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Day Shift Upstream Manufacturing Associate information

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How much do day shift upstream manufacturing associate jobs pay per hour?

As of Jun 29, 2026, the average hourly pay for day shift upstream manufacturing associate in the United States is $20.84, according to ZipRecruiter salary data. Most workers in this role earn between $16.35 and $23.32 per hour, depending on experience, location, and employer.

What is a Day Shift Upstream Manufacturing Associate?

A Day Shift Upstream Manufacturing Associate is responsible for preparing and operating equipment to support the initial stages of biopharmaceutical production, typically involving cell culture, fermentation, and media preparation. Working during the day shift, they monitor processes, maintain sterile environments, and ensure production runs smoothly and efficiently. Their work is crucial in ensuring quality and consistency in the early phases of manufacturing biological products such as vaccines or therapeutic proteins.

What is the difference between Day Shift Upstream Manufacturing Associate vs Night Shift Upstream Manufacturing Associate?

AspectDay Shift Upstream Manufacturing AssociateNight Shift Upstream Manufacturing Associate
Work HoursTypically 8 AM - 4 PMTypically 8 PM - 4 AM
Work EnvironmentManufacturing floor during daytime operationsManufacturing floor during nighttime operations
Required SkillsSimilar technical skills, safety protocols, and certificationsSame technical skills, safety protocols, and certifications
Employer UsageCommonly used in biopharma and biotech manufacturingSame industry usage, different shift timing

The main difference between a Day Shift Upstream Manufacturing Associate and a Night Shift Upstream Manufacturing Associate lies in their working hours. Both roles require similar skills, certifications, and work environments, but they operate during different shifts. Employers in biopharma and biotech industries often employ both to ensure continuous production, with shift timing being the primary distinction.

What are the typical collaboration points between a Day Shift Upstream Manufacturing Associate and other teams in a biomanufacturing facility?

Day Shift Upstream Manufacturing Associates frequently collaborate with downstream processing teams, quality control, and process engineering staff. Daily responsibilities often involve communicating batch progress, troubleshooting issues, and ensuring compliance with safety and GMP standards. Clear documentation and timely reporting to supervisors and quality teams are crucial for maintaining production flow. This cross-functional teamwork ensures efficient handoffs and rapid response to any process deviations, making collaboration a key part of the role.

What are the key skills and qualifications needed to thrive as a Day Shift Upstream Manufacturing Associate, and why are they important?

To excel as a Day Shift Upstream Manufacturing Associate, you typically need a background in biotechnology or life sciences, experience with aseptic techniques, and an understanding of Good Manufacturing Practices (GMP). Familiarity with bioreactors, cell culture systems, and process control software is commonly required, along with relevant safety or GMP certifications. Attention to detail, teamwork, and strong problem-solving abilities are valuable soft skills in this role. These competencies ensure the efficient and compliant production of high-quality biopharmaceuticals in a regulated manufacturing environment.
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Day Shift Upstream Manufacturing Associate jobs near you

Senior Manufacturing Associate (Senior Biotechnologist), Day Shift - Large Scale Allogeneic

Lonza

Portsmouth, NH • On-site

Full-time

Medical, Dental, Vision, PTO

Posted 7 days ago

Key responsibilities

  • Lead upstream manufacturing operations by managing single-use bioreactor systems, cell growth, culture maintenance, and product harvest activities.

  • Provide hands-on operational support during initial engineering runs, training runs, and technical transfer water runs for facility launch.

  • Author, review, and execute cGMP documentation with a focus on generating, troubleshooting, and optimizing Electronic Batch Records, Standard Operating Procedures, and Work Instructions.

