ZipRecruiter

Log In

1

Downstream Manufacturing Jobs (NOW HIRING)

A-Line Staffing Solutions

Be Seen First

Manufacturing Maintenance Technician

Sumter, SC · On-site

$22.50/hr

Support upstream and downstream manufacturing operations * Perform rework activities as required * Work collaboratively within a team environment * Complete additional duties as assigned by ...

New

Alamar Biosciences

Manufacturing Associate I

Fremont, CA · On-site

$25 - $35/hr

Perform standardized antibodies dispensing and support lyophilization of critical components for downstream manufacturing. * Assist in other areas of manufacturing deemed high priority such as ...

Lonza

MSAT Process Engineer

Portsmouth, NH · On-site

$106K - $137K/yr

Our Sr. Process Engineer's primary responsibility is to be a process owner and primary technical Subject Matter Expert (SME) for downstream manufacturing processes. This person should have experience ...

Actalent

Associate Manufacturing

Holly Springs, NC

$20/hr

Preferred experience in Downstream Manufacturing or Drug Substance Manufacturing. Work Environment The work schedule follows a 12-hour, 2-2-3 rotating shift based on the production schedule. The role ...

next page

Showing results 1-20

People also search for

All JobsDownstream Manufacturing Jobs

Downstream Manufacturing information

See salary details

$13

$24

$34

How much do downstream manufacturing jobs pay per hour?

As of Jun 7, 2026, the average hourly pay for downstream manufacturing in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in Downstream Manufacturing, and why are they important?

To thrive in Downstream Manufacturing, you need a solid understanding of biochemical processes, purification techniques, and quality control standards, often supported by a background in biotechnology, chemistry, or chemical engineering. Familiarity with process automation systems, chromatography equipment, and GMP (Good Manufacturing Practice) certification is commonly required. Attention to detail, strong problem-solving abilities, and effective teamwork are vital soft skills in this field. These skills ensure efficient production, product purity, regulatory compliance, and successful collaboration in biomanufacturing environments.

What is the difference between Downstream Manufacturing vs Upstream Manufacturing?

AspectDownstream ManufacturingUpstream Manufacturing
FocusProcessing and finishing products after initial productionRaw material extraction and initial production processes
Work EnvironmentFactories, chemical plants, refineriesMining sites, raw material processing facilities
Common CertificationsProcess Safety Management, OSHA certificationsMining safety certifications, OSHA
Industry UsagePetroleum, chemicals, pharmaceuticalsMining, raw material extraction

Downstream Manufacturing involves processing and finishing products after initial production, often in chemical plants or refineries. Upstream Manufacturing focuses on raw material extraction and initial processing, such as mining or crude oil extraction. Both roles are essential in the supply chain but differ in their focus, environment, and certifications.

What is downstream manufacturing?

Downstream manufacturing refers to the processes involved in the purification and formulation of products after the initial production phase, particularly in industries like biotechnology and pharmaceuticals. It typically includes steps such as separation, purification, and packaging of biomolecules or chemicals produced during upstream processes like fermentation or cell culture. The goal of downstream manufacturing is to ensure that the final product meets quality, safety, and regulatory standards before distribution to the market.

What are some common challenges faced in Downstream Manufacturing roles and how can they be addressed?

Professionals in Downstream Manufacturing often encounter challenges such as maintaining product purity, optimizing yield, and troubleshooting equipment issues during purification processes. Adapting to rapidly changing production schedules and ensuring compliance with strict regulatory standards can also pose difficulties. Effective solutions include thorough training in process controls, routine equipment maintenance, and strong collaboration with quality assurance and upstream teams to streamline workflows and address issues proactively.
More about Downstream Manufacturing jobs
What states have the most Downstream Manufacturing jobs? States with the most job openings for Downstream Manufacturing jobs include:
What job categories do people searching Downstream Manufacturing jobs look for? The top searched job categories for Downstream Manufacturing jobs are:
Downstream Manufacturing jobs near you
Infographic showing various Downstream Manufacturing job openings in the United States as of May 2026, with employment types broken down into 100% Full Time. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Senior Manufacturing Associate, Downstream

TANVEX BIOPHARMA USA INC

San Diego, CA • On-site

$75K - $90K/yr

Full-time

Posted 28 days ago

Job description

Description:

SUMMARY


Under general supervision, the Senior Manufacturing Associate, Downstream, will perform routine manufacturing activities in GMP manufacturing areas including purification and the associated sub-processes/ preparation. Operations will be performed according to Standard Operating Procedures (SOPs) and batch records. Perform manufacturing steps, execute routine batch records, and revise documents such as batch records and SOPs as needed. Drives projects and assignments and provides mentorship to associates. Flexible shift schedule and overtime may be required.


JOB RESPONSIBILITIES


Technical:

? Perform moderately complex tasks using defined protocols or procedures which contribute to the achievement of project milestones.

? Perform GMP manufacturing activities in assigned areas.

? Set-up, operate, maintain and clean downstream bioprocessing equipment, which includes but is not limited to chromatography systems, UF/DF and Viral filtration skids and mixers.

? Perform basic troubleshooting of bioprocess equipment.

? Perform manual cleaning and sterilization of manufacturing areas, parts and components.

Compliance:

? Follow Standard Operating Procedures (SOPs), current Good Manufacturing Practices (cGMPs), plant safety guidelines and other established procedures during the manufacturing process to produce quality products.

? Accurately complete and maintain detail-oriented process-related documentation of equipment logs and batch records following the manufacturing Good Documentation Practices (GDP).

? Draft and revise SOPs and batch records.

Teamwork and Communication:

? Participate in regularly scheduled team meetings to discuss ideas, troubleshoot issues, go over lessons learned and identify future projects or tasks.

? May provide mentoring and coaching to colleagues, team members, or those with similar or less experience

? Act as Lead when Specialist/Supervisor is unavailable.

? Address production issues and report any compliance related concerns to supervisor and/or management as soon as possible.

? Fosters teamwork and is expected to suggest project improvements.


JOB REQUIREMENTS


Education and Experience


? Advanced degree in life sciences or related discipline with 3 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.

? Bachelor's degree with 6 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.

? High School Diploma/GED with 8 years of experience in the pharmaceutical or biotech industry, or equivalent education and experience.


Knowledge, Skills and Abilities:


? Downstream/Purification experience and skills in Protein Chromatography, TFF, Depth Filtration, Viral Filtration, Bulk Drug Substance Formulation, and Final Filtration. Aseptic Sampling of process pools and buffers. Buffer Preparation, Tubing assemblies and Autoclaving Operations.

? Knowledge of UNICORN and Common Control Platform (CCP) Software is preferred.

? Fundamental knowledge of current biologics regulations and cGMP for drug substance operation.

? Proficient with Microsoft Word and Excel.

? Able to work with pressurized systems, steam, and corrosive chemicals with necessary safety precautions.

? Demonstrated ability to follow and document activities in written procedures and/or logbooks.

? Detail-oriented, strong team player.

? Effective collaboration skills and the ability to work cross functionally across categories and internal stakeholders.

Requirements: