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Downstream Manufacturing Jobs in California (NOW HIRING)

Kinetic Personnel Group

Be Seen First

Biopharmaceutical Manufacturing Associate

Tustin, CA · On-site

$20 - $21/hr

ob description Upstream, Formulation & Downstream Manufacturing Associate Location: Tustin, CA Industry: Biopharmaceutical Manufacturing Schedule: 5:00PM - 2:00AM Employment Type: Full-Time Position ...

New

Kinetic Personnel Group

Be Seen First

Biopharmaceutical Manufacturing Associate

Tustin, CA · On-site

$20 - $21/hr

ob description Upstream, Formulation & Downstream Manufacturing Associate Location: Tustin, CA Industry: Biopharmaceutical Manufacturing Schedule: 5:00PM - 2:00AM Employment Type: Full-Time Position ...

New

TekWissen LLC

Manufacturing Associate

Vacaville, CA · On-site

$25 - $28/hr

Support Downstream Manufacturing activities, including fixed tank and filtration system operations, large-scale buffer preparation, column chromatography operations, component dispensing, and ...

Fladger Associates

Batch Record Coordinator

Fremont, CA · On-site

$21.25 - $29/hr

Ensures BioMES Electronic Batch Record (EBR) Modelers draft EBRs on-time for Downstream Manufacturing processing. * Maintains detailed Batch Record Delivery Schedule & Tracker for each product ...

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Downstream Manufacturing information

What is downstream manufacturing?

Downstream manufacturing refers to the processes involved in the purification and formulation of products after the initial production phase, particularly in industries like biotechnology and pharmaceuticals. It typically includes steps such as separation, purification, and packaging of biomolecules or chemicals produced during upstream processes like fermentation or cell culture. The goal of downstream manufacturing is to ensure that the final product meets quality, safety, and regulatory standards before distribution to the market.

What are the key skills and qualifications needed to thrive in downstream manufacturing?

To thrive in Downstream Manufacturing, you need a solid understanding of biochemical processes, purification techniques, and quality control standards, often supported by a background in biotechnology, chemistry, or chemical engineering. Familiarity with process automation systems, chromatography equipment, and GMP (Good Manufacturing Practice) certification is commonly required. Attention to detail, strong problem-solving abilities, and effective teamwork are vital soft skills in this field. These skills ensure efficient production, product purity, regulatory compliance, and successful collaboration in biomanufacturing environments.

What are some common challenges faced in downstream manufacturing roles and how can they be addressed?

Professionals in Downstream Manufacturing often encounter challenges such as maintaining product purity, optimizing yield, and troubleshooting equipment issues during purification processes. Adapting to rapidly changing production schedules and ensuring compliance with strict regulatory standards can also pose difficulties. Effective solutions include thorough training in process controls, routine equipment maintenance, and strong collaboration with quality assurance and upstream teams to streamline workflows and address issues proactively.

What is the difference between Downstream Manufacturing vs Upstream Manufacturing?

AspectDownstream ManufacturingUpstream Manufacturing
FocusProcessing and finishing products after initial productionRaw material extraction and initial production processes
Work EnvironmentFactories, chemical plants, refineriesMining sites, raw material processing facilities
Common CertificationsProcess Safety Management, OSHA certificationsMining safety certifications, OSHA
Industry UsagePetroleum, chemicals, pharmaceuticalsMining, raw material extraction

Downstream Manufacturing involves processing and finishing products after initial production, often in chemical plants or refineries. Upstream Manufacturing focuses on raw material extraction and initial processing, such as mining or crude oil extraction. Both roles are essential in the supply chain but differ in their focus, environment, and certifications.

What are popular job titles related to Downstream Manufacturing jobs in California?

For Downstream Manufacturing jobs in California, the most frequently searched job titles are:

What job categories do people searching Downstream Manufacturing jobs in California look for?

The top searched job categories for Downstream Manufacturing jobs in California are:

Downstream Manufacturing jobs near you
Infographic showing various Downstream Manufacturing job openings in California as of August 2026, with employment types broken down into 89% Full Time, 7% Part Time, 2% Contract, and 2% Nights. Highlights an 94% Physical, 3% Hybrid, and 3% Remote job distribution.