Lonza rating

8.2

Company rating: 8.2 out of 10

Based on 41 frontline employees who took The Breakroom Quiz

27th of 73 rated pharmaceutical

Job description

Senior Manufacturing Associate (Senior Biotechnologist) - Large Scale Allogeneic Cell Therapy
Location: Portsmouth, NH, USA.
Schedule: Day Shift, 7:00 AM - 7:00 PM, Rotational 2-2-3 Pattern. Weekend shifts include additional shift differential pay.
Operational Timeline Note: This role supports our brand-new, state-of-the-art Large Scale Allogeneic manufacturing facility. The team is currently gearing up to launch initial facility water runs in July, with routine clinical and commercial production ramping up shortly thereafter.
We are seeking a highly skilled technical leader to join our team in Portsmouth, NH, as a Senior Manufacturing Associate (Senior Biotechnologist). This advanced, floor-based role is responsible for acting as a shop-floor Subject Matter Expert (SME) and leadership anchor during the critical start-up and scaling phases of our brand-new Large Scale Allogeneic asset. Operating under general supervision, you will lead complex, automated unit operations, spearhead operational readiness activities, and manage technical workflows across distinct cleanroom zones. This is an upstream-focused manufacturing role utilizing single-use bioreactor technologies.
What will you get?
  • An agile career and dynamic working culture
  • An inclusive and ethical workplace
  • Brand-New Facility Launch: Play a vital role in the history of the site by driving the very first water runs and production campaigns of a brand-new, large-scale asset.
  • Hybrid Cleanroom Exposure: Gain an optimal operational balance, executing high-stakes aseptic setups in Grade B spaces before transitioning to long-term batch monitoring in Grade C environments.
  • Floor Leadership Path: Serve as a designated floor lead, mentoring junior associates, managing batch progression, and acting as a primary fill-in for the shift supervisor when necessary.
  • Compensation programs that recognize high performance
  • Medical, dental and vision insurance, as well as PTO and more
  • Our full list of global benefits can be found here: https://www.lonza.com/careers/benefits.

What you'll do:
  • Upstream Process Lead: Assume the shop-floor lead role during core upstream manufacturing operations, specifically managing single-use bioreactor systems, cell growth, culture maintenance, and product harvest activities.
  • Hybrid Gowning Execution: Comfortably balance processing environments by dedicating approximately 25% of your time to Grade B gowning, executing critical, high-stakes aseptic processing techniques to start the campaign, while spending the remaining 75% of operations in a Grade C cleanroom setting.
  • Facility Launch Support: Provide hands-on operational support during the facility's initial engineering runs, training runs, and technical transfer water runs scheduled to kick off this July.
  • Documentation & EBR Optimization: Author, review, and execute critical cGMP documentation, with a strong focus on generating, troubleshooting, and optimizing Electronic Batch Records (EBR), Standard Operating Procedures (SOPs), and Work Instructions (WIs).
  • Staff Training & Mentorship: Arrange, coordinate, and deliver effective hands-on training to manufacturing staff regarding new large-scale automated equipment, single-use single systems, and facility quality structures.
  • Quality & Deviation Ownership: Maintain absolute adherence to cGMP and Data Integrity policies, leading minor floor investigations, identifying process bottlenecks, and initiating change controls or CAPAs.
  • Cross-Functional Collaboration: Partner with the shift supervisor, customer SMEs, and Manufacturing Project Specialists to introduce operational improvements and track production milestones effectively.

What we're looking for:
  • Experience: 5-10 years of advanced experience within a cGMP biological or cell therapy manufacturing environment is required. Prior specialized experience in upstream processing (bioreactor inoculation, harvest, single-use systems) is a highly desired plus but not explicitly required.
  • Technical Mastery: Strong working knowledge of cleanroom classifications, aseptic processing techniques, and electronic quality documentation platforms (such as TrackWise).
  • Leadership Traits: Proven ability to direct day-to-day work tasks on the floor, troubleshoot technical processing errors under tight timelines, and maintain high standards of accountability within a matrixed team.
  • Education: High School Diploma or equivalent is required; an Associate's or Bachelor's Degree in a science or engineering discipline is preferred.
  • Physical Requirements: Ability to comfortably stand for extended periods, undergo continuous sterile gowning protocols (Grade B and Grade C), perform precise fine-motor manipulations, and occasionally lift up to 50 lbs.

About Lonza
At Lonza, our people are our greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone's ideas, big or small, have the potential to improve millions of lives, and that's the kind of work we want you to be part of.
Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we offer equal employment opportunities to all qualified applicants regardless of race, religion, color, national origin, sex, sexual orientation, gender identity, age, disability, veteran status, or any other characteristic protected by law. If you're ready to help turn our customers' breakthrough ideas into viable therapies, we look forward to welcoming you on board.
Ready to shape the future of life sciences? Apply now.

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