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Downstream Engineer information

What is a downstream engineer?

Downstream Engineers are professionals who work in the downstream sector of the oil and gas industry, which involves the refining of crude oil, processing of raw natural gas, and the distribution and marketing of petroleum products. They are responsible for designing, operating, and optimizing processes in refineries and petrochemical plants to ensure efficient and safe production. Downstream Engineers also work on improving product quality, reducing environmental impact, and troubleshooting operational issues. Their roles often require strong knowledge of chemical engineering, process optimization, and safety regulations.

What are some common challenges faced by downstream engineers when optimizing refinery processes?

Downstream Engineers often face the challenge of balancing efficiency, safety, and environmental compliance while optimizing refinery processes. They must troubleshoot complex systems, identify bottlenecks, and implement solutions that maximize yield without compromising product quality or safety standards. Additionally, adapting to evolving regulations and integrating new technologies, such as digital process control systems, requires continuous learning and collaboration with multidisciplinary teams. These challenges make the role dynamic and rewarding for engineers who enjoy problem-solving and innovation.

What are the key skills and qualifications needed to thrive as a downstream engineer, and why are they important?

To thrive as a Downstream Engineer, you need a solid background in chemical or petroleum engineering, process optimization, and industrial safety, usually supported by a relevant engineering degree. Familiarity with process simulation software (like Aspen HYSYS or ChemCAD), industry standards, and certifications such as Professional Engineer (PE) are typically required. Strong analytical thinking, problem-solving, and effective communication skills help you collaborate with multidisciplinary teams and address operational challenges. These skills and qualifications are vital for ensuring safe, efficient, and compliant operation of refining and petrochemical processes.

What are the most commonly searched types of Downstream Engineer jobs in California?

The most popular types of Downstream Engineer jobs in California are:

What are popular job titles related to Downstream Engineer jobs in California?

For Downstream Engineer jobs in California, the most frequently searched job titles are:

What job categories do people searching Downstream Engineer jobs in California look for?

The top searched job categories for Downstream Engineer jobs in California are:

Downstream Engineer jobs near you
Infographic showing various Downstream Engineer job openings in California as of August 2026, with employment types broken down into 87% Full Time, and 13% Contract. Highlights an 92% In-person, 4% Hybrid, and 4% Remote job distribution.

Principal Engineer I/II, MSAT / Viral Vector Downstream

Azalea Therapeutics, Inc.

Berkeley, CA • On-site

$170K - $215K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 19 days ago

Job description

Job Title: Principal Engineer I/II, MSAT / Viral Vector Downstream
Department: External CMC Operations
Reports to: VP of External CMC Operations
Location: Onsite 5 days per week at our Berkeley, CA office
Employment Type: Full-time
FLSA Status: Exempt
Bonus/Equity: Eligible
About Azalea
Azalea Therapeutics is enabling precision genome engineering directly inside the body, with an initial focus on creating cancer immunotherapies in vivo. Azalea is pioneering a new way to turn a person's own T cells into a powerful cancer therapy - directly inside the body. Instead of removing cells and manipulating them in a lab, we use precision genome editing tools to engineer T cells where they already live. At the center of our approach are Enveloped Delivery Vehicles, or EDVs. As highly selective couriers, EDVs are designed to specifically locate T cells within the patient and deliver our genome engineering cargo. Once inside the cell, the anti-cancer agent is inserted into a precise site in the genome, ensuring safe and potent modifications to fortify the T cells against cancers.
Why this matters:
  • We aim to make cell therapy faster and more accessible by avoiding complex manufacturing outside the body.
  • Our platform is designed for precision, so the right cells are safely programmed to effectively fight cancer.
  • This technology has the potential to treat a wide range of cancers with a streamlined, scalable process.

Our goal is simple: develop next-generation delivery technologies to bring genetic engineering and cell therapies to more patients.
How We Work
Azalea is building ambitious science in a fast-moving environment. The people who thrive here are accountable, adaptable, rigorous, humble, and direct. Across roles and functions, we look for team members who demonstrate the following:
  • Outcome Ownership - We own results, close loops, and follow through without needing to be prompted. We take responsibility for moving work forward and making sure important decisions, deliverables, and handoffs do not fall through the cracks.
  • Comfort with Ambiguity - We operate in an early-stage environment where information may be incomplete and priorities may evolve. We clarify quickly, make thoughtful decisions with the information available, and adapt without unnecessary drama.
  • High Standards, Low Ego - We care deeply about the quality of the work and the impact it can have for patients. We raise the bar while staying humble, direct, and open to feedback.
  • Collaboration and Candor - We share context early, communicate clearly, partner across functions, and operate with transparency. We believe strong collaboration requires both trust and direct communication.

