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Downstream Manufacturing Jobs (NOW HIRING)

Kinetic Personnel Group

Manufacturing Associate

Tustin, CA ยท On-site

Downstream Manufacturing Associate Location: [Insert Location] Department: Manufacturing รขย€ย“ Downstream Operations Employment Type: Full-Time Position Summary We are seeking a motivated Downstream ...

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How much do downstream manufacturing jobs pay per hour?

As of Jul 19, 2026, the average hourly pay for downstream manufacturing in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in Downstream Manufacturing, and why are they important?

To thrive in Downstream Manufacturing, you need a solid understanding of biochemical processes, purification techniques, and quality control standards, often supported by a background in biotechnology, chemistry, or chemical engineering. Familiarity with process automation systems, chromatography equipment, and GMP (Good Manufacturing Practice) certification is commonly required. Attention to detail, strong problem-solving abilities, and effective teamwork are vital soft skills in this field. These skills ensure efficient production, product purity, regulatory compliance, and successful collaboration in biomanufacturing environments.

What is the difference between Downstream Manufacturing vs Upstream Manufacturing?

AspectDownstream ManufacturingUpstream Manufacturing
FocusProcessing and finishing products after initial productionRaw material extraction and initial production processes
Work EnvironmentFactories, chemical plants, refineriesMining sites, raw material processing facilities
Common CertificationsProcess Safety Management, OSHA certificationsMining safety certifications, OSHA
Industry UsagePetroleum, chemicals, pharmaceuticalsMining, raw material extraction

Downstream Manufacturing involves processing and finishing products after initial production, often in chemical plants or refineries. Upstream Manufacturing focuses on raw material extraction and initial processing, such as mining or crude oil extraction. Both roles are essential in the supply chain but differ in their focus, environment, and certifications.

What is downstream manufacturing?

Downstream manufacturing refers to the processes involved in the purification and formulation of products after the initial production phase, particularly in industries like biotechnology and pharmaceuticals. It typically includes steps such as separation, purification, and packaging of biomolecules or chemicals produced during upstream processes like fermentation or cell culture. The goal of downstream manufacturing is to ensure that the final product meets quality, safety, and regulatory standards before distribution to the market.

What are some common challenges faced in Downstream Manufacturing roles and how can they be addressed?

Professionals in Downstream Manufacturing often encounter challenges such as maintaining product purity, optimizing yield, and troubleshooting equipment issues during purification processes. Adapting to rapidly changing production schedules and ensuring compliance with strict regulatory standards can also pose difficulties. Effective solutions include thorough training in process controls, routine equipment maintenance, and strong collaboration with quality assurance and upstream teams to streamline workflows and address issues proactively.
More about Downstream Manufacturing jobs
What states have the most Downstream Manufacturing jobs? States with the most job openings for Downstream Manufacturing jobs include:
What job categories do people searching Downstream Manufacturing jobs look for? The top searched job categories for Downstream Manufacturing jobs are:
Downstream Manufacturing jobs near you
Infographic showing various Downstream Manufacturing job openings in the United States as of July 2026, with employment types broken down into 96% Full Time, 1% Part Time, and 3% Contract. Highlights an 85% Physical, 4% Hybrid, and 11% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Downstream Manufacturing Associate

Global Life Science Hub

Piscataway, NJ โ€ข On-site

Other

Posted 8 days ago

Job description

DOWNSTREAM MANUFACTURING ASSOCIATE Piscataway, NJ - Full-Time, Permanent

We are seeking a Downstream Manufacturing Associate to join a well-established biologics manufacturer in Piscataway, NJ. This is a full-time permanent position - not a contract role.


You will be executing cGMP downstream purification processes at scale, working across engineering, clinical, and commercial batches in a regulated manufacturing environment. Hands-on, production floor work with real responsibility from day one.


What you'll be doing:

  • Executing downstream purification processes at 50L to 1000L scale in a cGMP environment
  • Operating and maintaining AKTA purification skids, TFF systems, and chromatography equipment
  • Column packing, process troubleshooting, and data analysis
  • Initiating and completing batch records, deviations, and investigations in line with GMP requirements
  • Supporting environmental health and safety compliance on the manufacturing floor


What you need:

  • 1-2+ years hands-on experience in downstream cGMP manufacturing within biopharma or a CDMO
  • Experience with AKTA or equivalent purification systems and TFF
  • Mammalian cell culture or biologics manufacturing background
  • Comfortable with GMP documentation - batch records, protocols, investigations
  • BS or MS in biochemistry, biotech, chemical or biological sciences


Multiple levels available - MFG I, II, and III - so we are open to candidates across the experience spectrum.

If this sounds like your next move, apply directly or reach out to discuss.

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