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Protein Engineering Jobs (NOW HIRING)

Merck & Co.

$100K - $136K/yr

Our company Discovery Biologics Disruptive Technologies is seeking an exceptional AI/ML protein engineer to drive the application of structure-based computational protein design and optimization ...

MSD

Sr. Scientist, Generative Protein Design

Cambridge, MA

$100K - $136K/yr

Our company Discovery Biologics Disruptive Technologies is seeking an exceptional AI/ML protein engineer to drive the application of structure-based computational protein design and optimization ...

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Protein Engineering information

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$32.5K

$63K

$95.5K

How much do protein engineering jobs pay per year?

As of Aug 10, 2026, the average yearly pay for protein engineering in the United States is $62,977.00, according to ZipRecruiter salary data. Most workers in this role earn between $47,000.00 and $72,000.00 per year, depending on experience, location, and employer.

What is protein engineering?

A Protein Engineering job involves designing, modifying, and optimizing proteins for specific applications in medicine, biotechnology, and industry. Scientists in this field use computational modeling, directed evolution, and genetic engineering to enhance protein functions. Roles may include developing enzymes for drug production, improving therapeutic proteins, or creating biomaterials. This work often requires expertise in molecular biology, biochemistry, and structural biology.

What are the key skills and qualifications needed to thrive in protein engineering, and why are they important?

To thrive in Protein Engineering, you need a solid background in biochemistry, molecular biology, and genetic engineering, typically supported by a relevant advanced degree. Experience with laboratory techniques such as PCR, site-directed mutagenesis, protein expression/purification, and analytical tools like mass spectrometry or chromatography is essential. Strong problem-solving abilities, attention to detail, and effective teamwork and communication skills help you stand out in this role. These competencies are crucial for designing novel proteins, collaborating in multidisciplinary teams, and ensuring successful project outcomes in biotech or pharmaceutical environments.

What are the typical daily responsibilities of someone working in protein engineering?

A typical day in Protein Engineering involves designing and conducting experiments to modify protein sequences, expressing and purifying proteins, and analyzing their structure or function using techniques like chromatography and spectroscopy. You will often document your results, troubleshoot unexpected findings, and present data to colleagues or project teams. Collaboration with scientists in molecular biology, bioinformatics, and structural biology is common to ensure robust experimental design and data interpretation. The role may also include literature reviews to stay updated with the latest research and participating in team meetings to plan next steps or project timelines.

How much do protein engineers make?

Protein engineers typically earn a median salary ranging from $70,000 to $120,000 annually, depending on experience, education, and location. Advanced skills in molecular biology, bioinformatics, and laboratory techniques can lead to higher compensation, especially in biotech or pharmaceutical industries.

What do protein engineers do?

Protein engineers design and modify proteins to improve their functions or create new ones, often using techniques like directed evolution and computational modeling. They work in research labs, utilizing tools such as gene editing and structural analysis to develop applications in medicine, agriculture, and industry.
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Protein Engineering jobs near you
Infographic showing various Protein Engineering job openings in the United States as of August 2026, with employment types broken down into 90% Full Time, 5% Part Time, 4% Contract, and 1% Nights. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $62,977 per year, or $30.3 per hour.

Scientist-Principal Scientist, Protein Design & Structure

Superluminal Medicines, Inc.

Boston, MA

Full-time

Re-posted 10 days ago

Job description

Position Summary

We are seeking a highly innovative and experienced Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering and production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs. This role involves hands-on laboratory work and scientific leadership. 

Key Responsibilities

  • Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression.
  • Expression & Purification: Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
  • Cross-Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization.
  • Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies.
  • Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings.

Required Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience; or a master's or bachelor's degree in a related field with commensurate industry experience. 
  • Deep knowledge of GPCR biology and membrane protein structure-function relationships.
  • Proven expertise in molecular biology (cloning, construct design, mutagenesis).
  • Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC).
  • Familiarity with protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).
  • Excellent communication, interpersonal, and leadership skills.

Preferred Qualifications

  • Experience with structural biology methods (data collection and processing for Cryo-EM).
  • Experience in laboratory automation in protein sciences & purification.
  • Background in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction).

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