The Opportunity
Azalea is seeking a Principal Engineer I/II, Manufacturing Science and Technology (MSAT) - Viral Vector Downstream to serve as the senior technical lead for downstream viral vector technology transfer, and manufacturing readiness. Reporting to the VP of External CMC Operations, the immediate focus for this role will be advancing the EDV and AAV manufacturing capabilities required to move pipeline programs toward first-in-human readiness, including pilot runs, engineering runs, and initiation of GMP manufacturing.
This is a senior individual-contributor role aligned with Azalea's Principal Scientist I/II levels. The Principal Engineer will be accountable for the technical direction of a major manufacturing area, not only the execution of assigned activities. This person will work closely with the internal process development teams to define priorities, connect downstream process decisions to program and company goals, provide technical leadership across external manufacturing partners, mentor other contributors, and influence cross-functional decisions with limited oversight.
The ideal candidate is a hands-on downstream process expert who can move between detailed data analysis and broader CMC strategy. This person should be comfortable leading through influence in a lean, externally networked organization, making clear recommendations with incomplete information, and balancing speed, quality, manufacturability, regulatory expectations, and patient-focused progress.They will be responsible for managing the technology transfer of our EDV and AAV manufacturing processes to our external manufacturing partners for the current and future programs. This is a full-time onsite position at our Headquarters in Berkeley, CA. The incumbent will travel and be onsite at the CDMO during manufacturing.
Key Responsibilities
  • Define and lead the external downstream process strategy for Azalea's viral vector programs, with an immediate focus on EDV and AAV manufacturing for Program 1.
  • In collaboration with the PD team, assist with downstream process development, optimization, scale-up, and manufacturing readiness activities across clarification, filtration, chromatography, ultrafiltration/diafiltration, formulation interfaces, sterile filtration, hold-time strategy, and other relevant unit operations.
  • Establish phase-appropriate process understanding and control strategies, including identification of critical quality attributes, critical process parameters, key material attributes, process risks, and appropriate monitoring approaches.
  • Own downstream technology transfer to contract development and manufacturing organizations (CDMOs), including transfer plans, process descriptions, protocols, batch records, training, readiness assessments, and transfer acceptance criteria.
  • Provide technical leadership for pilot, engineering, and GMP manufacturing runs. Review data in real time, identify trends or emerging risks, troubleshoot complex process issues, and drive clear decisions and follow-up actions.
  • Lead or support investigations of process deviations, manufacturing failures, atypical results, and recurring performance issues. Develop scientifically sound root-cause hypotheses, corrective actions, and risk-reduction plans in partnership with Quality and external manufacturers.
  • Work collaboratively with internal PD teams to establish scale-down models that can be used for, process characterization, comparability, and other studies appropriate to Azalea's development stage and program needs.
  • Partner closely with Analytical Development and Quality Control teams to define in-process controls, sampling plans, analytical needs, acceptance criteria, and the data required to support process decisions and product release.
  • Collaborate with Process Development, Formulation, Quality, Regulatory, Supply Chain, Program Management, Research, and other technical partners to align external manufacturing with integrated CMC and company milestones.
  • Provide technical oversight of external partners, including scope definition, timeline management, technical review, issue escalation, and assessment of partner capabilities and performance.
  • Contribute to CMC regulatory strategy, technical documentation, health-authority briefing materials, IND-enabling content, and responses related to downstream manufacturing and process control.
  • Work with the internal and external process development team to evaluate new technologies, process improvements, and manufacturing approaches that may improve yield, purity, robustness, scalability, cycle time, cost, or long-term platform capability, with a concise objective of decreasing COGs.
  • Model Azalea's operating principles by owning outcomes, raising risks early, communicating recommendations directly, collaborating across functions, and maintaining high standards with low ego.

