Manager Position Location: Athens, GA Job Summary ... Our biopolymers are bio-based and made from renewable resources that are biodegradable and ...

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ZYLIDAC BIO LLC

Director, cGMP Manufacturing

Emeryville, CA · On-site

$220K - $250K/yr

Zylidac Bio LLC is seeking a Director of cGMP Manufacturing. This position is a senior leadership ... This role oversees buffer preparation, media preparation, upstream and downstream drug substance ...

MSD

Scientist, Bio Process

West Point, PA · On-site

Our vaccines upstream process development team develops safe, scalable, robust, cost-effective upstream processes that enable clinical and commercial manufacture of vaccines and adjuvants across all ...

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$29K

$59.8K

$109K

How much do upstream bio jobs pay per year?

As of Jun 5, 2026, the average yearly pay for upstream bio in the United States is $59,773.00, according to ZipRecruiter salary data. Most workers in this role earn between $42,500.00 and $70,000.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Upstream Bioprocessing Scientist, and why are they important?

To thrive as an Upstream Bioprocessing Scientist, you need a strong background in biology, chemistry, and biochemical engineering, typically supported by a degree in a related field. Experience with bioreactors, cell culture systems, process optimization, and familiarity with GMP regulations and analytical tools are essential. Problem-solving, teamwork, and attention to detail are crucial soft skills for excelling in complex laboratory environments. These competencies ensure efficient development and scaling of biologics production, directly impacting product quality and regulatory compliance.

What is an Upstream Bio scientist?

An Upstream Bio scientist focuses on the early stages of bioprocessing, specifically cultivating and optimizing the growth of cells or microorganisms to produce desired biological products such as proteins or antibodies. Their work includes developing cell lines, optimizing culture conditions, scaling up processes from laboratory to industrial scale, and ensuring high yields and quality. Upstream Bio scientists play a critical role in biotechnology, pharmaceuticals, and biomanufacturing, working closely with downstream processing teams to ensure efficient and successful product development.

What are the typical daily responsibilities of an upstream bioprocessing professional in a biotechnology company?

Upstream bioprocessing professionals typically focus on cultivating and optimizing cell cultures to produce biological products such as proteins or vaccines. Daily tasks often include preparing media, monitoring bioreactor parameters, sampling and analyzing cell growth, and troubleshooting process deviations. Collaboration with downstream processing teams and quality control is frequent to ensure seamless handoff and product quality. Additionally, maintaining detailed records and contributing to process improvement initiatives are key parts of the role.

What is the difference between Upstream Bio vs Downstream Bio?

AspectUpstream BioDownstream Bio
Focus AreaEarly-stage research, target discovery, molecular biologyProduct development, manufacturing, formulation
Required CredentialsBiochemistry, molecular biology, cell biology degreesBiochemistry, pharmaceutical sciences, chemical engineering degrees
Work EnvironmentResearch labs, biotech startups, academic collaborationsManufacturing facilities, quality control labs, biotech companies

Upstream Bio primarily involves early research and target identification, while Downstream Bio focuses on product development and manufacturing processes. Both roles require strong backgrounds in biology or chemistry, but they differ in their specific focus areas and work environments. Understanding these differences helps professionals choose the right career path within the biotech industry.

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Upstream Bio jobs near you
Infographic showing various Upstream Bio job openings in the United States as of May 2026, with employment types broken down into 2% As Needed, 79% Full Time, 16% Part Time, 1% Temporary, and 2% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $59,773 per year, or $28.7 per hour.
Upstream Process Development

Upstream Process Development

Integrated Resources INC

South Plainfield, NJ • On-site

Full-time

Posted 15 days ago

Job description

Company Description

A Few Words About Us Integrated Resources, Inc is a premier staffing firm recognized as one of the tri-states most well-respected professional specialty firms. IRI has built its reputation on excellent service and integrity since its inception in 1996. Our mission centers on delivering only the best quality talent, the first time and every time. We provide quality resources in four specialty areas: Information Technology (IT), Clinical Research, Rehabilitation Therapy and Nursing.

Job Description

Upstream Process Development Scientist

Experience in development of mammalian cell culture processes for the production of recombinant proteins is a plus. Knowledge of protein chemistry and purification techniques and purification process development experience is preferred. Basic knowledge of cGMP policies and procedures. Basic knowledge of regulatory requirements of the pharmaceutical / biotechnology industry.


Key Responsibilities:

Design and execute experiments for production of proteins using microbial fermentation processes.      Design, analyze and interpret lab experiments, purification data, in-process trends, productivity and quality attributes to support upstream process development.

Lead efforts to evaluate different fermentation media, feeds, and feeding strategies to improve product yield and quality including proper folding of protein

Scale up process developed at research stage to manufacture adequate amounts of protein to support clinical trials

Author technical documentation including process validation protocols and reports.

Evaluate process robustness, investigate causes of process variances, and take steps to maximize process reproducibility.

Qualifications

Basic qualifications: Ph.D., MS or BS in Chemical/Biochemical Engineering or related Biological Sciences is required. For a candidate with a Ph.D. >3 yrs. of industrial experience; candidate with an MS >5 yrs. industrial experience and for a candidate with a BS, >7 years of industrial experience in developing upstream microbial fermentation processes for the production of bio-pharmaceuticals is required. Specific experience in development of microbial expression processes for soluble protein production is preferred.

Additional Information



 

Integrated Resources logo

About Integrated Resources

Sourced by ZipRecruiter

Integrated Resources Inc (IRI), based in Edison, NJ, US, is an esteemed player in the staffing solutions industry with a credible presence on their official website irionline.com. Notably, IRI provides a range of professional staffing services including contract, contract-to-hire, and direct hire solutions to a wide spectrum of industries such as healthcare, life sciences, manufacturing, financial, insurance, and others. Since its inception, IRI has been committed to delivering top-talent and optimum solutions to meet its clients' diverse needs.

Industry

Recruiting and staffing services

Company size

51 - 200 Employees

Headquarters location

Edison, NJ, US

Year founded

1996

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