Manufacturing Technical Specialist (Downstream)

Avid Bioservices

Tustin, CA • On-site

$25.48 - $34/hr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 18 days ago

Job description

Description
Looking to join a passionate team dedicated to developing and manufacturing life-saving biopharmaceuticals? Avid Bioservices is a leading clinical and commercial biologics CDMO focused on creating innovative solutions to meet the needs of our clients and improve patient outcomes.
Your Role:
The primary responsibilities of the Downstream - Manufacturing Technical Specialist are to collaborate with the technical MFG Supervisor/Manager to ensure the successful transfer and execution of Downstream processes, and to serve as the main point of contact for QA, MSAT, and Facility for Downstream technical support. This role requires strong leadership skills and deep technical knowledge in scaling downstream processes, as well as an understanding of MFG Downstream equipment, processes, and the setup of Manufacturing Downstream Operations for success.
The MFG Technical Specialist supports the MFG Technical Supervisor/Manager in overseeing the transfer of all new projects and any changes to existing projects from MSAT to manufacturing. They will assist MFG Leads in the progress of technical and on-the-job training for the MFG team; as well as aid in maintaining the equipment list and calibration/PM schedule and will coordinate with Facility and MSAT to ensure successful equipment readiness for all manufacturing processes.
  • Develops and cultivates positive internal Avid group (MSAT, Facility, MFG, QA, Validations, IT, Computerized Systems/Automation, etc.) partnerships.
  • Working with MFG Technical Supervisor/Manager in Overseeing and approving the BPR, Unicorn method, BOM, and buffer and solution planning as the manufacturing stakeholder.
  • Working with MFG Technical Supervisor/Manager to identify and initiate process and procedural changes to improve performance, robustness, productivity, safety, efficiency, and compliance.
  • Communicating with Client, MSAT, and QA on Process Status and collaborating to resolve technical issues on the floor.
  • Maintaining and managing the equipment list and needs for all downstream processes. Collaborating with facility and MSAT to ensure successful and sufficient equipment allocations for all processes.
  • Reviewing Manufacturing Batch Production Records, Technical Reports, Standard Operating Procedures.
  • Leading technical training to Manufacturing Downstream Operators.
  • Supporting MFG Technical Supervisor/Manager in CAPA (Corrective Action Preventive Action) investigations and recommending dispositions for the manufacturing team.
  • Other tasks may be assigned as needed.

Minimum Qualifications:
  • B.S/M.S. in scientific or engineering (chemical or biomedical) discipline.
  • 4+ years of Experience downstream MFG with B.S and 2+ years with M.S.
  • Strong technical experience within relevant manufacturing process technologies and unit operations. Experience of commercial cGMP manufacturing.
  • Technical expertise in Downstream processes such as depth filtration, purification by affinity, ion exchange, and hydrophobic interaction chromatography, viral inactivation and filtration, tangential flow filtration, sterile filtration, and bulk drug substance fills.
  • Hands-on experience with downstream process equipment including, but not limited to AKTA ready column chromatography skids, large-scale filtration skids, Unicorn software.
  • Track record for analyzing and resolving complex manufacturing and production issues using sound scientific principles.
  • The ability to work effectively and lead small matrix and cross-functional teams in a fast-paced environment with changing priorities and a high level of urgency.
  • Highly motivated with the ability to work independently as well as on cross-functional and cross-site teams.
  • Customer service skillset via escorting of person in plant (PIP) or through prior work experience.
  • Strong knowledge of cGMPs or equivalent standards.
  • Sound decision-making skillset to resolve or escalate deviations and/or issues on the production floor.
  • Communicate clearly and professionally both in writing and verbally.
  • Proficient time management/multi-tasking and project oversite skills.
  • Strong leadership and management skillset.

Position Type/Expected Hours of Work:
This role is a full-time position operating Monday through Friday, 5x8 (5 days x 8 hours) schedule from 8am to 5pm PST unless otherwise stated by Supervisor. Must be able to work overtime, weekends, and/or holidays if needed.
Compensation:
We offer competitive compensation packages for this role, including a base salary, performance-based bonuses, and comprehensive benefits such as health, dental, and vision insurance, 401(k) matching, and paid time off.
The compensation range for this role is $25.48 to $34.00 hourly, depending on experience and qualifications. Additionally, we offer opportunities for career growth and development as well as a supportive and inclusive work environment.
Who you are:
  • You have a "bring it on!" team player approach and an unshakable positive attitude, always ready to tackle anything that comes your way.
  • Your written and verbal skills are out of this world, and you communicate with clarity and confidence.
  • You have exceptional multitasking skills and an unparalleled attention to detail that ensure the smooth running of everything.
  • You are a master at building relationships, capable of establishing connections with anyone, be it team members, clients, vendors, or suppliers.

Physical Demands & Work Environment:
In this dynamic role, expect a blend of regular activities like sitting, standing, and walking, with occasional physically engaging tasks such as lifting objects up to 20 pounds. The work environment might expose you to electrical shocks, toxic chemicals, vibrations, or loud noise levels occasionally. However, reasonable accommodations are available to enable individuals with different abilities to perform effectively, ensuring a supportive and adaptable work setting. Your visual acuity, including close, distance, and color vision, will be essential in navigating through the diverse day-to-day demands of this position.

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