Qualifications
  • Minimum Qualifications
    • Bachelor's degree in chemical engineering, biochemical engineering, bioengineering, biotechnology, or a related discipline with 12+ years of relevant experience; Master's degree with 10+ years; or PhD with 8+ years. Equivalent combinations of education and experience will be considered.
    • Skilled in downstream processing, MSAT, or manufacturing technical support for viral vectors, gene therapies, vaccines, or complex biologics. Direct viral vector experience is required.
    • Demonstrated success collaborating with the downstream process development teams through scale-up, to support technology transfer, engineering runs, and GMP manufacturing.
    • Strong technical depth in purification and recovery operations such as clarification, depth filtration, chromatography, ultrafiltration/diafiltration, sterile filtration, and process hold strategies.
    • Experience establishing process understanding and control strategies using risk assessments, critical quality attributes, critical process parameters, process trending, and data-driven decision-making.
    • Experience overseeing CDMOs or external manufacturing partners and holding technical teams accountable for quality, timing, documentation, and issue resolution.
    • Working knowledge of GMP expectations, phase-appropriate process validation, change control, deviation investigation, comparability, and relevant ICH and regulatory principles.
    • Strong analytical and troubleshooting capability, including the ability to integrate complex manufacturing and analytical data, distinguish facts from assumptions, and make clear technical recommendations.
    • Ability to communicate technical risks, tradeoffs, and decisions clearly to cross-functional teams, senior leaders, external partners, and regulatory contributors.
  • Preferred Qualifications
    • Experience with upstream operations, such as transient transfection of bioreactors in a GMP environment for viral vectors, primarily Lenti and AAV.
    • Experience with AAV, lentiviral vectors, enveloped viral vectors, engineered delivery vehicles, or related gene-delivery modalities.
    • Has supported both internally developed processes and externally executed manufacturing in an early-stage biotechnology company.
    • History with design of experiments, multivariate analysis, statistical process evaluation, or process modeling.
    • Proven success developing process characterization, comparability, or validation strategies for clinical-stage products.
    • Has contributed to pre-IND or IND documentation, submissions, and health-authority interactions for viral vector or gene therapy programs.
    • Familiarity with upstream-downstream interfaces, formulation, analytical control strategies, raw-material risk, single-use systems, and manufacturing network design.
    • Demonstrated ability to mentor technical contributors and lead major workstreams through influence without relying on formal authority.

What Success Looks Like (first 3-6 months)
  • Develops a strong understanding of Azalea's platform, AZA-2509 program strategy, EDV and AAV manufacturing processes, external manufacturing network, and 2026 company goals.
  • Works collaboratively with our CDMO to complete a practical downstream manufacturing-readiness assessment that identifies the highest-priority technical gaps, process risks, data needs, and decisions required for pilot, engineering, and GMP execution.
  • Establishes an integrated downstream work plan with clear owners, milestones, dependencies, and decision points aligned with AZA-2509 manufacturing timelines.
  • Clarifies the phase-appropriate process control strategy, including key quality attributes, process parameters, in-process controls, sampling needs, and escalation thresholds.
  • Provides credible technical leadership during manufacturing planning and execution, resolving priority issues quickly while maintaining scientific rigor and documentation quality.
  • Contributes clear downstream manufacturing content to CMC planning, regulatory materials, and integrated program decisions.
  • Becomes a trusted technical authority who improves decision quality, raises standards, and helps Azalea move complex manufacturing work forward with limited oversight.
  • Ability to work in a hybrid environment with regular engagement with Bay Area-based colleagues, laboratories, and external partners.
  • Ability to travel as needed to CDMOs, testing laboratories, manufacturing sites, technical meetings, and company business locations.
  • Ability to work in laboratory or manufacturing environments as needed and comply with applicable safety, gowning, and personal protective equipment requirements.
  • This role includes substantial computer-based technical work, data review, document preparation, and virtual and in-person collaboration.

Working Conditions / Physical Requirements (as applicable)
  • Travel 40%, expected to be PIP for all GMP operations
  • Ability to lift 50lbs and stand for at least 6-8 hours

Compensation and Benefits
  • The expected salary range for this role based on the primary location for this position in California is $170,000 - $215,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law. Salary will be commensurate with experience, qualifications, training and market.
  • This role is eligible for annual performance bonuses, equity grants, and a comprehensive benefits package that includes medical, dental, vision, retirement plan with company match, and paid time off.

Azalea's Commitments
Equal Employment Opportunity (EEO): Azalea is an equal opportunity employer. We consider qualified applicants without regard to race, color, religion, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, military or veteran status, or any other characteristic protected by applicable law.
Reasonable Accommodation: We will provide reasonable accommodation to qualified individuals with disabilities and to individuals with sincerely held religious beliefs, consistent with applicable

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