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Downstream Manufacturing Jobs (NOW HIRING)

Kinetic Personnel Group

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Supervisor, Manufacturing - Downstream

Irvine, CA · On-site

$75K - $95K/yr

Supervisor, Manufacturing - Downstream Salary: $75,000 - $95,000 Position Summary The Supervisor, Manufacturing - Downstream is responsible for leading downstream manufacturing operations and ...

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How much do downstream manufacturing jobs pay per hour?

As of Jun 29, 2026, the average hourly pay for downstream manufacturing in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What job makes $10,000 a month without a degree?

In downstream manufacturing, roles such as experienced plant managers or specialized technical supervisors can earn around $10,000 per month without a college degree, especially with extensive industry experience and certifications. High-paying positions often require strong technical skills, leadership abilities, and knowledge of manufacturing processes and safety protocols.

What are the key skills and qualifications needed to thrive in Downstream Manufacturing, and why are they important?

To thrive in Downstream Manufacturing, you need a solid understanding of biochemical processes, purification techniques, and quality control standards, often supported by a background in biotechnology, chemistry, or chemical engineering. Familiarity with process automation systems, chromatography equipment, and GMP (Good Manufacturing Practice) certification is commonly required. Attention to detail, strong problem-solving abilities, and effective teamwork are vital soft skills in this field. These skills ensure efficient production, product purity, regulatory compliance, and successful collaboration in biomanufacturing environments.

What is the difference between Downstream Manufacturing vs Upstream Manufacturing?

AspectDownstream ManufacturingUpstream Manufacturing
FocusProcessing and finishing products after initial productionRaw material extraction and initial production processes
Work EnvironmentFactories, chemical plants, refineriesMining sites, raw material processing facilities
Common CertificationsProcess Safety Management, OSHA certificationsMining safety certifications, OSHA
Industry UsagePetroleum, chemicals, pharmaceuticalsMining, raw material extraction

Downstream Manufacturing involves processing and finishing products after initial production, often in chemical plants or refineries. Upstream Manufacturing focuses on raw material extraction and initial processing, such as mining or crude oil extraction. Both roles are essential in the supply chain but differ in their focus, environment, and certifications.

What is downstream manufacturing?

Downstream manufacturing refers to the processes involved in the purification and formulation of products after the initial production phase, particularly in industries like biotechnology and pharmaceuticals. It typically includes steps such as separation, purification, and packaging of biomolecules or chemicals produced during upstream processes like fermentation or cell culture. The goal of downstream manufacturing is to ensure that the final product meets quality, safety, and regulatory standards before distribution to the market.

What jobs pay $500,000 a year in the US?

In downstream manufacturing, executive roles such as plant managers, operations directors, or senior engineers with extensive experience and specialized skills can reach or exceed $500,000 annually, especially in large companies or with bonuses and stock options. High-level positions often require advanced degrees, certifications, and a strong track record in process optimization, safety, and leadership.

What jobs pay 2000 a day?

In downstream manufacturing, high-paying roles such as plant managers, process engineers, or specialized technical consultants can earn around $2,000 per day, especially with extensive experience, certifications, and working in large-scale facilities. These positions often require advanced skills, leadership abilities, and knowledge of manufacturing processes or safety standards.

What is the highest paying job in manufacturing?

In downstream manufacturing, roles such as manufacturing plant managers, engineering directors, and specialized process engineers tend to be among the highest paid. These positions often require extensive experience, advanced technical skills, and sometimes certifications, with salaries varying based on company size and location.

What are some common challenges faced in Downstream Manufacturing roles and how can they be addressed?

Professionals in Downstream Manufacturing often encounter challenges such as maintaining product purity, optimizing yield, and troubleshooting equipment issues during purification processes. Adapting to rapidly changing production schedules and ensuring compliance with strict regulatory standards can also pose difficulties. Effective solutions include thorough training in process controls, routine equipment maintenance, and strong collaboration with quality assurance and upstream teams to streamline workflows and address issues proactively.
More about Downstream Manufacturing jobs
What states have the most Downstream Manufacturing jobs? States with the most job openings for Downstream Manufacturing jobs include:
What job categories do people searching Downstream Manufacturing jobs look for? The top searched job categories for Downstream Manufacturing jobs are:
Downstream Manufacturing jobs near you

Downstream Manufacturing Associate

Global Life Science Hub

Piscataway, NJ • On-site

Other

Posted 18 days ago

Key responsibilities

  • Execute downstream purification processes at 50L to 1000L scale in a cGMP environment.

  • Operate and maintain AKTA purification skids, TFF systems, and chromatography equipment.

  • Initiate and complete batch records, deviations, and investigations in line with GMP requirements.

Job description

DOWNSTREAM MANUFACTURING ASSOCIATE Piscataway, NJ - Full-Time, Permanent

We are seeking a Downstream Manufacturing Associate to join a well-established biologics manufacturer in Piscataway, NJ. This is a full-time permanent position - not a contract role.


You will be executing cGMP downstream purification processes at scale, working across engineering, clinical, and commercial batches in a regulated manufacturing environment. Hands-on, production floor work with real responsibility from day one.


What you'll be doing:

  • Executing downstream purification processes at 50L to 1000L scale in a cGMP environment
  • Operating and maintaining AKTA purification skids, TFF systems, and chromatography equipment
  • Column packing, process troubleshooting, and data analysis
  • Initiating and completing batch records, deviations, and investigations in line with GMP requirements
  • Supporting environmental health and safety compliance on the manufacturing floor


What you need:

  • 1-2+ years hands-on experience in downstream cGMP manufacturing within biopharma or a CDMO
  • Experience with AKTA or equivalent purification systems and TFF
  • Mammalian cell culture or biologics manufacturing background
  • Comfortable with GMP documentation - batch records, protocols, investigations
  • BS or MS in biochemistry, biotech, chemical or biological sciences


Multiple levels available - MFG I, II, and III - so we are open to candidates across the experience spectrum.

If this sounds like your next move, apply directly or reach out to discuss.

Apply