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Downstream Manufacturing Jobs in California (NOW HIRING)

Kinetic Personnel Group

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Upstream, Downstream and Formulation Openings

Tustin, CA · On-site

$20 - $21/hr

Upstream, Formulation & Downstream Manufacturing Associate Location: Tustin, CA Industry: Biopharmaceutical Manufacturing Schedule: Multiple Shifts Available Employment Type: Full-Time Position ...

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Downstream Manufacturing information

What is downstream manufacturing?

Downstream manufacturing refers to the processes involved in the purification and formulation of products after the initial production phase, particularly in industries like biotechnology and pharmaceuticals. It typically includes steps such as separation, purification, and packaging of biomolecules or chemicals produced during upstream processes like fermentation or cell culture. The goal of downstream manufacturing is to ensure that the final product meets quality, safety, and regulatory standards before distribution to the market.

What are the key skills and qualifications needed to thrive in downstream manufacturing?

To thrive in Downstream Manufacturing, you need a solid understanding of biochemical processes, purification techniques, and quality control standards, often supported by a background in biotechnology, chemistry, or chemical engineering. Familiarity with process automation systems, chromatography equipment, and GMP (Good Manufacturing Practice) certification is commonly required. Attention to detail, strong problem-solving abilities, and effective teamwork are vital soft skills in this field. These skills ensure efficient production, product purity, regulatory compliance, and successful collaboration in biomanufacturing environments.

What are some common challenges faced in downstream manufacturing roles and how can they be addressed?

Professionals in Downstream Manufacturing often encounter challenges such as maintaining product purity, optimizing yield, and troubleshooting equipment issues during purification processes. Adapting to rapidly changing production schedules and ensuring compliance with strict regulatory standards can also pose difficulties. Effective solutions include thorough training in process controls, routine equipment maintenance, and strong collaboration with quality assurance and upstream teams to streamline workflows and address issues proactively.

What is the difference between Downstream Manufacturing vs Upstream Manufacturing?

AspectDownstream ManufacturingUpstream Manufacturing
FocusProcessing and finishing products after initial productionRaw material extraction and initial production processes
Work EnvironmentFactories, chemical plants, refineriesMining sites, raw material processing facilities
Common CertificationsProcess Safety Management, OSHA certificationsMining safety certifications, OSHA
Industry UsagePetroleum, chemicals, pharmaceuticalsMining, raw material extraction

Downstream Manufacturing involves processing and finishing products after initial production, often in chemical plants or refineries. Upstream Manufacturing focuses on raw material extraction and initial processing, such as mining or crude oil extraction. Both roles are essential in the supply chain but differ in their focus, environment, and certifications.

What are popular job titles related to Downstream Manufacturing jobs in California?

For Downstream Manufacturing jobs in California, the most frequently searched job titles are:

What job categories do people searching Downstream Manufacturing jobs in California look for?

The top searched job categories for Downstream Manufacturing jobs in California are:

Downstream Manufacturing jobs near you
Infographic showing various Downstream Manufacturing job openings in California as of August 2026, with employment types broken down into 87% Full Time, 6% Part Time, 2% Temporary, 3% Contract, and 2% Nights. Highlights an 94% Physical, 3% Hybrid, and 3% Remote job distribution.

Upstream, Downstream and Formulation Openings

Kinetic Personnel Group

Tustin, CA • On-site

$20 - $21/hr

Full-time

Medical, Dental, Vision

Posted 4 days ago

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Job description

Upstream, Formulation & Downstream Manufacturing Associate

Location: Tustin, CA
Industry: Biopharmaceutical Manufacturing
Schedule: Multiple Shifts Available
Employment Type: Full-Time

Position Summary

A leading biopharmaceutical manufacturing company in Tustin, CA is seeking motivated Manufacturing Associates to support Upstream, Formulation, and Downstream manufacturing operations. These positions are responsible for executing manufacturing activities in a controlled GMP environment while following established procedures, safety requirements, and quality standards.

Multiple shifts are available, including 1st, 2nd, and 3rd shifts. Candidates with a degree in Biology, Biochemistry, Biotechnology, Microbiology, or another related Life Science discipline are encouraged to apply.

Key Responsibilities

Upstream Manufacturing

  • Support cell culture and upstream bioprocessing activities.
  • Prepare and stage materials, equipment, and solutions for manufacturing operations.
  • Assist with media and buffer preparation.
  • Monitor and document manufacturing processes and equipment readings.
  • Perform sampling and in-process testing as required.
  • Follow SOPs, batch records, GMP requirements, and safety procedures.
  • Maintain clean and organized manufacturing areas.
  • Accurately document manufacturing activities in accordance with GMP requirements.

Formulation Manufacturing

  • Support formulation and preparation of biopharmaceutical products.
  • Weigh, measure, and prepare raw materials and components according to approved procedures.
  • Operate manufacturing equipment following established SOPs.
  • Perform equipment setup, cleaning, and sanitization.
  • Conduct in-process checks and sampling.
  • Complete batch documentation and manufacturing records accurately.
  • Follow aseptic and GMP practices as required.

Downstream Manufacturing

  • Support downstream purification and processing activities.
  • Assist with filtration, chromatography, centrifugation, and related manufacturing processes.
  • Prepare and stage materials and equipment for production.
  • Monitor equipment and process parameters.
  • Collect and document process samples.
  • Perform equipment setup, cleaning, and sanitization.
  • Follow SOPs, batch records, GMP requirements, and safety procedures.

Qualifications

  • Bachelor's degree in Biology, Biochemistry, Biotechnology, Microbiology, Chemistry, or another related Life Science discipline required.
  • Manufacturing, laboratory, pharmaceutical, biotechnology, or biopharmaceutical experience preferred.
  • Understanding of basic biological and laboratory principles.
  • Ability to accurately follow written procedures and SOPs.
  • Strong attention to detail and documentation skills.
  • Ability to work effectively in a team-oriented manufacturing environment.
  • Ability to work multiple shifts, including evenings, nights, weekends, or overtime as required.
  • Ability to work in a controlled/GMP manufacturing environment.
  • Strong communication and organizational skills.
  • Ability to learn manufacturing equipment, processes, and procedures quickly.

Preferred Experience

  • GMP or cGMP experience.
  • Biopharmaceutical or pharmaceutical manufacturing experience.
  • Cell culture or upstream processing experience.
  • Formulation or solution preparation experience.
  • Downstream purification experience.
  • Experience with batch records and manufacturing documentation.
  • Experience working in a cleanroom or controlled manufacturing environment.

Physical Requirements

  • Ability to stand and walk for extended periods.
  • Ability to wear required PPE and cleanroom garments.
  • Ability to lift and move materials and equipment as required.
  • Ability to perform repetitive manufacturing activities.
  • Ability to work in a controlled manufacturing environment.

Why Join Us?

This is an excellent opportunity for a Life Science graduate to build hands-on experience in biopharmaceutical manufacturing and develop expertise across Upstream, Formulation, or Downstream processing. Successful candidates will work in a regulated GMP environment supporting the production of high-quality biopharmaceutical products.

Multiple shifts available. Apply today for immediate consideration.