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Upstream Manufacturing Jobs (NOW HIRING)

Kinetic Personnel Group

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Manufacturing Associate Biopharma

Tustin, CA · On-site

$20 - $21/hr

Upstream Manufacturing Associate Position Summary We are seeking a motivated Upstream Manufacturing Associate to join our biopharmaceutical manufacturing team. This entry-level position supports the ...

Kinetic Personnel Group

Be Seen First

Manufacturing Associate Biopharma

Tustin, CA · On-site

$20 - $21/hr

Upstream Manufacturing Associate Position Summary We are seeking a motivated Upstream Manufacturing Associate to join our biopharmaceutical manufacturing team. This entry-level position supports the ...

Stellent IT LLC

CQV Lead, Upstream

Holly Springs, NC · On-site

$88K - $116K/yr

... Manufacturing This leadership role will be responsible for ensuring end-to-end CQV delivery for upstream systems including single-use bioreactors, large-scale stainless steel bioreactors, and ...

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How much do upstream manufacturing jobs pay per hour?

As of Jul 21, 2026, the average hourly pay for upstream manufacturing in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What is upstream manufacturing?

Upstream manufacturing refers to the initial stages of the production process in industries like biotechnology and pharmaceuticals, where raw materials such as cells, bacteria, or yeast are cultivated to produce a desired product. This stage typically includes activities like cell culture, fermentation, and media preparation. The goal is to optimize the growth and productivity of the biological system to ensure efficient production before moving to downstream processing, which involves purification and formulation of the final product.

What are some common challenges faced in upstream manufacturing, and how are they typically addressed by teams?

In upstream manufacturing, one of the main challenges is maintaining consistent cell culture conditions to optimize yield and product quality. Teams often face issues such as contamination, variability in raw materials, and equipment malfunctions. To address these challenges, upstream teams implement rigorous standard operating procedures (SOPs), utilize real-time monitoring systems, and collaborate closely with quality assurance and process engineering teams. Regular team meetings and cross-functional communication are key to quickly identifying and solving problems, ensuring smooth production runs.

What are the key skills and qualifications needed to thrive in Upstream Manufacturing, and why are they important?

To thrive in Upstream Manufacturing, you need a solid understanding of bioprocessing, cell culture techniques, and process engineering, often supported by a degree in biotechnology, chemical engineering, or a related field. Familiarity with bioreactors, process control systems, and cGMP regulations is typically required, along with certifications like Six Sigma or Lean Manufacturing being advantageous. Strong analytical thinking, attention to detail, and effective teamwork are essential soft skills for excelling in this field. These capabilities ensure efficient production, product quality, and compliance with industry standards in a highly regulated environment.

What is the difference between Upstream Manufacturing vs Downstream Manufacturing?

AspectUpstream ManufacturingDownstream Manufacturing
FocusRaw material extraction and initial processingFinal product assembly and packaging
Work EnvironmentFactories, extraction sitesAssembly lines, packaging facilities
CredentialsTechnical certifications, safety trainingQuality control, packaging certifications
Industry UsageOil & gas, chemicals, miningPharmaceuticals, food production, consumer goods

Upstream Manufacturing involves the extraction and initial processing of raw materials, while Downstream Manufacturing focuses on transforming these materials into finished products. Both roles are essential in the supply chain but differ in their processes, environments, and required skills.

More about Upstream Manufacturing jobs
What are the most commonly searched types of Upstream Manufacturing jobs? The most popular types of Upstream Manufacturing jobs are:
What states have the most Upstream Manufacturing jobs? States with the most job openings for Upstream Manufacturing jobs include:
What job categories do people searching Upstream Manufacturing jobs look for? The top searched job categories for Upstream Manufacturing jobs are:
Upstream Manufacturing jobs near you
Infographic showing various Upstream Manufacturing job openings in the United States as of July 2026, with employment types broken down into 90% Full Time, 4% Part Time, 1% Temporary, 3% Contract, and 2% Nights. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.
Upstream Manufacturing Associate

Upstream Manufacturing Associate

Kinetic Personnel Group

Tustin, CA • On-site

Other

Posted 6 days ago

Job description

Upstream Manufacturing Associate Position Summary We are seeking a motivated Upstream Manufacturing Associate to join our biopharmaceutical manufacturing team. This entry-level position supports the production of biologic drug substances through upstream manufacturing processes in a cGMP-regulated environment. The ideal candidate is a recent graduate with a strong scientific background who is eager to begin a career in biopharmaceutical manufacturing. Key Responsibilities Perform upstream manufacturing activities including media and buffer preparation, cell culture support, and bioreactor operations. Execute manufacturing processes according to batch records, standard operating procedures (SOPs), and cGMP requirements. Operate, monitor, clean, and maintain manufacturing equipment and process systems. Accurately complete batch records and manufacturing documentation in accordance with Good Documentation Practices (GDP). Monitor critical process parameters and report any deviations or equipment issues. Assist with equipment setup, sanitization, and routine maintenance activities. Maintain a clean and organized manufacturing environment while following safety and contamination control procedures. Collaborate with Manufacturing, Quality Assurance, Quality Control, and Engineering teams to support production goals. Participate in training programs and continuously develop technical knowledge of upstream bioprocessing. Minimum Qualifications Bachelor's degree required in Biology, Chemistry, Biochemistry, or a closely related Life Science discipline. No prior industry experience required. Recent graduates are encouraged to apply. Basic understanding of cell biology, microbiology, biochemistry, or laboratory techniques gained through coursework or academic laboratory experience. Strong attention to detail and ability to follow written procedures. Excellent communication and teamwork skills. Ability to work in a fast-paced, regulated manufacturing environment. Basic computer proficiency, including Microsoft Office. Preferred Qualifications Academic laboratory experience with cell culture, microbiology, or biochemistry. Knowledge of cGMP, aseptic techniques, or biopharmaceutical manufacturing principles through coursework or internships. Experience using laboratory equipment such as balances, pH meters, pipettes, or analytical instruments. Physical Requirements Ability to stand for extended periods during manufacturing operations. Ability to lift up to 35 pounds. Ability to wear required personal protective equipment (PPE), including cleanroom gowning. Ability to work flexible schedules, including weekends or holidays, as production needs require. KPG123

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