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Downstream Manufacturing Jobs (NOW HIRING)

Sanofi EU

Manufacturing Excellence Manager

Yonkers, NY · On-site

Oversee downstream operations including purification and buffer preparation * Ensure all manufacturing activities comply with GMP regulations and internal quality standards * Serve as a technical ...

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How much do downstream manufacturing jobs pay per hour?

As of Jun 29, 2026, the average hourly pay for downstream manufacturing in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What job makes $10,000 a month without a degree?

In downstream manufacturing, roles such as experienced plant managers or specialized technical supervisors can earn around $10,000 per month without a college degree, especially with extensive industry experience and certifications. High-paying positions often require strong technical skills, leadership abilities, and knowledge of manufacturing processes and safety protocols.

What are the key skills and qualifications needed to thrive in Downstream Manufacturing, and why are they important?

To thrive in Downstream Manufacturing, you need a solid understanding of biochemical processes, purification techniques, and quality control standards, often supported by a background in biotechnology, chemistry, or chemical engineering. Familiarity with process automation systems, chromatography equipment, and GMP (Good Manufacturing Practice) certification is commonly required. Attention to detail, strong problem-solving abilities, and effective teamwork are vital soft skills in this field. These skills ensure efficient production, product purity, regulatory compliance, and successful collaboration in biomanufacturing environments.

What is the difference between Downstream Manufacturing vs Upstream Manufacturing?

AspectDownstream ManufacturingUpstream Manufacturing
FocusProcessing and finishing products after initial productionRaw material extraction and initial production processes
Work EnvironmentFactories, chemical plants, refineriesMining sites, raw material processing facilities
Common CertificationsProcess Safety Management, OSHA certificationsMining safety certifications, OSHA
Industry UsagePetroleum, chemicals, pharmaceuticalsMining, raw material extraction

Downstream Manufacturing involves processing and finishing products after initial production, often in chemical plants or refineries. Upstream Manufacturing focuses on raw material extraction and initial processing, such as mining or crude oil extraction. Both roles are essential in the supply chain but differ in their focus, environment, and certifications.

What is downstream manufacturing?

Downstream manufacturing refers to the processes involved in the purification and formulation of products after the initial production phase, particularly in industries like biotechnology and pharmaceuticals. It typically includes steps such as separation, purification, and packaging of biomolecules or chemicals produced during upstream processes like fermentation or cell culture. The goal of downstream manufacturing is to ensure that the final product meets quality, safety, and regulatory standards before distribution to the market.

What jobs pay $500,000 a year in the US?

In downstream manufacturing, executive roles such as plant managers, operations directors, or senior engineers with extensive experience and specialized skills can reach or exceed $500,000 annually, especially in large companies or with bonuses and stock options. High-level positions often require advanced degrees, certifications, and a strong track record in process optimization, safety, and leadership.

What jobs pay 2000 a day?

In downstream manufacturing, high-paying roles such as plant managers, process engineers, or specialized technical consultants can earn around $2,000 per day, especially with extensive experience, certifications, and working in large-scale facilities. These positions often require advanced skills, leadership abilities, and knowledge of manufacturing processes or safety standards.

What is the highest paying job in manufacturing?

In downstream manufacturing, roles such as manufacturing plant managers, engineering directors, and specialized process engineers tend to be among the highest paid. These positions often require extensive experience, advanced technical skills, and sometimes certifications, with salaries varying based on company size and location.

What are some common challenges faced in Downstream Manufacturing roles and how can they be addressed?

Professionals in Downstream Manufacturing often encounter challenges such as maintaining product purity, optimizing yield, and troubleshooting equipment issues during purification processes. Adapting to rapidly changing production schedules and ensuring compliance with strict regulatory standards can also pose difficulties. Effective solutions include thorough training in process controls, routine equipment maintenance, and strong collaboration with quality assurance and upstream teams to streamline workflows and address issues proactively.
More about Downstream Manufacturing jobs
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What job categories do people searching Downstream Manufacturing jobs look for? The top searched job categories for Downstream Manufacturing jobs are:
Downstream Manufacturing jobs near you

Senior Process Engineer - Downstream (Biologics & Peptides)

Stark Pharma Solutions Inc

Boulder, CO • On-site

$107K - $139K/yr

Contractor

Posted 19 days ago

Job description

Job Title: Senior Process Engineer – Downstream (Biologics & Peptides)

Location: Boulder, CO (100% Onsite)

Duration: 6 Months + Extensions

Start Date: ASAP

Job Summary

We are seeking a Senior Process Engineer with strong expertise in downstream processing to support the development, scale-up, and commercialization of biologics and peptide-based therapeutics. This role will focus on designing, optimizing, and implementing purification processes and manufacturing systems within a GMP-regulated environment.

The ideal candidate will have hands-on experience with chromatography and tangential flow filtration (TFF) technologies, along with a proven track record supporting process scale-up, equipment qualification, and manufacturing startup activities.

Key Responsibilities

  • Lead downstream process development and optimization activities for biologics and peptide products
  • Design, specify, and support implementation of purification systems including chromatography and TFF skids
  • Support process scale-up from development through pilot and commercial manufacturing
  • Drive startup, commissioning, qualification, and troubleshooting of downstream manufacturing equipment
  • Develop and execute process validation and verification strategies aligned with GMP and regulatory requirements
  • Collaborate with MSAT, Upstream, Manufacturing, and Quality teams to ensure process robustness and consistency
  • Author and review technical documentation including process descriptions, validation protocols, and regulatory support documents
  • Serve as a technical SME for downstream purification operations and technologies
  • Mentor junior engineers and support continuous improvement initiatives

Required Qualifications

  • Bachelor’s, Master’s, or PhD in Chemical Engineering, Biochemical Engineering, or related field
  • 8+ years of experience in biopharmaceutical process engineering with strong downstream processing expertise
  • Hands-on experience with:
  • Chromatography systems (affinity, ion exchange, HIC, etc.)
  • Tangential Flow Filtration (TFF) systems
  • Experience supporting equipment startup, commissioning, and qualification activities
  • Strong understanding of process validation and GMP manufacturing environments
  • Experience supporting or leading tech transfer and process scale-up activities
  • Strong troubleshooting, communication, and cross-functional collaboration skills