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Director Protein Engineering Jobs (NOW HIRING)

Systimmune

Director, Protein Engineering

Redmond, WA · On-site

$180K - $240K/yr

SystImmune is seeking a Director of Protein Engineering to lead the FUSE team. This is a hands-on scientific leadership role that combines team management, platform ownership, and program-level ...

Alloy Therapeutics

Director, Protein Science

Waltham, MA · On-site

$170K - $200K/yr

About the Role at Alloy Therapeutics As Director of Protein Science, you will lead a team ... Integrate protein engineering and cutting-edge efforts efficiently into product offerings and ...

New

Alloy Therapeutics

Director, Protein Science

Waltham, MA · On-site

$150 - $200/hr

About the Role at Alloy Therapeutics As Director of Protein Science, you will lead a team ... Integrate protein engineering and cutting-edge efforts efficiently into product offerings and ...

New

Alloy Therapeutics

Director, Protein Science

Waltham, MA · On-site

$170K - $200K/yr

About the Role at Alloy Therapeutics As Director of Protein Science, you will lead a team ... Integrate protein engineering and cutting-edge efforts efficiently into product offerings and ...

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Director Protein Engineering information

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$73K

$194.7K

$254K

How much do director protein engineering jobs pay per year?

As of Sep 7, 2026, the average yearly pay for director protein engineering in the United States is $194,709.00, according to ZipRecruiter salary data. Most workers in this role earn between $141,500.00 and $253,000.00 per year, depending on experience, location, and employer.

What does a director protein engineering do?

A Director of Protein Engineering leads teams in designing, optimizing, and developing proteins for various applications, such as therapeutics, biotechnology, or industrial enzymes. They oversee research strategies, manage cross-functional collaborations, and ensure project goals align with company objectives. This role requires expertise in molecular biology, structural biology, and protein design, along with strong leadership and project management skills.

What are the key skills and qualifications needed to thrive in the director protein engineering position?

A Director Protein Engineering typically requires a PhD in biochemistry, molecular biology, or related fields, along with extensive experience in protein engineering, assay development, and team leadership. Familiarity with industry-standard tools like molecular modeling software, high-throughput screening systems, and relevant regulatory compliance certifications is important. Exceptional project management, communication, and strategic decision-making skills help in guiding cross-functional teams and driving innovation. These competencies ensure effective oversight of research programs, facilitate collaboration, and enable advanced problem-solving to achieve organizational goals.

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Director Protein Engineering jobs near you
Infographic showing various Director Protein Engineering job openings in the United States as of August 2026, with employment types broken down into 92% Full Time, 4% Part Time, 3% Contract, and 1% Nights. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $194,709 per year, or $93.6 per hour.

Senior Scientific Director, Protein Engineering

Scorpion Therapeutics

San Diego, CA • On-site

$250/hr

Other

Posted 8 days ago

Job description

About The Role

Senior Scientific Director, Protein Engineering provides scientific and strategic leadership for Neurocrine’s protein engineering and biologics discovery capabilities. Leads a team of protein engineers and expands technical expertise/platforms to enable next-generation biotherapeutics.

Your ContributionsScientific Leadership
  • Lead and provide strategic direction for the Protein Engineering function; set scientific priorities for the biologics portfolio
  • Guide programs from target assessment through lead generation, optimization, candidate selection, and transition into development
  • Drive innovation in antibody and protein engineering technologies
  • Evaluate and implement emerging technologies, platforms, and computational approaches
Organizational Leadership
  • Lead, mentor, and develop protein engineering talent; recruit additional scientific talent
  • Foster a collaborative, innovative, inclusive scientific culture
  • Build capabilities via investment in new technologies, workflows, and expertise
  • Establish/maintain collaborations with CROs, academics, and technology providers
Drug Discovery & Cross-Functional Collaboration
  • Partner cross-functionally to advance biologics programs through discovery and IND-enabling studies
  • Lead candidate selection, developability assessment, and optimization strategies
  • Provide data-driven recommendations for governance and portfolio decisions
  • Ensure protein engineering work aligns with timelines, quality standards, and objectives
RequirementsRequired
  • PhD (10+ years) OR Master’s (20+ years) OR Bachelor’s (22+ years) in relevant discipline
  • Demonstrated scientific leadership advancing antibody/protein therapeutics from discovery through IND-enabling development
  • Extensive expertise in protein/antibody engineering and structure-function relationships
  • Expertise in protein conjugation, multispecifics, ADCs, or other next-gen biologics
  • Experience leading high-performing scientific teams and building protein engineering capabilities
  • Deep knowledge of biologics discovery workflows (molecular design, lead optimization, developability, candidate selection)
  • Strong construct design, recombinant expression (mammalian/microbial), purification, biochemical/biophysical characterization
  • Knowledge of antibody discovery technologies (e.g., display platforms, affinity maturation, engineered scaffolds)
  • Experience managing CRO/external collaborations; strong publication/patent record
  • Excellent scientific communication; ability to translate strategy into executable plans
Preferred
  • Experience developing therapeutic antibodies/biologics in neuroscience, endocrinology, immunology, or inflammation
  • Computational protein design, ML-enabled engineering, or AI-assisted design
  • High-throughput screening, protein display, developability assessment
  • Familiarity with LC-MS characterization
  • Knowledge of regulatory expectations for IND submission
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