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Manufacturing Associate Level 1 (cur_1_128716@curatelyai.net)

Portsmouth, NH · On-site

$26 - $27/hr

This is an UpStream MFG role, involving sampling, media prep, and Innoculum. Candidates must be able to gown, lift up to 25 pounds infrequently and stand for long periods of time About ASK: ASK ...

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How much do upstream manufacturing jobs pay per hour?

As of Aug 10, 2026, the average hourly pay for upstream manufacturing in the United States is $24.95, according to ZipRecruiter salary data. Most workers in this role earn between $20.19 and $28.85 per hour, depending on experience, location, and employer.

What is upstream manufacturing?

Upstream manufacturing refers to the initial stages of the production process in industries like biotechnology and pharmaceuticals, where raw materials such as cells, bacteria, or yeast are cultivated to produce a desired product. This stage typically includes activities like cell culture, fermentation, and media preparation. The goal is to optimize the growth and productivity of the biological system to ensure efficient production before moving to downstream processing, which involves purification and formulation of the final product.

What are some common challenges faced in upstream manufacturing, and how are they typically addressed by teams?

In upstream manufacturing, one of the main challenges is maintaining consistent cell culture conditions to optimize yield and product quality. Teams often face issues such as contamination, variability in raw materials, and equipment malfunctions. To address these challenges, upstream teams implement rigorous standard operating procedures (SOPs), utilize real-time monitoring systems, and collaborate closely with quality assurance and process engineering teams. Regular team meetings and cross-functional communication are key to quickly identifying and solving problems, ensuring smooth production runs.

What are the key skills and qualifications needed to thrive in upstream manufacturing?

To thrive in Upstream Manufacturing, you need a solid understanding of bioprocessing, cell culture techniques, and process engineering, often supported by a degree in biotechnology, chemical engineering, or a related field. Familiarity with bioreactors, process control systems, and cGMP regulations is typically required, along with certifications like Six Sigma or Lean Manufacturing being advantageous. Strong analytical thinking, attention to detail, and effective teamwork are essential soft skills for excelling in this field. These capabilities ensure efficient production, product quality, and compliance with industry standards in a highly regulated environment.

What is the difference between Upstream Manufacturing vs Downstream Manufacturing?

AspectUpstream ManufacturingDownstream Manufacturing
FocusRaw material extraction and initial processingFinal product assembly and packaging
Work EnvironmentFactories, extraction sitesAssembly lines, packaging facilities
CredentialsTechnical certifications, safety trainingQuality control, packaging certifications
Industry UsageOil & gas, chemicals, miningPharmaceuticals, food production, consumer goods

Upstream Manufacturing involves the extraction and initial processing of raw materials, while Downstream Manufacturing focuses on transforming these materials into finished products. Both roles are essential in the supply chain but differ in their processes, environments, and required skills.

More about Upstream Manufacturing jobs
What are the most commonly searched types of Upstream Manufacturing jobs? The most popular types of Upstream Manufacturing jobs are:
What states have the most Upstream Manufacturing jobs? States with the most job openings for Upstream Manufacturing jobs include:
What job categories do people searching Upstream Manufacturing jobs look for? The top searched job categories for Upstream Manufacturing jobs are:
Upstream Manufacturing jobs near you
Infographic showing various Upstream Manufacturing job openings in the United States as of August 2026, with employment types broken down into 89% Full Time, 4% Part Time, 4% Contract, and 3% Nights. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $51,890 per year, or $24.9 per hour.

Biopharm Manufacturing Associate (Entry Level)

Alphanumeric

King Of Prussia, PA • On-site

$22 - $23/hr

Contractor

Posted 20 days ago

Job description

Biopharm Manufacturing Associate (Entry Level)
King of Prussia, PA (Upper Merion)
Alphanumeric is hiring a Biopharm Manufacturing Associate to join our client of over 20 years, a global biopharmaceutical leader dedicated to developing life-changing medicines and improving patient lives.
Pay Rate: $22.00-$23.00/hour
Launch Your Career in Biopharmaceutical Manufacturing
Are you a recent science graduate looking to break into the pharmaceutical industry? This is an excellent opportunity to gain hands-on experience in a GMP-regulated manufacturing environment while working alongside experienced professionals supporting the production of innovative therapies.
No prior pharmaceutical manufacturing experience is required-just a strong scientific foundation, attention to detail, and a willingness to learn.
What You'll Do
As a Biopharm Manufacturing Associate, you'll support daily manufacturing operations while ensuring products are produced safely, accurately, and in compliance with GMP regulations.
Responsibilities include:
  • Execute daily manufacturing activities by following Standard Operating Procedures (SOPs) and batch records.
  • Accurately document manufacturing activities in accordance with GMP requirements.
  • Dispense both small and large quantities of raw materials.
  • Perform Cleaning-in-Place (CIP) and Sterilization-in-Place (SIP) of manufacturing equipment and product tanks.
  • Assist with troubleshooting equipment and manufacturing processes.
  • Author, revise, and support SOPs, deviations, and change controls.
  • Operate within a highly regulated GMP manufacturing environment while maintaining quality and compliance standards.
  • Safely handle hazardous materials using established safety procedures.
  • Support continuous improvement initiatives and collaborate across cross-functional teams.
  • Perform additional manufacturing duties as assigned.

Job Requirements
What We're Looking For
Required Qualifications
  • Bachelor's degree in Biology, Chemistry, Chemical Engineering, or another scientific or engineering discipline
  • Familiarity with Good Manufacturing Practices (GMP)
  • Strong written communication and documentation skills
  • Computer proficiency
  • Ability to follow detailed written procedures
  • Strong problem-solving and troubleshooting abilities
  • Ability to work effectively in a collaborative, fast-paced environment
Preferred Qualifications
  • 1+ year of cGMP or pharmaceutical manufacturing experience
  • Knowledge of GMP regulations and documentation practices
  • Experience with upstream manufacturing processes, including media preparation and bioprocess unit operations
  • Familiarity with analytical equipment such as:
    • Vi-Cell
    • NOVA Analyzer
    • Centrifuges
    • Tubing Welders
  • Exposure to PLC, DCS, or HMI systems

Work Environment & Additional Information
  • 100% onsite position based in King of Prussia (Upper Merion), PA
  • Initial 12-month contract with the potential to extend up to 18 months based on business needs and performance
  • This is an Upstream Manufacturing role supporting biopharmaceutical production
  • Candidates must be able to wear a Powered Air-Purifying Respirator (PAPR) as required for the position
  • Following hire, candidates will complete a medical clearance/respirator screening in accordance with OSHA requirements before using a PAPR (Non-SCBA)

Why Join Us?
  • Entry point into the pharmaceutical and biotechnology industry
  • Hands-on GMP manufacturing experience
  • Work with an industry-leading global biopharmaceutical company
  • Collaborative, team-oriented environment
  • Opportunity to develop valuable technical and manufacturing skills
  • Potential for long-term career growth within biopharmaceutical manufacturing

Excellent opportunity to gain hands-on upstream biopharmaceutical manufacturing experience with a global pharmaceutical leader.
If you're passionate about science and ready to launch your career in pharmaceutical manufacturing, we'd love to hear from you!

Apply